Presence of autoantibodies to peptidyl-prolyl cis-trans isomerase (cyclosporin A-binding protein) in systemic lupus erythematosus

1992 ◽  
Vol 63 (1) ◽  
pp. 58-65 ◽  
Author(s):  
Masayoshi Harigai ◽  
Masako Hara ◽  
Nobuhiro Takahashi ◽  
Atsushi Kitani ◽  
Tatsuo Hirose ◽  
...  
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Cyclosporin A ◽  
Lupus Erythematosus ◽  
Binding Protein ◽  
Systemic Lupus

scholarly journals Successful treatment of pure red cell aplasia associated with systemic lupus erythematosus with cyclosporin A

Rheumatology ◽  
2000 ◽  
Vol 39 (10) ◽  
pp. 1155-1157 ◽  
Author(s):  
C. Duarte‐Salazar ◽  
J. Cazarín‐Barrientos ◽  
M. V. Goycochea‐Robles ◽  
J. Collazo‐Jaloma ◽  
R. Burgos‐Vargas
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Cyclosporin A ◽  
Successful Treatment ◽  
Lupus Erythematosus ◽  
Pure Red Cell Aplasia ◽  
Red Cell ◽  
Systemic Lupus ◽  
Red Cell Aplasia

C4-Binding Protein in Sera of Patients with Systemic Lupus Erythematosus and Mixed Essential Cryoglobulinemia

Complement ◽  
1984 ◽  
Vol 1 (2) ◽  
pp. 81-86 ◽  
Author(s):  
J.A. Schifferli ◽  
Aysin Bakkaloglu ◽  
N. Amos ◽  
D.K. Peters
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Lupus Erythematosus ◽  
Binding Protein ◽  
Systemic Lupus

scholarly journals Effect of low-dose cyclosporin a on systemic lupus erythematosus disease activity

1994 ◽  
Vol 37 (4) ◽  
pp. 551-558 ◽  
Author(s):  
Michiaki Tokuda ◽  
Noriyuki Kurata ◽  
Akihito Mizoguchi ◽  
Masayuki Inoh ◽  
Kunio Seto ◽  
...  
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Disease Activity ◽  
Cyclosporin A ◽  
Lupus Erythematosus ◽  
Low Dose ◽  
Systemic Lupus Erythematosus Disease ◽  
Systemic Lupus

SerumWisteria floribundaagglutinin-positive Mac-2-binding protein can reflect systemic lupus erythematosus activity

Lupus ◽  
2017 ◽  
Vol 27 (5) ◽  
pp. 771-779 ◽  
Author(s):  
S S Ahn ◽  
Y Park ◽  
D D Lee ◽  
A L M Bothwell ◽  
S M Jung ◽  
...  
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Lupus Erythematosus ◽  
Binding Protein ◽  
Systemic Lupus ◽  
Systemic Lupus Erythematosus Activity

Developmental characterization of a Drosophila RNA-binding protein homologous to the human systemic lupus erythematosus-associated La/SS-B autoantigen

1994 ◽  
Vol 14 (8) ◽  
pp. 5123-5129
Author(s):  
C Bai ◽  
Z Li ◽  
P P Tolias
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Lupus Erythematosus ◽  
Rna Binding ◽  
Binding Protein ◽  
Rna Polymerase Iii ◽  
Rna Binding Protein ◽  
Cdna Clones ◽  
Systemic Lupus ◽  
General Role ◽  
Visceral Mesoderm

Patients with humoral autoimmune diseases such as systemic lupus erythematosus and Sjögren's syndrome contain antibodies in their sera directed against certain normal cellular components such as the La/SS-B autoantigen, an RNA-binding protein believed to function as a putative processor of RNA polymerase III precursor transcripts. We have identified cDNA clones from the fruit fly Drosophila melanogaster that encode a protein displaying significant sequence homology with human La/SS-B. The fly protein (which we refer to as D-La) contains a putative ribonucleoprotein 1 (RNP1) and RNP2 RNA-binding domain. D-La also possesses a leucine zipper motif, suggesting that it may interact with itself or other proteins. Using gel retardation analysis, we show that D-La can bind RNA; in addition, we demonstrate the first reported DNA-binding activity associated with a La protein. Northern (RNA) blot analysis revealed a single 1,600-nucleotide transcript expressed throughout embryonic, larval, pupal, and adult development. Surprisingly, whole-mount in situ hybridization experiments revealed that D-La transcripts are not present in all ovarian tissues. In addition, early expression throughout the embryo is followed by a restricted pattern of mesodermal expression that is later confined to the visceral mesoderm, gonads, gut, and salivary glands. These results suggest that D-La may play a more specialized role during fly development as opposed to a rather general role inferred by its homology to La proteins from other organisms.

scholarly journals Interaction between anti-DNA and anti-DNA-binding protein autoantibodies in cryoglobulins from sera of patients with systemic lupus erythematosus.

1986 ◽  
Vol 164 (4) ◽  
pp. 1029-1042 ◽  
Author(s):  
W H Reeves ◽  
N Chiorazzi
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Dna Binding ◽  
Lupus Erythematosus ◽  
Immune Complexes ◽  
Protein Complex ◽  
Binding Protein ◽  
Dna Binding Protein ◽  
Systemic Lupus ◽  
Variable Regions ◽  
Dna Antibodies

We have previously shown that sera from some patients with SLE and related disorders contain autoantibodies to a DNA-binding protein complex designated p70/p80. The present study shows that anti-p70/p80 autoantibodies are frequently accompanied by anti-DNA antibodies and cryoglobulins. When the cryoglobulins were isolated, they were found to be specifically enriched in both anti-p70/p80 and anti-DNA activities. The anti-p70/p80 and anti-DNA antibodies were found to be distinct populations of autoantibodies rather than a single crossreactive species, since they could be separated from one another by chromatography on DNA-cellulose. Certain human anti-DNA mAbs could inhibit the binding of autoimmune polyclonal anti-p70/p80 antibodies to p70/p80, suggesting that anti-DNA antibodies might also associate with the variable regions of some anti-p70/p80 antibodies in the cryoglobulins. Binding of one murine anti-p70/p80 mAb (111-12) also was inhibited by certain human anti-DNA mAbs, but the binding of another murine mAb (162-11) to a different epitope of p70/p80 was not. These studies suggest that certain anti-DNA antibodies may interact with the variable regions of a population of anti-p70/p80 antibodies. The cryoglobulins found in the sera containing both anti-p70/p80 and anti-DNA antibodies may represent immune complexes consisting, in part, of idiotype and antiidiotype.

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