Formulation of oral mucosal drug delivery systems for the systemic delivery of bioactive materials

1994 ◽  
Vol 13 (1-2) ◽  
pp. 75-87 ◽  
Author(s):  
Gilles Ponchel
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Systemic Delivery ◽  
Bioactive Materials ◽  
Mucosal Drug Delivery

scholarly journals Strategies to Prolong the Intravaginal Residence Time of Drug Delivery Systems

2009 ◽  
Vol 12 (3) ◽  
pp. 312 ◽  
Author(s):  
Esra Baloglu ◽  
Andreas Bernkop-Schnürch ◽  
Sinem Yaprak Karavana ◽  
Zeynep Ay Senyigit
Keyword(s):  
Drug Delivery ◽  
Residence Time ◽  
Drug Delivery Systems ◽  
Sol Gel ◽  
Delivery Systems ◽  
Time Base ◽  
Systemic Delivery ◽  
Vaginal Tissue ◽  
Sol Gel Transition

The vagina has been studied as a favorable site for local and systemic delivery of drugs for female-related conditions. There are a large number of vaginal medications on the market and most of them require frequent application due to their short vaginal residence time. A prolonged vaginal residence time of formulations is therefore a key parameter for improved therapeutic efficacy. Promising approaches to prolong the residence time base on mucoadhesion, in- situ sol-gel transition and mechanical fixation. Mucoadhesive drug delivery systems can be tailored to adhere to the vaginal tissue. In-situ gelling systems offer the advantage of increased viscosity in vaginal cavity and consequently reduce outflow from the vagina. Mechanical fixation needs specially shaped drug delivery systems and reduce the frequency of administration significantly. Within this review an overview on these different strategies and systems is provided. Furthermore, the techniques to evaluate the potential of these systems for prolonged vaginal residence time are described.

An overview of in vitro dissolution/release methods for novel mucosal drug delivery systems

2018 ◽  
Vol 147 ◽  
pp. 350-366 ◽  
Author(s):  
Mario Jug ◽  
Anita Hafner ◽  
Jasmina Lovrić ◽  
Maja Lusina Kregar ◽  
Ivan Pepić ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
In Vitro Dissolution ◽  
Mucosal Drug Delivery

scholarly journals Modeling the Oral Cavity with Mucoadhesive Drug Delivery Systems - A Potential Alternative to Conventional Therapy

2017 ◽  
Vol 9 (06) ◽  
Author(s):  
A. Deevan Paul ◽  
P. Samatha ◽  
S. Manasa ◽  
R. Munemma ◽  
D. Supriya
Keyword(s):  
Drug Delivery ◽  
Oral Cavity ◽  
Drug Delivery System ◽  
Delivery System ◽  
Conventional Therapy ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Potential Alternative ◽  
Mucosal Drug Delivery

Oral mucosal drug delivery system is widely applicable as novel site for administration of drug and controlled release action by preventing first pass metabolism and enzymatic degradation due to GI microbial flora. The oral cavity represents a challenging area to develop an effective drug delivery modelling. This arises due to the various inherent functions of the oral cavity (eating, swallowing, speaking, chewing), as well as the presence of the fluid that is involved in all these activities, saliva. This fluid is continually secreted into and then removed from the mouth. Oral Mucosa drug delivery system provides local and systemic action. The delivery of drugs through the buccal mucosa has attracted much research interest over the past two decades and numerous approaches, both conventional and complex, have been developed in an attempt to deliver a variety of pharmaceutical compounds via the buccal route. To outline the progress in the in vitro and in vivo modeling of Mucosal drug delivery and provide a critical review of currently used methods. The purpose of this review is to represent the modeling of oral cavity with Mucoadhesive drug delivery systems and clarify the potential alternative to conventional therapy.

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