High constitutive expression of heat shock protein 90α in human acute leukemia cells

1992 ◽  
Vol 16 (6-7) ◽  
pp. 597-605 ◽  
Author(s):  
Yuji Yufu ◽  
Junji Nishimura ◽  
Hajime Nawata
Keyword(s):  
Heat Shock ◽  
Heat Shock Protein ◽  
Acute Leukemia ◽  
Constitutive Expression ◽  
Leukemia Cells

High expression of heat shock protein 90 alpha and its significance in human acute leukemia cells

Gene ◽  
2014 ◽  
Vol 542 (2) ◽  
pp. 122-128 ◽  
Author(s):  
Wen-Liang Tian ◽  
Fei He ◽  
Xue Fu ◽  
Jun-Tang Lin ◽  
Ping Tang ◽  
...  
Keyword(s):  
Heat Shock ◽  
Heat Shock Protein ◽  
Acute Leukemia ◽  
Heat Shock Protein 90 ◽  
High Expression ◽  
Leukemia Cells

Study of heat shock protein HSP90α, HSP70, HSP27 mRNA expression in human acute leukemia cells

1996 ◽  
Vol 16 (4) ◽  
pp. 212-216 ◽  
Author(s):  
Xiao Kanyan ◽  
Liu Wenli ◽  
Qu Shen ◽  
Sun Hanying ◽  
Tang Jinzhi
Keyword(s):  
Heat Shock ◽  
Heat Shock Protein ◽  
Acute Leukemia ◽  
Mrna Expression ◽  
Leukemia Cells

scholarly journals Heat Shock Protein 90 Inhibition Depletes TrkA Levels and Signaling in Human Acute Leukemia Cells

2010 ◽  
Vol 9 (8) ◽  
pp. 2232-2242 ◽  
Author(s):  
Rekha Rao ◽  
Srilatha Nalluri ◽  
Warren Fiskus ◽  
Ramesh Balusu ◽  
Atul Joshi ◽  
...  
Keyword(s):  
Heat Shock ◽  
Heat Shock Protein ◽  
Acute Leukemia ◽  
Heat Shock Protein 90 ◽  
Leukemia Cells

scholarly journals Study of HSPB6: Insights into the Properties of the Multifunctional Protective Agent

2017 ◽  
Vol 44 (1) ◽  
pp. 314-332 ◽  
Author(s):  
Fazhao Li ◽  
Han Xiao ◽  
Fangfang Zhou ◽  
Zhiping Hu ◽  
Binbin Yang
Keyword(s):  
Heat Shock ◽  
Heat Shock Protein ◽  
Muscle Relaxation ◽  
Constitutive Expression ◽  
Small Heat Shock Protein ◽  
Protective Role ◽  
Smooth Muscle Relaxation ◽  
Protective Agent ◽  
Cellular Targets ◽  
The Central Nervous System

HSPB6(Heat shock protein B6), is also referred to as P20/HSP20. Unlike other many other members of sHSP(small Heat shock protein) family, which tend to form high-molecular-mass oligomers, in solution, human HSPB6 only forms dimers. However, it still exhibits chaperon-like activity comparable with that of HSPB5. It is expressed ubiquitously, with high and constitutive expression in muscular tissues. sHSPs characteristically function as molecular chaperones and HSPB6 also has a molecular chaperone activity. HSPB6 is up-regulated in response to diverse cellular stress or damage and protect cells from otherwise lethal conditions. HSPB6 is widely recognized as a principle mediator of cardioprotective signaling and recent studies have unraveled the protective role of HSPB6 in disease or injury to the central nervous system. Moreover, accumulating evidence has implicated HSPB6 as a key mediator of diverse vital physiological processes, such as smooth muscle relaxation, platelet aggregation. The versatility of HSPB6 can be explained by its direct involvement in regulating different client proteins and its ability to form heterooligomer with other sHSPs, which seems to be dependent on HSPB6 phosphorylation. This review focuses on the properties including expression and regulation pattern, phosphorylation, chaperon activity, multiple cellular targets of HSPB6, as well as its possible role in physical and pathological conditions.

Anti-proliferative activity of heat shock protein (Hsp) 90 inhibitors via β-catenin/TCF7L2 pathway in adult T cell leukemia cells

2009 ◽  
Vol 284 (1) ◽  
pp. 62-70 ◽  
Author(s):  
Ryosuke Kurashina ◽  
Junko H. Ohyashiki ◽  
Chiaki Kobayashi ◽  
Ryoko Hamamura ◽  
Yu Zhang ◽  
...  
Keyword(s):  
T Cell ◽  
Heat Shock ◽  
Heat Shock Protein ◽  
Proliferative Activity ◽  
Leukemia Cells ◽  
T Cell Leukemia ◽  
Cell Leukemia ◽  
Adult T Cell Leukemia ◽  
Hsp 90

scholarly journals Resveratrol induces apoptosis in K562 (chronic myelogenous leukemia) cells by targeting a key survival protein, heat shock protein 70

2008 ◽  
Vol 99 (6) ◽  
pp. 1109-1116 ◽  
Author(s):  
Prabir K. Chakraborty ◽  
Soumyajit Banerjee Mustafi ◽  
Sudipto Ganguly ◽  
Mitali Chatterjee ◽  
Sanghamitra Raha
Keyword(s):  
Heat Shock ◽  
Heat Shock Protein ◽  
Chronic Myelogenous Leukemia ◽  
Heat Shock Protein 70 ◽  
Myelogenous Leukemia ◽  
Leukemia Cells ◽  
Chronic Myelogenous Leukemia Cells
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