The flower pot technique of Rapid Eye Movement (REM) sleep deprivation

1974 ◽  
Vol 2 (4) ◽  
pp. 553-556 ◽  
Author(s):  
Wallace B. Mendelson ◽  
Robert D. Guthrie ◽  
Ghislaine Frederick ◽  
Richard Jed Wyatt
Keyword(s):  
Sleep Deprivation ◽  
Eye Movement ◽  
Rem Sleep ◽  
Rapid Eye Movement ◽  
Rem Sleep Deprivation ◽  
Pot Technique

Noradrenergic activity in rat brain during rapid eye movement sleep deprivation and rebound sleep

1995 ◽  
Vol 268 (6) ◽  
pp. R1456-R1463 ◽  
Author(s):  
T. Porkka-Heiskanen ◽  
S. E. Smith ◽  
T. Taira ◽  
J. H. Urban ◽  
J. E. Levine ◽  
...  
Keyword(s):  
Sleep Deprivation ◽  
Eye Movement ◽  
Rem Sleep ◽  
High Performance ◽  
Locus Ceruleus ◽  
Rapid Eye Movement ◽  
Rem Sleep Deprivation ◽  
Large Platform ◽  
Male Wistar Rats ◽  
Th Mrna

Noradrenergic locus ceruleus neurons are most active during waking and least active during rapid eye movement (REM) sleep. We expected REM sleep deprivation (REMSD) to increase norepinephrine utilization and activate the tyrosine hydroxylase (TH) gene critical for norepinephrine production. Male Wistar rats were deprived of REM sleep with the platform method. Rats were decapitated after 8, 24, or 72 h on small (REMSD) or large (control) platforms or after 8 or 24 h of rebound sleep after 72 h of the platform treatment. During the first 24 h, norepinephrine concentration, measured by high-performance liquid chromatography/electrochemical detection, was lower in the neocortex, hippocampus, and posterior hypothalamus in REMSD rats than in large-platform controls. After 72 h of REMSD, TH mRNA, measured by in situ hybridization, was increased in the locus ceruleus and norepinephrine concentrations were increased. Polygraphy showed that small-platform treatment caused effective and selective REMSD. Serum corticosterone measurement by radioimmunoassay indicated that the differences found in norepinephrine and TH mRNA were not due to differences in stress between the treatments. The novel finding of sleep deprivation-specific increase in TH gene expression indicates an important mechanism of adjusting to sleep deprivation.

Effects of rapid eye movement (REM) sleep deprivation on pain sensitivity in the rat

2001 ◽  
Vol 900 (2) ◽  
pp. 261-267 ◽  
Author(s):  
S Hakki Onen ◽  
Abdelkrim Alloui ◽  
Didier Jourdan ◽  
Alain Eschalier ◽  
Claude Dubray
Keyword(s):  
Sleep Deprivation ◽  
Eye Movement ◽  
Rem Sleep ◽  
Pain Sensitivity ◽  
Rapid Eye Movement ◽  
Rem Sleep Deprivation

Homeostasis of REM Sleep After Total and Selective Sleep Deprivation in the Rat

2000 ◽  
Vol 84 (5) ◽  
pp. 2699-2702 ◽  
Author(s):  
Adrián Ocampo-Garcés ◽  
Enrique Molina ◽  
Alberto Rodríguez ◽  
Ennio A. Vivaldi
Keyword(s):  
Sleep Deprivation ◽  
Eye Movement ◽  
Rem Sleep ◽  
Rapid Eye Movement ◽  
Homeostatic Regulation ◽  
Rem Sleep Deprivation ◽  
Total Sleep Deprivation ◽  
Final Value ◽  
Median Amount

During specific rapid eye movement (REM) sleep deprivation its homeostatic regulation is expressed by progressively more frequent attempts to enter REM and by a compensatory rebound after the deprivation ends. The buildup of pressure to enter REM may be hypothesized to depend just on the time elapsed without REM or to be differentially related to non-REM (NREM) and wakefulness. This problem bears direct implications on the issue of the function of REM and its relation to NREM. We compared three protocols that combined REM-specific and total sleep deprivation so that animals underwent similar 3-h REM deprivations but different concomitant NREM deprivations for the first 2 (2T1R), 1 (1T2R), or 0 (3R) hours. Deprivation periods started at hour 6 after lights on. Twenty-two chronically implanted rats were recorded. The median amount of REM during all three protocols was ∼1 min. The deficits of median amount of NREM in minutes within the 3-h deprivation periods as compared with their baselines were, respectively for 2T1R, 1T2R, and 3R, 35 (43%), 25 (25%), and 7 (7%). Medians of REM rebound in the three succeeding hours, in minutes above baseline, were, respectively, 8 (44%), 9 (53%), and 9 (50%), showing no significant differences among protocols. Attempted transitions to REM showed a rising trend during REM deprivations reaching a final value that did not differ significantly among the three protocols. These results support the hypothesis that the build up of REM pressure and its subsequent rebound is primarily related to REM absence independent of the presence of NREM.

Effects of rapid eye movement (REM) sleep deprivation on shock-induced fighting☆☆☆

1968 ◽  
Vol 3 (3) ◽  
pp. 425-432 ◽  
Author(s):  
B MORDEN ◽  
R CONNER ◽  
G MITCHELL ◽  
W DEMENT ◽  
S LEVINE
Keyword(s):  
Sleep Deprivation ◽  
Eye Movement ◽  
Rem Sleep ◽  
Rapid Eye Movement ◽  
Rem Sleep Deprivation

Marijuana and Ethanol: Effects on Sleep

1973 ◽  
Vol 4 (2) ◽  
pp. 201-212 ◽  
Author(s):  
Vincent P. Zarcone
Keyword(s):  
Sleep Deprivation ◽  
Eye Movement ◽  
Neuronal Activity ◽  
Slow Wave ◽  
Rem Sleep ◽  
Slow Wave Sleep ◽  
Rapid Eye Movement ◽  
Acute Effects ◽  
Rem Sleep Deprivation ◽  
The Public

Both marijuana and alcohol have effects on sleep which can be clinically important if either drug is used heavily. A number of polygraphic studies of both drugs' effect on sleep demonstrate that both are rapid eye movement (REM) sleep suppressors and that both effect the REM sleep deprivation response for days after the acute effects have ceased. Marijuana also increases slow wave sleep compared to alcohol which decreases it. The studies reviewed indicate that marijuana, like alcohol, has persisting effects on neuronal activity and presumably on its underlying neurochemical regulation. Also, the studies suggest that caution should be employed in advising the public about the use of marijuana.

Rapid eye movement (REM) sleep deprivation, stress and intermediary metabolism

1974 ◽  
Vol 22 (6) ◽  
pp. 1157-1159 ◽  
Author(s):  
W. Mendelson ◽  
R. D. Guthrie ◽  
R. Guynn ◽  
R. L. Harris ◽  
R. J. Wyatt
Keyword(s):  
Sleep Deprivation ◽  
Eye Movement ◽  
Rem Sleep ◽  
Intermediary Metabolism ◽  
Rapid Eye Movement ◽  
Rem Sleep Deprivation
Sign in / Sign up

Export Citation Format

Share Document