Effect of optic nerve transection onN-acetylaspartylglutamate immunoreactivity in the primary and accessory optic projection systems in the rat

1991 ◽  
Vol 538 (1) ◽  
pp. 86-94 ◽  
Author(s):  
J.R. Moffett ◽  
L.C. Williamson ◽  
J.H. Neale ◽  
M. Palkovits ◽  
M.A.A. Namboodiri
Keyword(s):  
Optic Nerve ◽  
Nerve Transection ◽  
Optic Nerve Transection

scholarly journals Comparing modes of delivery of a combination of ion channel inhibitors for limiting secondary degeneration following partial optic nerve transection

2019 ◽  
Vol 9 (1) ◽  
Author(s):  
Lillian M. Toomey ◽  
Carole A. Bartlett ◽  
Nikolas Gavriel ◽  
Terence McGonigle ◽  
Maimuna Majimbi ◽  
...  
Keyword(s):  
Optic Nerve ◽  
Ion Channel ◽  
Local Delivery ◽  
Nerve Transection ◽  
Secondary Degeneration ◽  
Injury Site ◽  
Myelin Structure ◽  
Ion Channel Inhibitors ◽  
Optic Nerve Transection ◽  
Inhibitor Combination

Abstract Injury to the central nervous system is exacerbated by secondary degeneration. Previous research has shown that a combination of orally and locally administered ion channel inhibitors following partial optic nerve injury protects the myelin sheath and preserves function in the ventral optic nerve, vulnerable to secondary degeneration. However, local administration is often not clinically appropriate. This study aimed to compare the efficacy of systemic and local delivery of the ion channel inhibitor combination of lomerizine, brilliant blue G (BBG) and YM872, which inhibits voltage-gated calcium channels, P2X7 receptors and Ca2+ permeable α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors respectively. Following a partial optic nerve transection, adult female PVG rats were treated with BBG and YM872 delivered via osmotic mini pump directly to the injury site, or via intraperitoneal injection, both alongside oral administration of lomerizine. Myelin structure was preserved with both delivery modes of the ion channel inhibitor combination. However, there was no effect of treatment on inflammation, either peripherally or at the injury site, or on the density of oligodendroglial cells. Taken together, the data indicate that even at lower concentrations, the combinatorial treatment may be preserving myelin structure, and that systemic and local delivery are comparable at improving outcomes following neurotrauma.

scholarly journals ERG changes in albino and pigmented mice after optic nerve transection

2010 ◽  
Vol 50 (21) ◽  
pp. 2176-2187 ◽  
Author(s):  
Luis Alarcón-Martínez ◽  
Marcelino Avilés-Trigueros ◽  
Caridad Galindo-Romero ◽  
Javier Valiente-Soriano ◽  
Marta Agudo-Barriuso ◽  
...  
Keyword(s):  
Optic Nerve ◽  
Nerve Transection ◽  
Optic Nerve Transection

Unilateral optic nerve transection alters light response of suprachiasmatic nucleus and intergeniculate leaflet

2002 ◽  
Vol 282 (2) ◽  
pp. R569-R577 ◽  
Author(s):  
I-Hsiung Tang ◽  
Dean M. Murakami ◽  
Charles A. Fuller
Keyword(s):  
Optic Nerve ◽  
Neuropeptide Y ◽  
Suprachiasmatic Nucleus ◽  
Light Response ◽  
Inhibitory Effect ◽  
Nerve Transection ◽  
Fos Expression ◽  
Optic Nerve Transection ◽  
Intergeniculate Leaflet ◽  
Photic Input

The suprachiasmatic nucleus (SCN), the circadian pacemaker, receives photic input directly from the retina to synchronize the pacemaker to the environment. Additionally, the intergeniculate leaflet (IGL), which innervates the SCN, is known to modulate the retinal photic input to the SCN. To further understand the role of the IGL in mediating the photic input to the SCN, this study examined the effects of unilateral optic nerve transection (UONx) on the photic response of the SCN and IGL in adult and neonatal hamsters. UONx led to an overall reduction in light-induced c-Fos expression in the SCN and IGL. The c-Fos expression was greater in the SCN ipsilateral to the remaining eye, despite a symmetrically bilateral retinohypothalamic tract projection as revealed by intraocular injection of horseradish peroxidase. In contrast, UONx led to a greater c-Fos expression in the contralateral IGL. The contralateral IGL of UONx animals also revealed more neuropeptide Y-immunoreactive neurons, while the ipsilateral SCN of these animals exhibited a denser neuropeptide Y terminal field. The neonates with UONx showed a similar pattern with a slight compensation of the photic-induced c-Fos in the SCN. This study suggests that the IGL may have an ipsilateral inhibitory effect in mediating retinal photic input to the SCN.

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