A prospective, double-blind, randomized comparison of prophylactic intramyometrial 15-methyl prostaglandin F2α, 125 micrograms, and intravenous oxytocin, 20 units, for the control of blood loss at elective cesarean section

1994 ◽  
Vol 171 (5) ◽  
pp. 1356-1360 ◽  
Author(s):  
Min M. Chou ◽  
Ian Z. MacKenzie
Keyword(s):  
Blood Loss ◽  
Cesarean Section ◽  
Prostaglandin F2α ◽  
Elective Cesarean Section ◽  
Double Blind ◽  
Elective Cesarean

scholarly journals Efficacy of Phenylephrine in Preventing Hemodynamic Responses of Oxytocin during Elective Cesarean Section: A Randomized, Double-Blind, Controlled Trial

2019 ◽  
Vol 55 (01) ◽  
pp. 048-053
Author(s):  
Medha Mohta ◽  
Vijay Kumar ◽  
Rachna Agarwal ◽  
Geetanjali T. Chilkoti ◽  
Sakshi Duggal
Keyword(s):  
Cesarean Section ◽  
Normal Saline ◽  
Controlled Trial ◽  
Saline Group ◽  
Elective Cesarean Section ◽  
Hemodynamic Changes ◽  
Singleton Pregnancy ◽  
Double Blind ◽  
Elective Cesarean ◽  
Better Than

AbstractThis study compared hemodynamic changes and occurrence of complications following oxytocin administration with a prior injection of phenylephrine 100 μg or normal saline during elective cesarean section. Sixty-six healthy term parturients with uncomplicated, singleton pregnancy undergoing elective cesarean section under spinal anesthesia were studied. They received either intravenous phenylephrine 100 μg or normal saline before oxytocin 3 IU was administered over 30 seconds. Oxytocin dose was repeated depending on the adequacy of uterine tone. There was no significant change in systolic, diastolic, and mean arterial pressures during the initial 3 minutes following oxytocin administration in the phenylephrine group but a significant fall in mean and diastolic pressures in the saline group. Heart rate did not change significantly, and no significant complications occurred in either of the groups. To conclude, phenylephrine 100 μg administered before oxytocin injection maintained hemodynamic parameters better than normal saline injection during elective cesarean section.

scholarly journals Tranexamic acid in prevention of postpartum hemorrhage in elective cesarean section

2019 ◽  
Vol 8 (2) ◽  
pp. 372
Author(s):  
Pravin Shah ◽  
Ajay Agrawal ◽  
Shailaja Chhetri ◽  
Pappu Rijal ◽  
Nisha K. Bhatta
Keyword(s):  
Blood Loss ◽  
Cesarean Section ◽  
Tranexamic Acid ◽  
Postpartum Hemorrhage ◽  
Elective Cesarean Section ◽  
Controlled Study ◽  
Control Group ◽  
Estimated Blood Loss ◽  
Elective Cesarean ◽  
The Mean

Background: Postpartum hemorrhage is a common and occasionally life-threatening complication of labor. Cesarean section is associated with more blood loss in compared to vaginal delivery. Despite, there is a trend for increasing cesarean section rates in both developed and developing countries thereby increasing the risk of morbidity and mortality, especially among anemic women. The objective of this study was to evaluate the effect of preoperative administration of intravenous Tranexamic acid on blood loss during and after elective cesarean section.Methods: This was a prospective, randomized controlled study with 160 eligible pregnant women of 37 or more period of gestation. They were all planned for elective cesarean section and were randomized into two groups either to receive 10ml (1gm) of Tranexamic acid intravenously or 10ml of normal saline. Blood loss was measured during and for 24 hours after operation.Results: The mean estimated blood loss was significantly lower in women treated with Tranexamic acid compared with women in the placebo group (392.13 ml±10.06 vs 498.69 ml±15.87, respectively; p<0.001). The mean difference in pre-operative and post-operative hemoglobin levels was statistically significant in the Tranexamic acid group than in the control group (0.31±0.18 vs 0.79±0.23, respectively; p<0.001).Conclusions: Pre-operative use of Tranexamic acid is associated with reduced blood loss during and after elective cesarean section. In a developing country like ours where postpartum hemorrhage is a major threat to the life of the mothers, it seems to be a promising option.

scholarly journals Randomized double-blind comparison of the effects of intramyometrial and intravenous oxytocin during elective cesarean section

2016 ◽  
Vol 42 (4) ◽  
pp. 404-409 ◽  
Author(s):  
Chieko Akinaga ◽  
Sakiko Uchizaki ◽  
Tadayoshi Kurita ◽  
Mizuki Taniguchi ◽  
Hiroshi Makino ◽  
...  
Keyword(s):  
Cesarean Section ◽  
Elective Cesarean Section ◽  
Double Blind ◽  
Elective Cesarean ◽  
Blind Comparison

scholarly journals Comparison of Short Vs. Long Half-Life Single-Dose Prophylactic Antibiotics for Cesarean Section

1994 ◽  
Vol 2 (3) ◽  
pp. 120-125 ◽  
Author(s):  
Bernard Gonik ◽  
James McGregor
Keyword(s):  
Single Dose ◽  
Cesarean Section ◽  
Half Life ◽  
Study Groups ◽  
Elective Cesarean Section ◽  
Double Blind ◽  
Prophylactic Efficacy ◽  
Cord Clamping ◽  
Containment Measures ◽  
Elective Cesarean

Objective:Numerous studies demonstrate the efficacy of antibiotic prophylaxis for reducing postcesarean section infectious morbidity. The duration of therapy, however, remains controversial. Cost containment measures and the ease of single dosing have led to the introduction of “extended” half-life agents for cesarean-section chemoprophylaxis. We tested the hypothesis that there was no difference in efficacy between a single dose of a short half-life agent (cefoxitin) and a longer half-life agent (cefotetan).Methods:A prospective, double-blind trial of 375 non-elective cesarean-section cases was carried out. Study antibiotics (2 g) were administered intravenously (IV) at cord clamping only.Results:Demographic and clinical variables between the 2 study groups were similar. No significant differences were noted in major or minor morbidity or in infectious morbidities for patients receiving the 2 prophylactic regimens. The occurrence of postoperative endometritis was likewise similar for the subjects receiving cefoxitin (10%) and cefotetan (15%). When cases whose surgery lasted >60 min were evaluated separately, no differences in outcomes between the 2 groups were identifiedConclusions:These findings confirm our hypothesis that the half-life difference between these 2 agents does not impact on single-dose Prophylactic efficacy in cesarean section.

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