Immune modulation within the brain: recruitment of inflammatory cells and increased major histocompatibility antigen expression following intracerebral injection of interferon-γ

1991 ◽  
Vol 34 (2-3) ◽  
pp. 121-132 ◽  
Author(s):  
Michael P. Sethna ◽  
Lois A. Lampson
Keyword(s):  
Immune Modulation ◽  
Antigen Expression ◽  
Inflammatory Cells ◽  
Interferon Γ ◽  
Histocompatibility Antigen ◽  
Intracerebral Injection ◽  
Major Histocompatibility ◽  
Major Histocompatibility Antigen ◽  
The Brain

Differential expression of porcine major histocompatibility DNA sequences introduced into mouse L cells

1983 ◽  
Vol 3 (11) ◽  
pp. 2006-2016
Author(s):  
M L Satz ◽  
D S Singer
Keyword(s):  
Dna Sequences ◽  
Genomic Dna ◽  
Histocompatibility Antigen ◽  
Transformed Cells ◽  
Major Histocompatibility ◽  
Major Histocompatibility Antigen ◽  
L Cells ◽  
Foreign Dna ◽  
Differential Transcription ◽  
Major Histocompatibility Gene

The expression of a porcine genomic DNA segment containing a major histocompatibility gene and its chromatin structure in mouse L cells have been investigated. The transformed cells, which contain about two copies of the 17.8-kilobase pig DNA insert per haploid genome, stably and uniformly express major histocompatibility antigen on their surfaces. This expression is the result of differential transcription of the 3-kilobase major histocompatibility gene; the other 14 kilobases of pig sequences flanking the coding sequence are not transcribed. Although the entire pig DNA segment is packaged into nucleosomes, only the transcriptionally active DNA sequences are packaged in a DNase I-sensitive conformation. These results suggest that the expression of this foreign DNA is actively regulated in L cells.

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