Lipid-lowering activity of atorvastatin and lovastatin in rodent species: triglyceride-lowering in rats correlates with efficacy in LDL animal models

: Berberine, as a representative isoquinoline alkaloid, exhibits significant hypolipidemic activity in both animal models and clinical trials. Recently, a large number of studies on the lipid-lowering mechanism of berberine and studies for improving its hypolipidemic activity have been reported, but for the most part, they have been either incomplete or not comprehensive. In addition, there have been a few specific reviews on the lipid-reducing effect of berberine. In this paper, the physicochemical properties, the lipid-lowering mechanism, and studies of the modification of berberine all are discussed to promote the development of berberine as a lipid-lowering agent. Subsequently, this paper provides some insights into the deficiencies of berberine in the study of lipid-lowering drug, and based on the situation, some proposals are put forward.

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Evaluation of Glucose and Lipid Lowering Activity of Arganimide A in Normal and Streptozotocin-Induced Diabetic Rats

Endocrine Metabolic & Immune Disorders - Drug Targets ◽

10.2174/1871530318666181113124727 ◽

2019 ◽

Vol 19 (4) ◽

pp. 503-510 ◽

Cited By ~ 2

Author(s):

Mohamed Eddouks ◽

Farid Khallouki ◽

Robert W. Owen ◽

Morad Hebi ◽

Remy Burcelin

Keyword(s):

Body Weight ◽

Blood Glucose ◽

Oral Administration ◽

Lipid Profile ◽

Plasma Cholesterol ◽

Diabetic Rats ◽

Lipid Lowering ◽

Glucose Levels ◽

Blood Glucose Levels ◽

Lowering Activity

Aims: Arganimide A (4,4-dihydroxy-3,3-imino-di-benzoic acid) is a compound belonging to a family of aminophenolics found in fruit of Argania spinosa. The purpose of this study was to investigate the glucose and lipid lowering activity of Arganimide A (ARG A). Methods: The effect of a single dose and daily oral administration of Arganimide A (ARG A) on blood glucose levels and plasma lipid profile was tested in normal and streptozotocin (STZ) diabetic rats at a dose of 2 mg/kg body weight. Results: Single oral administration of ARG A reduced blood glucose levels from 26.50±0.61 mmol/L to 14.27±0.73 mmol/L (p<0.0001) six hours after administration in STZ diabetic rats. Furthermore, blood glucose levels were decreased from 5.35±0.30 mmol/L to 3.57±0.17 mmol/L (p<0.0001) and from 26.50±0.61 mmol/L to 3.67±0.29 mmol/L (p<0.0001) in normal and STZ diabetic rats, respectively, after seven days of treatment. Moreover, no significant changes in body weight in normal and STZ rats were shown. According to the lipid profile, the plasma triglycerides levels were decreased significantly in diabetic rats after seven days of ARG treatment (p<0.05). Moreover, seven days of ARG A treatment decreased significantly the plasma cholesterol concentrations (p<0.001). Conclusion: ARG A possesses glucose and lipid-lowering activity in diabetic rats and this natural compound may be beneficial in the treatment of diabetes.

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Lipid lowering activity of Eclipta prostrata in experimental hyperlipidemia

Journal of Ethnopharmacology ◽

10.1016/j.jep.2005.10.031 ◽

2006 ◽

Vol 105 (3) ◽

pp. 332-335 ◽

Cited By ~ 63

Author(s):

C. Santhosh Kumari ◽

S. Govindasamy ◽

E. Sukumar

Keyword(s):

Lipid Lowering ◽

Eclipta Prostrata ◽

Experimental Hyperlipidemia ◽

Lowering Activity

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Structure characterization and lipid-lowering activity of a homogeneous heteropolysaccharide from sweet tea (Rubus Suavissmus S. Lee)

Carbohydrate Polymers ◽

10.1016/j.carbpol.2021.118757 ◽

2021 ◽

pp. 118757

Author(s):

Mengyao Liu ◽

Shan Shan ◽

Xin Gao ◽

Deyong Zeng ◽

Weihong Lu

Keyword(s):

Structure Characterization ◽

Lipid Lowering ◽

Lowering Activity

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Design of a pharmaceutical composition with a low-dose statin and a high lipid-lowering activity

Farmaciya (Pharmacy) ◽

10.29296/25419218-2021-01-09 ◽

2021 ◽

Vol 70 (1) ◽

pp. 52-56

Author(s):

Natalia Dmitrievna Bunyatyan ◽

Anastasia Evgen'evna Kozlova ◽

Vladimir Pavlovich Balashov ◽

Alexey Vladimirovich Balashov ◽

Ruslan Evgenievich Kazakov ◽

...

Keyword(s):

Low Dose ◽

Lipid Lowering ◽

High Lipid ◽

Pharmaceutical Composition ◽

Lowering Activity

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Elucidating the Beneficial Role of PPAR Agonists in Cardiac Diseases

International Journal of Molecular Sciences ◽

10.3390/ijms19113464 ◽

2018 ◽

Vol 19 (11) ◽

pp. 3464 ◽

Cited By ~ 13

Author(s):

Zaza Khuchua ◽

Aleksandr I. Glukhov ◽

Arnold W. Strauss ◽

Sabzali Javadov

Keyword(s):

Animal Models ◽

Hormone Receptors ◽

Lipid Lowering ◽

Acid Oxidation ◽

Peroxisome Proliferator ◽

Pharmacological Agents ◽

Beneficial Effects ◽

Ppar Agonists ◽

Energy Deprivation

Peroxisome proliferator-activated receptors (PPARs) are nuclear hormone receptors that bind to DNA and regulate transcription of genes involved in lipid and glucose metabolism. A growing number of studies provide strong evidence that PPARs are the promising pharmacological targets for therapeutic intervention in various diseases including cardiovascular disorders caused by compromised energy metabolism. PPAR agonists have been widely used for decades as lipid-lowering and anti-inflammatory drugs. Existing studies are mainly focused on the anti-atherosclerotic effects of PPAR agonists; however, their role in the maintenance of cellular bioenergetics remains unclear. Recent studies on animal models and patients suggest that PPAR agonists can normalize lipid metabolism by stimulating fatty acid oxidation. These studies indicate the importance of elucidation of PPAR agonists as potential pharmacological agents for protection of the heart from energy deprivation. Here, we summarize and provide a comprehensive analysis of previous studies on the role of PPARs in the heart under normal and pathological conditions. In addition, the review discusses the PPARs as a therapeutic target and the beneficial effects of PPAR agonists, particularly bezafibrate, to attenuate cardiomyopathy and heart failure in patients and animal models.

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Lipid Lowering Activity and Free Radical Scavenging Effect of Cinnamomum tamala (Fam: Lauraceae)

International Journal of Natural Sciences ◽

10.3329/ijns.v1i4.9735 ◽

1970 ◽

Vol 1 (4) ◽

pp. 93-96

Author(s):

R Al-Mamun ◽

A Hamid ◽

MK Islam ◽

JA Chowdhury ◽

ATM Zafrul Azam

Keyword(s):

Free Radical ◽

Lipid Profile ◽

Total Cholesterol ◽

Radical Scavenging Activity ◽

Radical Scavenging ◽

Antioxidant Property ◽

Free Radical Scavenging ◽

Lipid Lowering ◽

Increased Risk ◽

Lowering Activity

Lipid profile is a blood test that measures the amount of lipids, or fats, in your blood. The lipids measured are usually total cholesterol, HDL-C, LDL-C and triglycerides. When levels of these lipids are abnormal, there is an increased risk of heart attack and stroke. In our study, we use methanol crude extract for lipid lowering activity on rabbit and found that lipid profile was reduced by 14.0, 1.0, 4.0 and 15.0 mg/dl for total cholesterol, HDL-C, LDL-C and triglyceride respectively after using the plant extract (dose 500mg/rabbit for 10 days); where atorvastatin (0.005mg/rabbit) was used as standard lipid lowering agent. We also focused on the antioxidant property of crude methanol extract. Here we also carried out free radical-scavenging activity study and found the IC50 value for C. tamala is 6.00 μg/ml where the standard antioxidant (ascorbic acid) gave the value of 3.21μg/ml. DOI: http://dx.doi.org/10.3329/ijns.v1i4.9735 IJNS 2011 1(4): 93-96

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Antiartherosclerotic Effects of Plant Flavonoids

BioMed Research International ◽

10.1155/2014/480258 ◽

2014 ◽

Vol 2014 ◽

pp. 1-11 ◽

Cited By ~ 80

Author(s):

Shamala Salvamani ◽

Baskaran Gunasekaran ◽

Noor Azmi Shaharuddin ◽

Siti Aqlima Ahmad ◽

Mohd Yunus Shukor

Keyword(s):

Cardiovascular Diseases ◽

Side Effects ◽

Animal Models ◽

Vascular Diseases ◽

Lipid Lowering ◽

Peripheral Vascular ◽

Heart Attacks ◽

Synthetic Drug

Atherosclerosis is the process of hardening and narrowing the arteries. Atherosclerosis is generally associated with cardiovascular diseases such as strokes, heart attacks, and peripheral vascular diseases. Since the usage of the synthetic drug, statins, leads to various side effects, the plants flavonoids with antiartherosclerotic activity gained much attention and were proven to reduce the risk of atherosclerosisin vitroandin vivobased on different animal models. The flavonoids compounds also exhibit lipid lowering effects and anti-inflammatory and antiatherogenic properties. The future development of flavonoids-based drugs is believed to provide significant effects on atherosclerosis and its related diseases. This paper discusses the antiatherosclerotic effects of selected plant flavonoids such as quercetin, kaempferol, myricetin, rutin, naringenin, catechin, fisetin, and gossypetin.

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