This chapter reviews recent literature related to local anesthetic sympathetic ganglion blockade (SGB) in treatment of post-traumatic stress disorder (PTSD) and its effect on the overall function of patients, with specific emphasis on male sexual and marital function. This chapter also discusses a publically available video in which a patient who had the PTSD checklist (PCL) administered before, and following, SGB as well as his wife were interviewed. A 34 year-old male Army Ranger veteran who suffered severe PTSD with associated marital and sexual difficulties after deployment, the patient had reported decreased libido and avoidance of intimacy. After SGB, he noticed marked improvement of his PTSD symptoms and resolution of his sexual dysfunction and marital difficulties. His reported improvements were echoed by his wife. The chapter also discusses known mechanisms of sexual dysfunction as related to PTSD and sympathetic nerve blockade effects as related to the sympathetic nervous system.