Time-dependent effect of theophylline on methyl-cholanthrene-induced DNA repair in human mitogen-stimulated lymphocytes

1985 ◽  
Vol 147 (5) ◽  
pp. 313
Author(s):  
A.L. Pawlak ◽  
K. Szyfter ◽  
K.E. Wiktorowicz
Keyword(s):  
Dna Repair ◽  
Time Dependent ◽  
Dependent Effect ◽  
Time Dependent Effect

Time-dependent effect of an oral hypoglycemic agent upon serum glucose levels

1973 ◽  
Vol 10 (4) ◽  
pp. 841-851
Author(s):  
Juan J. Gagliardino ◽  
María T. Pessacq ◽  
Oscar Marcote ◽  
Elma E. Gagliardino
Keyword(s):  
Serum Glucose ◽  
Time Dependent ◽  
Oral Hypoglycemic Agent ◽  
Dependent Effect ◽  
Glucose Levels ◽  
Hypoglycemic Agent ◽  
Time Dependent Effect

A Risk-Adapted Strategy of Adjuvant Paclitaxel/Carboplatin in Early-Stage Ovarian Cancer: Time-Dependent Effect of 4 versus 6 Cycles on Outcome

Oncology ◽  
2011 ◽  
Vol 81 (5-6) ◽  
pp. 365-371 ◽  
Author(s):  
Aristotle Bamias ◽  
Christina Bamia ◽  
Alexandra Karadimou ◽  
Nikolaos Soupos ◽  
Flora Zagouri ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Early Stage ◽  
Time Dependent ◽  
Dependent Effect ◽  
Time Dependent Effect ◽  
Early Stage Ovarian Cancer

scholarly journals Evaluation of spermicidal activity of saponosides from Saponaria officinalis / Caryophyllaceae, Glycyrrhizia glabra / Fabaceae and Herniaria glabra / Caryophyllaceae

2021 ◽  
Author(s):  
Mohamed Réda Sefrioui ◽  
Ibrahim Sbai El Othmani ◽  
Halima Filali ◽  
Sanae Derfoufi ◽  
Soufiane Derraji ◽  
...  
Keyword(s):  
Natural Products ◽  
Side Effects ◽  
Time Dependent ◽  
Time Intervals ◽  
Dependent Effect ◽  
Time Dependent Effect ◽  
Sperm Mobility ◽  
In Vitro Effects ◽  
Saponaria Officinalis

Background and objective. Chemical spermicides currently marketed and widely used are known to have many side effects. Thereby, and in order to look for more tolerated natural spermicidal agents, the aim of this work was to evaluate the spermicidal potential of saponin extracts from the roots of Saponaria officinalis / Caryophyllaceae, Glycyrrhizia glabra / Fabaceae, and Herniaria glabra / Caryophyllaceae by studying their in vitro effects on sperm mobility and vitality. Methods. Methanolic saponin extracts from the plants roots were performed. Sperm suspensions were prepared by centrifugation on a PureSperm® density gradient (70 and 45%) and incubated with various concentrations of saponin extracts (50, 250, 500 and 750 mg/mL) at 37°C. The spermicidal activity was evaluated by studying the mobility and vitality of spermatozoa at different time intervals ranging from 10 to 240 minutes. Results. A dose and time dependent effect on sperm mobility and vitality was observed for our extracts. Extracts from Saponaria officinalis roots induced an irreversible immobilization and a total non-viability of sperm within 10 minutes at a concentration of 750 mg/mL. A similar effect was observed within 30 minutes at 750 mg/mL for Herniaria glabra extract and within 90 minutes at 500 mg/ml for Glycyrrhizia glabra extract. Conclusion. The results of our study showed that the saponin extracts of our plants roots possess potent in vitro dose and time dependant spermicidal effect. These natural products could therefore represent a safer and better tolerated alternative to chemical spermicides.

The Time-Dependent Effect of Corrosion of Steel Strands on Prestressed Concrete Beam Bridges

2014 ◽  
Vol 638-640 ◽  
pp. 1038-1044
Author(s):  
Peng Wang ◽  
Li Zhang ◽  
Fu Min Wang ◽  
Zan Peng Zhang ◽  
Yun He
Keyword(s):  
Prestressed Concrete ◽  
Limit State ◽  
Time Dependent ◽  
Dependent Effect ◽  
Steel Strand ◽  
Flexural Bearing Capacity ◽  
Time Dependent Effect ◽  
Dependent Model ◽  
Time Dependent Model ◽  
Degradation Time

Based on the concrete carbonization theory, we analyze the time when prestressed steel strands begin to corrode, and put forward the degradation time-dependent model for cross-sectional area of a corroding steel strand; with the comparison of existing research results, we propose the degradation time-dependent model for mechanical properties of corroded steel strands, including the nominal ultimate strength and nominal elastic modulus. We deduce a time-dependent model for the prestressing loss due to steel strand corrosion. Taking a prestressed concrete hollow slab bridge as an example, we analyze the time-dependent effect of the corroded strands on the concrete stress at serviceability limit state and flexural bearing capacity at ultimate limit state. Research shows that the bottom edge stress and flexural bearing capacity at mid-span of the beams will reduce sharply if the prestressed strands corrode, even corrosion can damage the safety of bridge in just a few years. These results can be for information of further experiments and researches.

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