Can SGLT2 Inhibitors Cause Acute Renal Failure? Plausible Role for Altered Glomerular Hemodynamics and Medullary Hypoxia

Drug Safety ◽  
2017 ◽  
Vol 41 (3) ◽  
pp. 239-252 ◽  
Author(s):  
Auryan Szalat ◽  
Amichai Perlman ◽  
Mordechai Muszkat ◽  
Mogher Khamaisi ◽  
Zaid Abassi ◽  
...  
Keyword(s):  
Renal Failure ◽  
Acute Renal Failure ◽  
Sglt2 Inhibitors ◽  
Glomerular Hemodynamics

scholarly journals Nephrotoxicity of acyclovir and ganciclovir in rats: evaluation of glomerular hemodynamics.

1997 ◽  
Vol 8 (3) ◽  
pp. 361-367
Author(s):  
M de F Dos Santos ◽  
O F Dos Santos ◽  
M A Boim ◽  
C V Razvickas ◽  
L A de Moura ◽  
...  
Keyword(s):  
Renal Failure ◽  
Acute Renal Failure ◽  
Kidney Function ◽  
Term Treatment ◽  
Urinary Flow ◽  
Short Term ◽  
Short Term Treatment ◽  
Chronic Group ◽  
Acute Group ◽  
Glomerular Hemodynamics

Whole-kidney function and glomerular hemodynamics were evaluated after acute (50 mg/kg, iv, in bolus) and short-term chronic (50 mg mg/kg, ip, 5 days) acyclovir (ACV) and short-term chronic ganciclovir (Gan; 30 mg/kg, ip, 5 days) treatment in envolemic Munich-Wistar rats. The evaluation of whole-kidney function of the ACV groups showed a significant reduction in total GFR (0.96 +/- 0.10 to 0.28 +/- 0.02 mL/min in the acute group, P < 0.05, and 1.04 +/- 0.09 to 0.33 +/- 0.04 mL/min in the chronic group, P < 0.05) with a marked increase in total renal vascular resistance (TRVR) (33 +/- 5 to 122 +/- 26 mm Hg.min/mL in the acute group and 28 +/- 3 to 74 +/- 18 mm Hg.min/mL in the chronic group, P < 0.05) and a reduction in RPF (2.29 +/- 0.25 to 0.81 +/- 0.15 mL/min in the acute group and 2.57 +/- 0.36 to 1.30 +/- 0.40 mL/min in the chronic group, P < 0.05). Conversely, urinary flow (V') was unchanged (3.6 +/- 0.4 to 3.6 +/- 0.2 microL/min in the acute group) or elevated (3.7 +/- 0.6 to 6.6 +/- 1.4 microL/min in the chronic group, P < 0.05). The evaluation of glomerular hemodynamics after ACV treatment showed a reduction in single-nephron GFR (SNGFR) (46.4 +/- 5.3 to 26.2 +/- 3.4 nL/min in the acute group and 38.7 +/- 5.7 to 21.1 +/- 5.7 nL/min in the chronic group, P < 0.05), a significant elevation in total arteriolar resistance (RT) (2.90 +/- 0.44 to 4.94 +/- 0.77 x 10(10) dyn.s.cm-5 in the acute group and 3.72 +/- 0.45 to 9.00 +/- 2.40 x 10(10) dyn.s.cm-5 in the chronic group, P < 0.05) and a severe reduction in glomerular plasma flow rate (QA) (152.6 +/- 29.5 to 103.8 +/- 27.8 nL/min in the acute group and 149.1 +/- 29.8 to 68.5 +/- 10.0 nL/min in the chronic group, P < 0.05). However, the glomerular ultrafiltration coefficient, Kf, was changed only in the chronic group (0.1002 +/- 0.0165 to 0.0499 +/- 0.0090 nL/(s.mm Hg), P < 0.05). After Gan treatment, no changes were observed in GFR (1.04 +/- 0.09 to 0.96 +/- 0.08 mL/min, with the maintenance of RPF (2.57 +/- 0.36 to 2.66 +/- 0.34 mL/min) and a nonsignificant reduction in TRVR (28 +/- 3 to 20 +/- 3 mm Hg.min/mL. The short-term Gan treatment also showed a different pattern in glomerular hemodynamics by inducing an elevation in SNGFR (38.7 +/- 5.7 to 50.3 +/- 2.8 nL/min, P < 0.05) with no changes in QA (150 +/- 30 to 135 +/- 22 nL/min) and a mild vasodilation, RT (3.7 +/- 0.5 to 2.7 +/- 0.3 x 10(10) dyn.s.cm-5, P < 0.05) associated with an increment in Kf (0.1002 +/- 0.0165 to 0.2400 +/- 0.0700 nL/(s.mm Hg), P < 0.05). Thus, ACV induced acute renal failure by reducing GFR and SNGFR by an increase in TRVR and RT with a reduction in RPF and QA. Also, after short-term treatment with ACV, a reduction in Kf led to a reduction of SNGFR. On the other hand, Gan treatment did not induce acute renal failure by the adopted techniques.

scholarly journals Glomerular hemodynamics in mercury-induced acute renal failure

1987 ◽  
Vol 32 (2) ◽  
pp. 246-255 ◽  
Author(s):  
Allen I. Wolfert ◽  
Leigh A. Laveri ◽  
Katherine M. Reilly ◽  
Keith R. Oken ◽  
Donald E. Oken
Keyword(s):  
Renal Failure ◽  
Acute Renal Failure ◽  
Glomerular Hemodynamics

Glomerular Hemodynamics in Acute Renal Failure

Renal Failure ◽  
1997 ◽  
Vol 19 (2) ◽  
pp. 209-212 ◽  
Author(s):  
Mirian A. Boim ◽  
Oscar F. Pavão dos Santos ◽  
Elvino J.G. Barros ◽  
Nestor Schor
Keyword(s):  
Renal Failure ◽  
Acute Renal Failure ◽  
Glomerular Hemodynamics
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