scholarly journals Sex Differences in Association Between Anti-Hypertensive Medications and Risk of COVID-19 in Middle-Aged and Older Adults

Drugs & Aging ◽  
2021 ◽  
Author(s):  
Yue Ma ◽  
Yuan Zhang ◽  
Shu Li ◽  
Hongxi Yang ◽  
Huiping Li ◽  
...  
Keyword(s):  
Older Adults ◽  
Sex Differences ◽  
Middle Aged

037 Subjective sleep and objective cognition in middle-aged and older adults: Does sex matter?

SLEEP ◽  
2021 ◽  
Vol 44 (Supplement_2) ◽  
pp. A16-A16
Author(s):  
Ashley Curtis ◽  
Anthony Schmiedeler ◽  
Sadhika Jagannathan ◽  
Maggie Connell ◽  
Angela Atkinson ◽  
...  
Keyword(s):  
Older Adults ◽  
Working Memory ◽  
Sex Differences ◽  
Cognitive Impairment ◽  
Reaction Time ◽  
Sleep Quality ◽  
Sleep Duration ◽  
Sleep Efficiency ◽  
Attentional Orienting ◽  
Middle Aged

Abstract Introduction Worse sleep has been linked to cognitive dysfunction in aging populations. There are known sex differences in the prevalence and presentation of both sleep disturbance and cognitive impairment, but research investigating sex differences in the associations between sleep and objective cognition is limited and inconclusive. We examined sex as a moderator of associations between self-reported sleep and objective cognitive performance in middle-aged/older adults. Methods Sixty-four adults aged 50+ (Mage= 63.8, SD=7.7; 33 men/31 women) who were cognitively healthy (no mild cognitive impairment, dementia or neurological disorders) completed an online survey (via Qualtrics) measuring self-reported sleep (Pittsburgh Sleep Quality Index; PSQI). Participants completed online cognitive tasks (via Inquisit) measuring inhibition (Stroop task; interference reaction time scores), attentional orienting (Posner Endogenous Cueing Task; reaction time difference between invalidly cued and validly cued trials), and working memory (Sternberg task; proportion correct). Multiple regressions examined whether PSQI subscores (sleep quality, sleep duration, sleep efficiency) were independently associated with or interacted with sex in their associations with cognition, controlling for age and education. Results Sex interacted with sleep quality in the association with endogenous attentional orienting (p=.01, R-squared=.10). Specifically, worse sleep quality was associated with worse attentional orienting in women (B=22.73, SE=9.53, p=.02) but not men (p=.24). Sex interacted with PSQI-sleep duration (p=.03, R-squared=.08) and PSQI-sleep efficiency (p=.03, R-squared=.08) in the association with inhibition performance. Specifically, worse sleep duration (B=235.28, SE=77.51, p=.004) and sleep efficiency (B=211.73, SE=68.70, p=.003) were associated with worse interference scores in men but not women (ps>.05). No variables were associated with working memory. Conclusion In middle-aged and older adults, sex moderates associations between self-reported sleep and objective cognition, depending on the sleep parameter and cognitive ability assessed. Findings suggest that women are more vulnerable to the effects of poor sleep quality on spatial attention, whereas men are more vulnerable to the effects of shorter sleep duration and worse overall sleep fragmentation on ability to inhibit task-irrelevant stimuli. Future studies should investigate sex-specific associations between sleep and cognition over time in order to better understand the prospective trajectories of these processes during aging. Support (if any):

scholarly journals Sex differences in the non-linear association between BMI and LDL cholesterol in middle-aged and older adults: findings from two nationally representative surveys in China

2021 ◽  
Vol 20 (1) ◽  
Author(s):  
Haibin Li ◽  
Jiahui Ma ◽  
Deqiang Zheng ◽  
Xia Li ◽  
Xiuhua Guo ◽  
...  
Keyword(s):  
Older Adults ◽  
Sex Differences ◽  
Smoking Status ◽  
Generalized Additive Models ◽  
Additive Models ◽  
Middle Aged ◽  
Linear Association ◽  
Non Linear ◽  
Males And Females ◽  
Nationally Representative

Abstract Background The relationship between body mass index (BMI) and low-density lipoprotein cholesterol (LDL-C) has not been clearly elucidated in middle-aged and older adults. This study aimed to evaluate the non-linear dose-response relationship between BMI and LDL-C in males and females. Methods Data was obtained from two nationally representative surveys in China—the China Health and Nutrition Survey (CHNS, 2009) and China Health and Retirement Longitudinal Study (CHARLS, 2011–2012). To evaluate the sex differences in the association between BMI and LDL-C, the generalized additive models with a smooth function for continuous BMI and smooth-factor interaction for sexes with BMI were used. Segmented regressions were fitted to calculate the slopes with different estimated breakpoints among females and males. Results A total of 12,273 participants (47.1% male) aged 45 to 75 years were included. The generalized additive models revealed that a non-linear relationship between BMI and LDL-C level in both sexes after adjustment for age, residence, education levels, marital status, drinking, smoking status, and cohort (CHNS or CHARLS). Slopes of the association between BMI and LDL-C association changed at BMI 20.3 kg/m2 (95% CI: 18.8 to 21.8) in females and 27.1 kg/m2 (95% CI: 25. 8 to 28.4) in males. Below these BMI breakpoints, LDL-C levels increased 1.84 (95% CI: 1.45 to 2.31) in males and 3.49 (95% CI: 1.54 to 5.45) mg/dL per kg/m2 in females. However, LDL-C levels declined − 1.50 (95% CI: − 2.92 to − 0.09) mg/dL per kg/m2 above BMI of 27.1 kg/m2 in males. The non-linear association BMI and LDL-C in males and females was varied by cohort source, age groups, and the number of metabolic syndrome criteria. Conclusions In the Chinese middle aged and older adults, the BMI and LDL-C relationship was inverted U-shaped with a high level of LDL-C at a BMI of 27.1 kg/m2 in males, and an approximately linear association was observed in females.

Risk indicators of edentulism, partial tooth loss and prosthetic status among black and white middle-aged and older adults

2001 ◽  
Vol 29 (5) ◽  
pp. 329-340 ◽  
Author(s):  
Teresa A. Dolan ◽  
Gregg H. Gilbert ◽  
R. Paul Duncan ◽  
Ulrich Foerster
Keyword(s):  
Older Adults ◽  
Tooth Loss ◽  
Risk Indicators ◽  
Middle Aged ◽  
Black And White ◽  
Prosthetic Status

Age and recognition for one’s creative hobby are associated with fewer depressive symptoms in middle-aged and older adults.

2020 ◽  
Author(s):  
Sarah M. Israel ◽  
Carolyn E. Adams-Price ◽  
Courtney J. Bolstad ◽  
Danielle K. Nadorff
Keyword(s):  
Older Adults ◽  
Depressive Symptoms ◽  
Middle Aged

Unpleasant Situations Generate Negative Affect for Younger and Middle-Aged Adults, But Not Older Adults

2013 ◽  
Author(s):  
M. C. Voelkle ◽  
N. C. Ebner ◽  
U. Lindenberger ◽  
M. Riediger
Keyword(s):  
Older Adults ◽  
Negative Affect ◽  
Middle Aged ◽  
Middle Aged Adults

Study finds racial/ethnic disparities in depressive trajectories among middle-aged or older adults

2012 ◽  
Author(s):  
J. Liang ◽  
X. Xu ◽  
A. R. Quinones ◽  
J. M. Bennett ◽  
W. Ye
Keyword(s):  
Older Adults ◽  
Ethnic Disparities ◽  
Middle Aged ◽  
Racial Ethnic

Social Support and Depression in LGB Middle-Aged and Older Adults With Internalized Homophobia

2012 ◽  
Author(s):  
Jonathan J. W. Mueller ◽  
Nicole D. Ng ◽  
Hilary Sluis ◽  
Louis Y. Stephenson ◽  
Wendy Ratto ◽  
...  
Keyword(s):  
Social Support ◽  
Older Adults ◽  
Internalized Homophobia ◽  
Middle Aged
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