Antigenic cross-reactivity between Necator americanus and Ascaris lumbricoides in a community in Papua New Guinea infected predominantly with hookworm

Author(s):  
D.I. Pritchard ◽  
R.J. Quinnell ◽  
P.G. McKean ◽  
L. Walsh ◽  
K.V. Leggett ◽  
...  
Parasitology ◽  
1993 ◽  
Vol 106 (4) ◽  
pp. 379-385 ◽  
Author(s):  
R. J. Quinnell ◽  
A. F. G. Slater ◽  
P. Tighe ◽  
E. A. Walsh ◽  
A. E. Keymer ◽  
...  

SUMMARYReinfection with hookworm (Necator americanus) following chemotherapy was studied over 2 years in a rural village in Madang Province, Papua New Guinea. The prevalence of hookworm infection had returned to pre-treatment levels after 2 years, and the geometric mean hookworm burden had returned to 58 % of the pre-treatment value. The rate of acquisition of adult worms was independent of host age, and was estimated as a geometric mean of 2·9–3·3 worms/host/year (arithmetic mean 7·9–8·9 worms/host/year). There was significant predisposition to hookworm infection; the strength of this predisposition did not vary significantly between age or sex classes.


Parasitology ◽  
1990 ◽  
Vol 100 (2) ◽  
pp. 317-326 ◽  
Author(s):  
D. I. Pritchard ◽  
R. J. Quinnell ◽  
A. F. G. Slater ◽  
P. G. McKean ◽  
D. D. S. Dale ◽  
...  

SUMMARYBaseline data from an immuno-epidemiological study of hookworm infection in a rural village in Madang Province, Papua New Guinea are reported. Necator americanus was found to be the commonest helminth infection, with a prevalence of near 100% and intensity of 40 worms per host in adults. Enterobius vermicularis, Ascaris lumbricoides and Trichuris trichiura were also present, at prevalences of 53, 10 and 3% respectively; Ancylostoma duodenale was absent. The frequency distribution of N. americanus was highly over-dispersed, and was well described by a negative binomial distribution with aggregation parameter, k, of 0·370. Intensity of infection was significantly related to host age, but did not differ between the sexes. Haemoglobin levels and haematocrit values were indicative of anaemia in the community, but were unrelated to hookworm infection. Levels of antibodies (IgG, IgA and 1gM combined) against adult Necator cuticular collagen and excretory-secretory (ES) products were determined.


Author(s):  
Donald Denoon ◽  
Kathleen Dugan ◽  
Leslie Marshall

1984 ◽  
Vol 29 (10) ◽  
pp. 786-788
Author(s):  
Patricia M. Greenfield

2012 ◽  
Author(s):  
Esteban Tristan ◽  
Mei-Chuan Kung ◽  
Peter Caccamo

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