Diagnostic value of serum carbohydrate antigen 19-9 in pancreatic cancer: a meta-analysis

Abstract Background This study aimed to investigate the effect of combination of plasma miR-181b, miR-196a and miR-210 on early diagnosis of pancreatic cancer (PC).Methods In our study, the plasma was isolated from patients with PC and healthy individuals, respectively. The expressions of miR-181b, miR-196a and miR-210 were detected by qRT-PCR. Moreover, the level of carbohydrate antigen 199 (CA199) was measured by electrochemiluminescence (ECL) assay. Furthermore, the area under the receiver operating characteristic (ROC) curve (AUC) was used to analyze the diagnostic efficacy of miR-181b, miR-196a, miR-210 and CA199, as well as the combination of thses miRNAs in early PC patients and healthy individuals.Results The expressions of miR-181b, miR-196a and miR-210 were significantly upregulated in PC patients. In addition, the level of CA199 was also significantly upregulated in the plasma of PC patients. The expressions of miR-181b, miR-196a and miR-210 were closely associated with lymph nodes metastasis, clinical stage and vascular invasion, but had no correlation with the patient's age, gender and tumor size. Moreover, miR-181b, miR-196a and miR-210 have lower AUC than CA199 in PC patients. The combinations miR-181b + miR-196a, miR-181b + miR-210, miR-196a + miR-210 also have lower AUC than CA199 in PC patients. It is worth noting that the combinations miR-181b + miR-196a + miR-210 have higher AUC than CA199 in PC.Conclusions Our study demonstrated that the combination of plasma miR-181b, miR-196a and miR-210 had good value for PC early diagnosis.

Download Full-text

The combination of the serum carbohydrate antigen 19-9 and carcinoembryonic antigen is a simple and accurate predictor of mortality in pancreatic cancer patients

Surgery Today ◽

10.1007/s00595-013-0752-9 ◽

2013 ◽

Vol 44 (9) ◽

pp. 1692-1701 ◽

Cited By ~ 29

Author(s):

Mitsuro Kanda ◽

Tsutomu Fujii ◽

Hideki Takami ◽

Masaya Suenaga ◽

Yoshikuni Inokawa ◽

...

Keyword(s):

Pancreatic Cancer ◽

Carcinoembryonic Antigen ◽

Cancer Patients ◽

Carbohydrate Antigen ◽

Accurate Predictor ◽

Serum Carbohydrate Antigen

Download Full-text

Prognostic value of pretreatment serum carbohydrate antigen 19-9 level in patients with colorectal cancer: A meta-analysis

PLoS ONE ◽

10.1371/journal.pone.0188139 ◽

2017 ◽

Vol 12 (11) ◽

pp. e0188139 ◽

Cited By ~ 3

Author(s):

Zhan Yu ◽

Zhen Chen ◽

Jian Wu ◽

Zhong Li ◽

Yugang Wu

Keyword(s):

Colorectal Cancer ◽

Prognostic Value ◽

Meta Analysis ◽

Carbohydrate Antigen ◽

Serum Carbohydrate Antigen ◽

Pretreatment Serum

Download Full-text

Early decrement of serum carbohydrate antigen 19-9 predicts favorable outcome in advanced pancreatic cancer

Pancreatology ◽

10.1016/j.pan.2016.06.199 ◽

2016 ◽

Vol 16 (4) ◽

pp. S54

Author(s):

Jikon Ryu ◽

Yong-Tae Kim

Keyword(s):

Pancreatic Cancer ◽

Advanced Pancreatic Cancer ◽

Carbohydrate Antigen ◽

Favorable Outcome ◽

Serum Carbohydrate Antigen

Download Full-text

Meta-analysis of the diagnostic performance of circulating microRNAs for pancreatic cancer

10.21203/rs.2.18339/v3 ◽

2020 ◽

Author(s):

Cheng Peng ◽

Zhiqiang Li ◽

Lihua Huang ◽

Wenzhe Gao ◽

Jiale Wang ◽

...

Keyword(s):

Pancreatic Cancer ◽

Diagnostic Accuracy ◽

Diagnostic Performance ◽

Early Stage ◽

Meta Analysis ◽

Carbohydrate Antigen ◽

Cochrane Library ◽

Circulating Mirnas ◽

China National Knowledge Infrastructure ◽

Circulating Micrornas

Abstract Background: Pancreatic cancer (PC) is characterized by high malignancy and a poor prognosis. The detection of circulating microRNAs (miRNAs) is a liquid biopsy diagnostic approaches. Numerous studies have suggested that some differentially expressed miRNAs may be promising diagnostic markers for PC, but the results have varied among studies. The present study was performed to summarize the diagnostic accuracy of circulating miRNAs, carbohydrate antigen 19-9 (CA19-9), and the combination of miRNAs and CA19-9.Methods: A literature search of online databases including PubMed, EMBASE, Cochrane Library, China National Knowledge Infrastructure (CNKI) and WanFang was conducted. Relative data were extracted from eligible included studies, and a meta-analysis was performed.Results: A total of 46 studies involving 4,326 PC patients and 4,277 non-PC controls were included. The pooled sensitivity (SEN), specificity (SPE) and AUC of the circulating miRNAs for differentiating PC patients from non-PC controls were 0.79 (0.77-0.81), 0.77 (0.75-0.79), and 0.85 (0.81-0.87), respectively. For CA19-9, the SEN, SPE and AUC were 0.78 (0.75-0.80), 0.90 (0.85-0.94) and 0.85 (0.82-0.88), respectively. The combination of miRNAs and CA19-9 greatly improved the SEN, SPE and AUC to 0.84 (0.80-0.87), 0.91 (0.89-0.93) and 0.94 (0.92-0.96), respectively. Moreover, circulating miRNAs also yielded an acceptable diagnostic accuracy for early-stage PC with a SEN of 0.79 (0.76-0.82), a SPE of 0.74 (0.68-0.79) and an AUC of 0.81 (0.77-0.84).Conclusions: Circulating miRNAs exhibited satisfactory diagnostic performance for PC and even early-stage PC. The combination of circulating miRNAs and the traditional marker CA19-9 can further improve the diagnostic accuracy, providing a novel strategy for PC diagnosis.

Download Full-text

Diagnostic value of NPTX2 (neuronal pentraxin II) methylation in patients with pancreatic cancer: meta-analysis

10.22541/au.160028144.47547692 ◽

2020 ◽

Author(s):

wenqi huang ◽

lifeng xue ◽

haoming xu ◽

jing xu ◽

hailan zhao ◽

...

Keyword(s):

Pancreatic Cancer ◽

Meta Analysis ◽

Diagnostic Value ◽

Neuronal Pentraxin

Download Full-text

Diagnostic Value of Plasma miR-181b, miR-196a, and miR-210 Combination in Pancreatic Cancer

Gastroenterology Research and Practice ◽

10.1155/2020/6073150 ◽

2020 ◽

Vol 2020 ◽

pp. 1-6

Author(s):

Gongpan Liu ◽

Cunhua Shao ◽

Anyun Li ◽

Xiaobin Zhang ◽

Xingjun Guo ◽

...

Keyword(s):

Pancreatic Cancer ◽

Vascular Invasion ◽

Operating Characteristic ◽

Clinical Stage ◽

Diagnostic Value ◽

Carbohydrate Antigen ◽

Plasma Samples ◽

Healthy Individuals ◽

Qrt Pcr ◽

Node Metastasis

Purpose. This study was aimed at investigating the roles of plasma miR-181b, miR-196a, and miR-210 in the diagnosis of pancreatic cancer (PC). Methods. Plasma samples were isolated from 40 patients with PC and 40 healthy individuals, respectively. The expression of miR-181b, miR-196a, and miR-210 was detected by qRT-PCR. The level of carbohydrate antigen 199 (CA199) was measured by an electrochemiluminescence (ECL) assay. The receiver operating characteristic (ROC) curve was used to analyze the diagnostic value of miR-181b, miR-196a, miR-210, CA199, and their combinations in PC. Results. The expression of plasma miR-181b, miR-196a, and miR-210 was significantly upregulated in PC patients. The plasma level of CA199 was also significantly increased in PC patients. The expression of miR-181b, miR-196a, and miR-210 was closely associated with lymph node metastasis, clinical stage, and vascular invasion but not correlated with age, gender, and tumor size. miR-181b, miR-196a, and miR-210 have lower AUC than CA199 in the diagnosis of PC. miR-181b+miR-210 and miR-196a+miR-210 also have lower AUC than CA199. It is worth noting that miR-181b+miR-196a+miR-210 has a higher AUC than CA199 in the diagnosis of PC. Conclusion. The combination of plasma miR-181b, miR-196a, and miR-210 had a good diagnostic value for PC.

Download Full-text