Serum blocking factor as an index of metastatic spread following primary tumour excision

1975 ◽  
Vol 11 (12) ◽  
pp. 855-860 ◽  
Author(s):  
A.E. Bray ◽  
P.G. Holt
Keyword(s):  
Primary Tumour ◽  
Metastatic Spread ◽  
Blocking Factor ◽  
Serum Blocking Factor

Responsiveness of lymphocytes to soluble extracts of prostatic tumors and abrogation by serum-blocking factor(s)

Urology ◽  
1977 ◽  
Vol 9 (3) ◽  
pp. 314-316 ◽  
Author(s):  
Rashid A. Bhatti ◽  
Patrick D. Guinan ◽  
Charles F. McKiel ◽  
Irving M. Bush ◽  
Gailon R. Bruns ◽  
...  
Keyword(s):  
Blocking Factor ◽  
Serum Blocking Factor

The effect of the Progesterone-Induced Blocking Factor (PIBF) on E-cadherin expression, cell motility and invasion of primary tumour cell lines

2018 ◽  
Vol 125 ◽  
pp. 8-15 ◽  
Author(s):  
Tímea Balassa ◽  
Gergely Berta ◽  
László Jakab ◽  
Noémi Bohonyi ◽  
Júlia Szekeres-Bartho
Keyword(s):  
Cell Motility ◽  
Cell Lines ◽  
Tumour Cell ◽  
Primary Tumour ◽  
Blocking Factor ◽  
Tumour Cell Lines ◽  
E Cadherin

scholarly journals LAP1 regulates nuclear plasticity to enable constrained migration

2021 ◽  
Author(s):  
Yaiza Jung Garcia ◽  
Oscar Maiques ◽  
Irene Rodriguez-Hernandez ◽  
Bruce Fanshawe ◽  
Marie-Charlotte Domart ◽  
...  
Keyword(s):  
Cancer Cells ◽  
Primary Tumour ◽  
Leading Edge ◽  
Metastatic Potential ◽  
Metastatic Spread ◽  
Physical Constraints ◽  
Nuclear Lamins ◽  
Metastatic Lesions ◽  
Inner Nuclear Membrane Protein ◽  
Physical Challenge

Metastatic spread involves the dissemination of cancer cells from a primary tumour and their colonisation of distal sites. During this process, cancer cells must negotiate multiple physical constraints imposed by the microenvironment and tissue structure, and the biophysical properties of the nucleus place a physical challenge on this form of migration. By analysing nuclear genes upregulated during the acquisition of metastatic potential, we discovered increased expression of the inner nuclear membrane protein LAP1 in metastatic cell lines and at the leading edge of human primary tumours and in metastatic lesions. Human cells express two LAP1 isoforms (LAP1B and LAP1C), which differ in their amino terminus. We found that the longer isoform, LAP1B, binds more strongly to nuclear lamins and enhances nuclear mechanocoupling, whilst the shorter isoform, LAP1C, favours nuclear envelope blebbing and permits migration through physical constraints. Thus, we propose that LAP1B and LAP1C act together to support a permissive nucleus which overcomes the physical constraints that cancer cells face during metastatic spread.

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