Association between single nucleotide polymorphisms (SNPs) in the gene of ADP-ribosylation factor-like 15 (ARL15) and type 2 diabetes (T2D) in Korean Chinese population in Yanbian, China

2015 ◽  
Vol 37 (2) ◽  
pp. 124-128
Author(s):  
Zhengwei Cui ◽  
Tianxin Sheng ◽  
Yuping Wang ◽  
Wenjing Zhou ◽  
Weijie Wang ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Single Nucleotide Polymorphisms ◽  
Chinese Population ◽  
Nucleotide Polymorphisms ◽  
Single Nucleotide ◽  
Adp Ribosylation ◽  
Korean Chinese ◽  
Adp Ribosylation Factor

scholarly journals Association between single nucleotide polymorphisms in CDKAL1 and HHEX and type 2 diabetes in Chinese Population

2020 ◽  
Author(s):  
Chuanyin Li ◽  
Keyu Shen ◽  
Man Yang ◽  
Ying Yang ◽  
Wenyu Tao ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Insulin Secretion ◽  
Single Nucleotide Polymorphisms ◽  
Chinese Population ◽  
Haplotype Analysis ◽  
Nucleotide Polymorphisms ◽  
Single Nucleotide ◽  
Genotype Frequencies ◽  
Inheritance Model

Abstract Background: Type 2 diabetes mellitus (T2DM) has a high global prevalence, and the interaction of environmental factors and genetic factors may contribute to the risk of T2DM. We aimed to investigate the association between T2DM and the single nucleotide polymorphisms (SNPs) in genes associated with insulin secretion is necessary. Methods: T2DM (1169) and nondiabetic (NDM) (1277) subjects were enrolled and the eight SNPs in CDKAL1 and HHEX associated with insulin secretion were genotyped in a Chinese population.Results: Our result revealed that four SNPs (rs4712524, rs10946398, rs7754840 in CDKAL1 and rs5015480 in HHEX) showed significantly different genotype frequencies in the T2DM and NDM groups (P<0.00625). The G allele of rs4712524(P=0.004, OR=1.184; 95%CI: 1.057-1.327) , C allele of rs10946398(P<0.001, OR=1.247; 95%CI: 1.112-1.398) and C allele of rs775480 in CDKAL1 (P<0.001, OR=1.229; 95%CI: 1.096-1.387) functioned as risk allele in incidence of T2DM. The C allele of rs5015480 in HHEX (P<0.001, OR=1.295; 95%CI: 1.124-1.493) was risk factor for the development of T2DM. The haplotype analysis revealed that rs4712524-rs10946398-rs7754840-rs9460546GCCG (P=0.001, OR=1.210; 95%CI: 1.076-1.360) was associated with a greater risk of T2DM development. Moreover, The HHEX rs1111875-rs5015480 haplotype analysis with D’>0.9 showed that rs1111875-rs5015480CC was associated with development of T2DM(P=2.63×10-5, OR=1.364; 95%CI:1.180-1.576). In the inheritance models analysis, the best fit inheritance model for rs4712524, rs10946398, and rs7754840 in CDKAL1 and rs5015480 in HHEX were all log-additive. Conclusion: Our results revealed that genetic variations in CDKAL1 and HHEX were associated with T2DM susceptibility in a Chinese population.

scholarly journals AHSG Tag Single Nucleotide Polymorphisms Associate With Type 2 Diabetes and Dyslipidemia: Studies of Metabolic Traits in 7,683 White Danish Subjects

Diabetes ◽  
2008 ◽  
Vol 57 (5) ◽  
pp. 1427-1432 ◽  
Author(s):  
G. Andersen ◽  
K. S. Burgdorf ◽  
T. Sparso ◽  
K. Borch-Johnsen ◽  
T. Jorgensen ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Single Nucleotide Polymorphisms ◽  
Nucleotide Polymorphisms ◽  
Single Nucleotide ◽  
Metabolic Traits
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