Deep-vein thrombosis and the incidence of subsequent malignant disease

1993 ◽  
Vol 70 ◽  
pp. S39
Keyword(s):  
Deep Vein Thrombosis ◽  
Malignant Disease ◽  
Vein Thrombosis ◽  
Deep Vein

Abnormal Blood Yield Stress as an Aetiological Factor in Postoperative Deep Venous Thrombosis

1975 ◽  
Author(s):  
W. V. Humphreys ◽  
A. Walker ◽  
D. Charlesworth
Keyword(s):  
Deep Vein Thrombosis ◽  
Yield Stress ◽  
Malignant Disease ◽  
Aetiological Factor ◽  
Venous Stasis ◽  
Vein Thrombosis ◽  
High Incidence ◽  
Deep Vein ◽  
Postoperative Deep Venous Thrombosis ◽  
Low Shear

An elevated blood viscosity could lead to increased venous stasis and a higher incidence of post-operative deep vein thrombosis. Immediately preoperatively we have measured, using a Contraves low shear 2 viscometer, blood yield stress and viscosity at high and low shear rate in 28 general surgical patients. These patients were then screened by the standard I125 fibrinogen technique to detect the development of deep vein thrombosis post-operatively.13 patients developed a deep vein thrombosis. These patients had a significantly higher blood yield stress, corrected to a standard haemoerit of 45%, than the others (P < 0.01 students t). All other viscosity parameters were normal in these patients. Patients with malignant disease had a very high incidence of thrombosis (90%: 30%) and significantly higher yield stress values (mean 0.26 dynes/cm2: mean 0.194 dynes/cm2, P < 0.0005 students t) compared to patients with benign disease.We conclude that a high blood yield stress could be an important aetiological factor in thrombosis and the high values obtained in patients with malignant disease could partly explain the high incidence in these patients.

Deep-vein thrombosis and the incidence of subsequent malignant disease

1992 ◽  
Vol 65 ◽  
pp. S48
Author(s):  
P. Prandoni ◽  
A.W.A. Lensing ◽  
H.R. Büller ◽  
A. Cogo ◽  
S. Cuppini ◽  
...  
Keyword(s):  
Deep Vein Thrombosis ◽  
Malignant Disease ◽  
Vein Thrombosis ◽  
Deep Vein

scholarly journals ‘Hospice inpatient deep vein thrombosis detection (HIDDen) in advanced non-malignant diseases’: a longitudinal pilot study

2020 ◽  
pp. bmjspcare-2019-002039
Author(s):  
Clare White ◽  
Simon Noble ◽  
Flavia Swan ◽  
Max Watson ◽  
Victoria Allgar ◽  
...  
Keyword(s):  
Deep Vein Thrombosis ◽  
Venous Thromboembolism ◽  
Malignant Disease ◽  
Femoral Vein ◽  
Descriptive Analysis ◽  
Leg Pain ◽  
Cross Sectional ◽  
Vein Thrombosis ◽  
Deep Vein ◽  
Prospective Longitudinal

ObjectivesTo gain preliminary data regarding the prevalence of proximal deep vein thrombosis (DVT) in those with non-malignant conditions admitted to specialist palliative care units (SPCUs).MethodsData were collected as part of a prospective longitudinal observational study in five SPCUs in England, Wales and Northern Ireland (Registration: ISRCTN97567719) to estimate the prevalence of proximal femoral vein DVT in people admitted to SPCUs. The primary outcome for this exploratory substudy was the prevalence of DVT in patients with non-malignant palliative conditions. Consecutive consenting adults underwent bilateral femoral vein ultrasonography within 48 hours of admission. Data were collected on symptoms associated with venous thromboembolism. Patients were ineligible if the estimated prognosis was <5 days. Cross-sectional descriptive analysis was conducted on baseline data and prevalence estimates presented with 95% CIs.Results1390 patients were screened, 28 patients had non-malignant disease and all were recruited. The mean age 68·8 (SD 12·0), range 43–86 years; men 61%; survival mean 86 (SD 108.5) range 1–345 days. No patient had a history of venous thromboembolism. Four (14%) were receiving thromboprophylaxis. Of 22 evaluable scans, 8 (36%, 95% CI: 17% to 59%) showed femoral vein DVT. The level of reported relevant symptoms (leg oedema, leg pain, chest pain and breathlessness) was high irrespective of the presence of DVT.ConclusionsOur exploratory data indicate one in three people admitted to an SPCU with non-malignant disease had a femoral vein DVT. Although definitive conclusions cannot be drawn, these data justify a larger prospective survey.

PREDICTION OF POST-OPERATIVE DVT BY SALINE DILUTION

1987 ◽  
Author(s):  
D Chayen ◽  
S D Blair ◽  
C N McCollum ◽  
R M Greenhalgh
Keyword(s):  
Deep Vein Thrombosis ◽  
High Risk ◽  
Malignant Disease ◽  
Risk Group ◽  
High Risk Group ◽  
Clotting Time ◽  
Vein Thrombosis ◽  
The Mean ◽  
Deep Vein

Clinically, it is difficult to predict deep vein thrombosis (DVT), but the in vitro saline dilution test using the Thrombo-elastograph (TEG) is reported to identify the risk for individual patients [1]. The Biobridge Impedance Clotting Time (ICT) is more sensitive and reproducible than the TEG [2], and we therefore studied 33 patients undergoing elective laparotomy to see if pre-operative saline dilution tests using both the TEG and ICT predicted post-operative DVTs. Post-operatively, both legs were scanned daily for 7 days using 125I Fibrinogen to detect DVTs.The mean age of the patients was 65.7±2.4 years and 17 had malignant disease. In this clinically high risk group, 24 developed a DVT.Fifty-one percent were predicted correctly by TEG. The ICT was significantly better as a predictor with 79% of all patients correctly predicted (p<0.01).The saline dilution test using the ICT is a significant improvement on the TEG, and may enable us to tailor DVT prophylaxis policy to each patient’s specific requirements.Heather BP, Jennings SA, Greenhalgh RM. The saline dilution test - a preoperative predictor of DVT. Br J Surg 1980; 67: 63-65Blair SD, Menashi S, Samson D, Greenhalgh RM. Can the hypercoagulability of surgery be measured? Br J Surg 1986; 73: 500.

Feasibility Study of Catheter-directed Thrombolysis with Recombinant Staphylokinase in Deep Venous Thrombosis

1998 ◽  
Vol 79 (03) ◽  
pp. 517-519 ◽  
Author(s):  
Stephane Heymans ◽  
Raymond Verhaeghe ◽  
Luc Stockx ◽  
Désiré Collen
Keyword(s):  
Deep Vein Thrombosis ◽  
Continuous Infusion ◽  
High Speed ◽  
Minor Bleeding ◽  
Vein Thrombosis ◽  
Catheter Directed Thrombolysis ◽  
Long Term Follow Up ◽  
Valve Function ◽  
Rotating Impeller ◽  
Deep Vein

SummaryThe feasibility of catheter-directed thrombolysis with recombinant staphylokinase was evaluated in six selected patients with deep vein thrombosis. The patients underwent intrathrombus infusion of recombinant staphylokinase (2 mg bolus followed by a continuous infusion of 1 mg/h). Heparin was given via the catheter as a bolus (5000 U) and as a continuous infusion (1000 U/h). Complete lyis was obtained in five patients and partial lysis in one patient. Complications consisted of minor bleeding in four subjects. Symptomatic reocclusion occurred in one. Debulking of the thrombus mass by a high speed rotating impeller (n = 1) and stenting (n = 3) were used as additional interventions. An underlying anatomical abnormality was present in two patients. Long term follow up revealed normal patency in all patients and normal valve function in four patients. Symptomatic venous insufficiency with valve dysfunction was present in the two with a second thrombotic episode.Thus catheter-directed infusion of recombinant staphylokinase in patients with deep vein thrombosis appears feasible and may be associated with a high frequency of thrombolysis. Larger studies to define the clinical benefit of this treatment appear to be warranted.

Sign in / Sign up

Export Citation Format

Share Document