Characterization of the folate-binding proteins associated with the plasma membrane of rat liver

1988 ◽  
Vol 939 (3) ◽  
pp. 533-541 ◽  
Author(s):  
Maria da Costa ◽  
Sheldon P. Rothenberg
Keyword(s):  
Plasma Membrane ◽  
Rat Liver ◽  
Binding Proteins ◽  
Folate Binding Proteins

scholarly journals CHARACTERIZATION OF RAT LIVER SUBCELLULAR MEMBRANES

1974 ◽  
Vol 60 (2) ◽  
pp. 460-472 ◽  
Author(s):  
David H. DeHeer ◽  
Merle S. Olson ◽  
R. Neal Pinckard
Keyword(s):  
Plasma Membrane ◽  
Rat Liver ◽  
Nuclear Membrane ◽  
Membrane Fraction ◽  
Cross Reactivity ◽  
Selective Absorption ◽  
Mitochondrial Membranes ◽  
Subcellular Membrane ◽  
Hepatocellular Necrosis

The induction of acute hepatocellular necrosis in rats resulted in the production of complement fixing, IgM autoantibodies directed toward inner and outer mitochondrial membranes, microsomal membrane, lysosomal membrane, nuclear membrane, cytosol, but not to plasma membrane. Utilizing selective absorption procedures it was demonstrated that each subcellular membrane fraction possessed unique autoantigenic activity with little or no cross-reactivity between the various membrane fractions. It is proposed that the development of membrane-specific autoantibodies may provide an immunological marker useful in the differential characterization of various subcellular membranes.

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