Editorial and Review: 33rd Asilomar Conference on Mass Spectrometry—Impact of Metabolomics in Translational and Clinical Research

2018 ◽  
Vol 30 (2) ◽  
pp. 199-202
Author(s):  
Tim Garrett ◽  
Chris Petucci
Keyword(s):  
Mass Spectrometry ◽  
Clinical Research ◽  
Asilomar Conference

scholarly journals Relevant phosphoproteomic and mass spectrometry: approaches useful in clinical research

2012 ◽  
Vol 1 (1) ◽  
Author(s):  
Elena López ◽  
Sarbelio Rodríguez Muñoz ◽  
Juan López Pascual ◽  
Luis Madero
Keyword(s):  
Mass Spectrometry ◽  
Clinical Research

The Proteomics and Metabolomics of Pain

2018 ◽  
pp. 850-875 ◽  
Author(s):  
David Gomez-Varela ◽  
Manuela Schmidt
Keyword(s):  
Mass Spectrometry ◽  
Clinical Practice ◽  
Clinical Research ◽  
Molecular Data ◽  
Integrated Analysis ◽  
Pain Medicine ◽  
Disease Networks ◽  
Pain Syndromes ◽  
Underlying Mechanisms ◽  
Definition Of

This article critically discusses the opportunities and challenges of proteomics and metabolomics in the context of pain research and clinical practice. Painful pathologies are extremely complex and often inadequately managed. In order to significantly improve therapeutic options of pain syndromes, a system-wide analysis of the underlying mechanisms is fundamental. To this end, the article highlights the potential of firmly integrating proteomics and metabolomics into the pain researcher’s toolbox. The article introduces technological aspects of mass spectrometry and also associated stumbling blocks for its standardization in clinical research. Lastly, it outlines the path towards personalized systems pain medicine via the definition of pain phenomes—from multilayered molecular data to phenotypical profiles and integrated analysis of disease networks.

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