Population pharmacokinetic analysis of lornoxicam in healthy Korean males considering creatinine clearance and CYP2C9 genetic polymorphism

2021 ◽  
Author(s):  
Seung-Hyun Jeong ◽  
Ji-Hun Jang ◽  
Yong-Bok Lee
Keyword(s):  
Genetic Polymorphism ◽  
Creatinine Clearance ◽  
Population Pharmacokinetic Analysis ◽  
Pharmacokinetic Analysis ◽  
Population Pharmacokinetic

scholarly journals Population Pharmacokinetics of Vancomycin in the Pediatric Cardiac Surgical Population

2019 ◽  
Vol 24 (2) ◽  
pp. 107-116 ◽  
Author(s):  
Brady S. Moffett ◽  
Karla Resendiz ◽  
Jennifer Morris ◽  
Ayse Akcan-Arikan ◽  
Paul A. Checchia
Keyword(s):  
Serum Concentration ◽  
Creatinine Clearance ◽  
Cardiac Surgical Procedures ◽  
Population Pharmacokinetic Analysis ◽  
Pharmacokinetic Analysis ◽  
Population Pharmacokinetic ◽  
Pharmacokinetic Data ◽  
Population Pharmacokinetic Study ◽  
Postmenstrual Age ◽  
Dosing Strategy

OBJECTIVE Vancomycin is often used in the pediatric cardiac surgical population, but few pharmacokinetic data are available to guide dosing. METHODS A retrospective, population pharmacokinetic study was performed for patients <19 years of age initiated on vancomycin after cardiac surgery in the cardiac intensive care unit from 2011–2016 in our institution. Patient data were summarized by using descriptive statistical methods, and population pharmacokinetic analysis was performed by using NONMEM. Simulation was performed to determine a dosing strategy that most frequently obtained an AUC0–24:MIC (minimum inhibitory concentration) ratio of >400. RESULTS A total of 261 patients (281 cardiac surgical procedures, cardiopulmonary bypass 82.3%) met inclusion criteria (60.1% male, median age 0.31 [IQR, 0.07–0.77] years). Vancomycin (14.5 ± 1.7 mg/kg/dose) was administered at median postoperative day 9 (IQR, 4–14), with a mean serum concentration of 11.5 ± 5.5 mg/L at 8.9 ± 3.8 hours after a dose. Population pharmacokinetic analysis demonstrated that a 1-compartment proportional error model with allometrically scaled weight best fit the data, with creatinine clearance and postmenstrual age as significant covariates. Simulation identified that a dosing regimen of 20 mg/kg/dose every 8 hours was most likely to achieve an AUC0–24:MIC ratio > 400 at a mean trough serum concentration of 12.9 ± 3.2 mg/L. CONCLUSIONS Vancomycin dosing in the postoperative pediatric cardiac surgical population should incorporate postmenstrual age and creatinine clearance. A vancomycin dose of 20 mg/kg every 8 hours is a reasonable empiric strategy.

scholarly journals Population Pharmacokinetic Analysis of Ceftobiprole for Treatment of Complicated Skin and Skin Structure Infections

2008 ◽  
Vol 53 (3) ◽  
pp. 1228-1230 ◽  
Author(s):  
Holly Kimko ◽  
Bindu Murthy ◽  
Xu Xu ◽  
Partha Nandy ◽  
Richard Strauss ◽  
...  
Keyword(s):  
Renal Function ◽  
Renal Impairment ◽  
Creatinine Clearance ◽  
Normal Renal Function ◽  
Population Pharmacokinetic Analysis ◽  
Pharmacokinetic Analysis ◽  
Population Pharmacokinetic ◽  
Skin Structure ◽  
Complicated Skin

ABSTRACT Population pharmacokinetic analysis demonstrated that renal function, as assessed by creatinine clearance (CLCR), was the patient characteristic that had a clinically relevant impact on ceftobiprole pharmacodynamics. Dosing adjustments based on CLCR for subjects with renal impairment should provide ceftobiprole exposure similar to that in patients with normal renal function.

Population Pharmacokinetic Analysis of Panitumumab in Patients With Advanced Solid Tumors

2009 ◽  
Vol 49 (10) ◽  
pp. 1142-1156 ◽  
Author(s):  
Peiming Ma ◽  
Bing-Bing Yang ◽  
Yow-Ming Wang ◽  
Mark Peterson ◽  
Adimoolam Narayanan ◽  
...  
Keyword(s):  
Solid Tumors ◽  
Population Pharmacokinetic Analysis ◽  
Pharmacokinetic Analysis ◽  
Population Pharmacokinetic ◽  
Advanced Solid Tumors
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