Preparation of multichain poly-α-amino acids and polypeptidyl proteins in dimethyl sulfoxide

Quinazoline skeletons are synthesized by amino acids catabolism/reconstruction combined with dimethyl sulfoxide insertion/cyclization for the first time. The amino acid acts as a carbon and nitrogen source through HI-mediated catabolism...

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ChemInform Abstract: TERT-BUTYL BROMIDE-DIMETHYL SULFOXIDE REACTIONS. PUMMERER-LIKE REACTION WITH CARBOXYLIC ACIDS AND N-PROTECTED AMINO ACIDS

Chemischer Informationsdienst ◽

10.1002/chin.198204132 ◽

1982 ◽

Vol 13 (4) ◽

Author(s):

A. DOSSENA ◽

R. MARCHELLI ◽

G. CASNATI

Keyword(s):

Amino Acids ◽

Dimethyl Sulfoxide ◽

Carboxylic Acids ◽

Butyl Bromide ◽

Tert Butyl

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Macroscopic and Microscopic Protonation Equilibria of Some α-Amino Acids in Dimethyl Sulfoxide–Water Mixtures

Journal of Solution Chemistry ◽

10.1007/s10953-015-0363-8 ◽

2015 ◽

Vol 44 (8) ◽

pp. 1705-1722

Author(s):

Alev Doğan ◽

Nazife Aslan ◽

Pınar E. Erden ◽

Esin Canel ◽

Esma Kılıç

Keyword(s):

Amino Acids ◽

Dimethyl Sulfoxide ◽

Protonation Equilibria

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The interaction of dimethyl sulfoxide with N-benzoyl amino acids

Australian Journal of Chemistry ◽

10.1071/ch9811869 ◽

1981 ◽

Vol 34 (9) ◽

pp. 1869 ◽

Cited By ~ 1

Author(s):

CW Fong ◽

HG Grant

Keyword(s):

Amino Acids ◽

Hydrogen Bonding ◽

Dimethyl Sulfoxide ◽

Benzene Ring ◽

Chemical Shifts ◽

Side Chain ◽

Torsional Angle ◽

Intermolecular Hydrogen Bonding ◽

Atom Increase ◽

Self Association

The interaction of dimethyl sulfoxide with N-benzoyl amino acids in deuterochloroform has been investigated by 13C n.m.r. spectroscopy. Examination of the chemical shifts of the benzene ring reveals that intermolecular hydrogen bonding between dimethyl sulfoxide and the amido-hydrogen atom increase the effective steric size of the amino hydrogen, resulting in an increase in the torsional angle between the benzene ring and the C(O)NHCH(R)COOH side chain. Self-association of N- benzoyl amino acids in deuterochloroform occurs largely through two COOH...O=C hydrogen bonds and does not involve intermolecular hydrogen bonding to the N-H proton.

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ChemInform Abstract: SOME ANALYTICAL APPLICATIONS OF CHLORAMINE-B: ESTIMATION OF AMINO ACIDS, DIMETHYL SULFOXIDE, HYDRAZINE SULFATE, SEMICARBAZIDE HYDROCHLORIDE AND CYANIDE AND THIOCYANATE IONS IN METAL SALTS AND COMPLEXES USING CHLORAMINE-B

Chemischer Informationsdienst ◽

10.1002/chin.198032345 ◽

1980 ◽

Vol 11 (32) ◽

Author(s):

RANGASWAMY RANGASWAMY ◽

H. S. YATHIRAJAN ◽

D. S. MAHADEVAPPA

Keyword(s):

Amino Acids ◽

Dimethyl Sulfoxide ◽

Metal Salts ◽

Hydrazine Sulfate ◽

Analytical Applications ◽

Semicarbazide Hydrochloride

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Uptake of the Herbicidal Glyphosate by Escherichia coli K-12

Bioscience Reports ◽

10.1023/a:1020198007883 ◽

1999 ◽

Vol 19 (1) ◽

pp. 43-49 ◽

Cited By ~ 3

Author(s):

Elena Cherepenko ◽

Oksana Karpenko

Keyword(s):

Escherichia Coli ◽

Amino Acids ◽

Dimethyl Sulfoxide ◽

Transport System ◽

Broad Spectrum ◽

Cell Resistance ◽

E Coli ◽

Dmso Treatment ◽

Successful Measurement ◽

K 12

The uptake of the aminoacid biosynthesis inhibitor, used as the broad-spectrum herbicide ingredient, glyphosate (N-[phosphonomethyl]-glycine) was investigated in E. coli as a model to study mechanisms of cell resistance to antimetabolites as drugs and pesticides. Unlike the glyphosate-degrading Arthrobacter sp. strain for which the first successful measurement of glyphosate uptake and its inhibition by orthophosphate was reported [15], E. coli K-12 cannot take up this inhibitor either in the presence of orthophosphate, or after a prolonged starvation for it. However, cells made “competent” after an overnight cold CaCl2 exposure followed by dimethyl sulfoxide (DMSO) treatment could take up this compound (Km for glyphosate uptake, 274 μM). Neither amino acids, belonging to a single transport system, nor orthophosphate gave essential inhibition of glyphosate uptake by these cells.

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Theoretical analysis of apical bonding in copper(II) chelates with amino acids

Journal of Applied Crystallography ◽

10.1107/s0021889809023589 ◽

2009 ◽

Vol 42 (5) ◽

pp. 793-797 ◽

Cited By ~ 1

Author(s):

Ante Miličević ◽

Nenad Raos

Keyword(s):

Amino Acids ◽

Theoretical Analysis ◽

Bond Length ◽

Dimethyl Sulfoxide ◽

Coordination Polyhedron ◽

Side Chain ◽

Naturally Occurring ◽

Steric Crowding ◽

Overlapping Spheres

The interdependence between the side of apical coordination (H2O, >C=O, dimethyl sulfoxide and Cl−) and steric crowding at the apical positions was investigated for a set of 20 copper(II) bis complexes with naturally occurring amino acids. As a measure of steric crowding the overlapping volumes,V*, were used, calculated by the modified overlapping spheres method. It was found that the apically coordinated side of a complex is more hindered by the side-chain atoms. In addition, if both sides are apically coordinated, the apical bond is shorter at the more crowded side. The interdependence between the length of the apical bond and distortion of the coordination polyhedron was also studied. The apical bond length shows sigmoidal dependence on the magnitude of distortion, and is also dependent on the kind of distortion (square-pyramidal or tetrahedral).

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