Multiscale design and biomechanical evaluation of porous spinal fusion cage to realize specified mechanical properties

Author(s):  
Hongwei Wang ◽  
Yi Wan ◽  
Quhao Li ◽  
Xinyu Liu ◽  
Mingzhi Yu ◽  
...  
2020 ◽  
pp. 088532822097849
Author(s):  
Xiao Han ◽  
Yuan Gao ◽  
Yilei Ding ◽  
Weijie Wang ◽  
Li Liu ◽  
...  

Spinal fusion cages are commonly used to treat spinal diseases caused by degenerative changes, deformities, and trauma. At present, most of the main clinical spinal fusion cage products are non-degradable and still cause some undesirable side effects, such as the stress shielding phenomenon, interference with postoperative medical imaging, and obvious foreign body sensation in patients. Degradable spinal fusion cages have promising potential with extensive perspectives. The purpose of this study was to fabricate a degradable spinal fusion cage from both polycaprolactone (PCL) and high-proportion beta-tricalcium phosphate (β-TCP), using the highly personalised, accurate, and rapid fused deposition modelling 3 D printing technology. PCL and β-TCP were mixed in three different ratios (60:40, 55:45, and 50:50). Both in vitro degradation and cell experiments proved that all cages with the different PCL:β-TCP ratios met the mechanical properties of human cancellous bone while maintaining their structural integrity. The biological activity of the cages improved with higher amounts of the β-TCP content. This study also showed that a spinal fusion cage with high β-TCP content and suitable mechanical properties can be manufactured using extruding rods and appropriate models, providing a new solution for the design of degradable spinal fusion cages.


Author(s):  
F Jabbary Aslani ◽  
DWL Hukins ◽  
DET Shepherd ◽  
JJ Parry ◽  
AJ Fennell ◽  
...  

2004 ◽  
Vol 2004.5 (0) ◽  
pp. 147-148
Author(s):  
Mika MURAI ◽  
Jun-ichi SHIBANO ◽  
Shigeru TADANO ◽  
Akihisa ATOU ◽  
Satoshi ASANO

Author(s):  
Theresa Kauth ◽  
Christian Hopmann ◽  
Bernd Kujat ◽  
Friedrich W. Bach ◽  
Bastian Welke ◽  
...  

AbstractConventional fusion devices (“cages”) are often used to join two vertebrae of the human spine and generally remain in the body for a lifetime and can theoretically lead to any complications. Therefore, an absorbable hybrid fusion cage consisting of a magnesium skeleton infiltrated with an absorbable polymer [poly-ε-caprolactone (PCL)] has been developed. The primary objective of the cage is to ensure an adequate stiffness of the disc space directly after the operation and to encourage the ingrowth of the new bone tissue to secure long life stability. Once a sufficiently rigid bone connection is formed, the implant should be absorbed. The purpose of this first study on the new absorbable fusion cage was to investigate the mechanical properties


2001 ◽  
Vol 15 (1) ◽  
pp. 1-6 ◽  
Author(s):  
Toshiyuki Takahashi ◽  
Teiji Tominaga ◽  
Toshimitu Yokobori ◽  
Takashi Yoshimoto

Author(s):  
F. Jabbary Aslani ◽  
D. W. L. Hukins ◽  
D. E. T. Shepherd
Keyword(s):  

Biomaterials ◽  
2014 ◽  
Vol 35 (22) ◽  
pp. 5647-5659 ◽  
Author(s):  
Yi Li ◽  
Zhi-gang Wu ◽  
Xiao-kang Li ◽  
Zheng Guo ◽  
Su-hua Wu ◽  
...  

2015 ◽  
Vol 15 (06) ◽  
pp. 1540052
Author(s):  
QIGUO RONG ◽  
JIANFENG BAI ◽  
YONGLING HUANG ◽  
JIANHAO LIN

For patients with severe joint deformity or defect, the conventional knee implant cannot meet the installation requirements. A patient-specific prosthesis is a rational choice for these patients. The purpose of this study was to develop a patient-specific knee implant and evaluate its mechanical properties. A mobile-bearing type of knee implant was designed for a young patient with severe rheumatoid arthritis. The stress characteristics were studied by the finite element (FE) method. Results show that the stress distribution of the mobile-bearing knee implant is much better than that of a hinged knee implant designed before. But the stability of the mobile-bearing knee implant should be investigated in more detail before its application.


2018 ◽  
Vol 12 (5) ◽  
pp. 1149-1162 ◽  
Author(s):  
Xiurong Ke ◽  
Lei Zhang ◽  
Xianyan Yang ◽  
Juncheng Wang ◽  
Chen Zhuang ◽  
...  

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