Molecular aspects of immune response and infectious diseases (Advances in Host Defense Mechanisms, vol. 7)

1991 ◽  
Vol 7 (7) ◽  
pp. 187
Author(s):  
Paul M. Kaye
Keyword(s):  
Immune Response ◽  
Infectious Diseases ◽  
Host Defense ◽  
Defense Mechanisms ◽  
Molecular Aspects

scholarly journals Differential Regulation of the Immune Response in the Spleen and Liver of Mice Infected withLeishmania donovani

2012 ◽  
Vol 2012 ◽  
pp. 1-7 ◽  
Author(s):  
Rashmi Bankoti ◽  
Simona Stäger
Keyword(s):  
Immune Response ◽  
Immune Responses ◽  
Host Defense ◽  
Defense Mechanisms ◽  
Leishmania Donovani ◽  
Differential Regulation ◽  
Therapeutic Interventions ◽  
Adaptive Immune Responses ◽  
Adaptive Immune ◽  
Novel Therapeutic

Immunity to pathogens requires generation of effective innate and adaptive immune responses.Leishmania donovanievades these host defense mechanisms to survive and persist in the host. A better understanding and identification of mechanisms thatL. donovaniemploys for its survival is critical for developing novel therapeutic interventions that specifically target the parasite. This paper will highlight some of the mechanisms that the parasite utilizes for its persistence and also discuss how the immune response is regulated.

Host Defense Mechanisms in the Gastrointestinal Tract

PEDIATRICS ◽  
1976 ◽  
Vol 57 (6) ◽  
pp. 901-916
Author(s):  
W. Allan Walker
Keyword(s):  
Immune Response ◽  
Gastrointestinal Tract ◽  
Host Defense ◽  
Defense Mechanisms ◽  
Intestinal Flora ◽  
Oral Route ◽  
Cell Mediated Immunity ◽  
Host Defenses ◽  
Human Colostrum ◽  
Gastric Barrier

In this review of host defense mechanisms in the gastrointestinal tract, I have attempted to update the current conception of basic host defenses. Nonimmunologic defenses such as indigenous intestinal flora, peristalsis, secretions, gastric barrier, and antibacterial substances (lysozymes, bile salts, and natural antibodies) were discussed with respect to their contribution in preventing the penetration of microorganisms, enterotoxins, and other antigens across the mucosal surface. The local immunologic system, including SIgA, cell-mediated immunity and other immunoglobulins were discussed. It was emphasized that the immune response at epithelial surfaces was independent from the systemic immune response and related to the antigenic stimulus at the epithelium. Several conditions, including prematurity, malnutrition, and primary immunodeficiencies, were reviewed in order to illustrate that altered host defenses may predispose to pathologic uptake of antigens from the gut and the development of clinical disease. Finally, it was suggested that an approach to the management of these conditions requires the passive replacement of defense substances by an oral route in order to maintain protection within the gastrointestinal lumen. The use of human colostrum/milk as a substitute was suggested.

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