Diazepam inhibits the spreading of chick embryo fibroblasts

1983 ◽  
Vol 143 (1) ◽  
pp. 153-162 ◽  
Author(s):  
R NAGELE ◽  
J PIETROLUNGO ◽  
M KOSCIUK ◽  
H LEE ◽  
F ROISEN
1978 ◽  
Vol 253 (16) ◽  
pp. 5869-5874
Author(s):  
B.H. Howard ◽  
S.L. Adams ◽  
M.E. Sobel ◽  
I. Pastan ◽  
B. de Crombrugghe

1976 ◽  
Vol 65 (2) ◽  
pp. 423-430 ◽  
Author(s):  
Lorraine LEBLOND-LAROUCHE ◽  
Claire DUPUIS ◽  
Rejean MORAIS

1981 ◽  
Vol 107 (2) ◽  
pp. 295-302 ◽  
Author(s):  
Mary H. Miller ◽  
Harold Amos ◽  
Donald A. Sens

1975 ◽  
Vol 18 (3) ◽  
pp. 441-451
Author(s):  
F. De Paermentier ◽  
R. Bassleer ◽  
A. Lepoint ◽  
C. Desaive ◽  
G. Goessens ◽  
...  

Chick embryo fibroblasts cultivated in vitro and Ehrlich ascites tumor cells (in vivo or in vitro) have been treated with amphotericin B. Cell multiplication is strongly inhibited. Large clear zones appear in the fibroblast nucleoi (phase-contrast and electron-microscope observations). Many treated fibroblasts and tumour cells have a high DNA content (pre-mitotic or polyploid level; measurements by cytophotometry). However, the RNA content (cytophotometry) and the total protein content (cytophotometry and micro-interferometry) are relatively low in the tumour cells. As shown by autoradiography, DNA synthesis is active but RNA synthesis and, in some cases, protein synthesis are inhibited. Due to this unbalanced growth, the cells cannot divide.


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