Protective effect of sodium molybdate against the acute toxicity of cadmium chloride

Toxicology ◽  
1990 ◽  
Vol 60 (3) ◽  
pp. 235-243 ◽  
Author(s):  
Yasuhiro Yamane ◽  
Mikiko Fukuchi ◽  
Chiko Li ◽  
Toshiaki Koizumi
Keyword(s):  
Acute Toxicity ◽  
Protective Effect ◽  
Cadmium Chloride ◽  
Sodium Molybdate

scholarly journals Protective effect of butylated hydroxytoluene (BHT) against the clastogenic acitivity of cadmium chloride and potassium dichromate in hamster ovary cells

1999 ◽  
Vol 22 (1) ◽  
pp. 59-64 ◽  
Author(s):  
Claudia A. Grillo ◽  
Analía I. Seoane ◽  
Fernando N. Dulout
Keyword(s):  
Protective Effect ◽  
Chromosomal Aberration ◽  
Cho Cells ◽  
Cadmium Chloride ◽  
Potassium Dichromate ◽  
Chinese Hamster ◽  
Butylated Hydroxytoluene ◽  
Chromosomal Damage ◽  
Combined Treatments ◽  
Chromatin Bridges

The effect of butylated hydroxytoluene (BHT), a widely used food additive, on chromosomal alterations induced by cadmium chloride (CC) and potassium dichromate (PD) in Chinese hamster ovary (CHO) cells was studied both at metaphase and anaphase-telophase. CHO cells were cultured for 15-16 h in the presence of PD (6.0, 9.0 or 12.0 <FONT FACE="Symbol">m</font>M), BHT (1.0 <FONT FACE="Symbol">m</font>g/ml), or PD plus BHT as well as CC (0.5, 1.0 and 2.0 <FONT FACE="Symbol">m</font>M), BHT or CC plus BHT for the analysis of chromosomal aberrations. To perform the anaphase-telophase test, cells were cultured in cover glasses and treated 8 h before fixation with the same chemicals. An extra dose of CC (4 <FONT FACE="Symbol">m</font>M) was used in this test. Both metal salts significantly increased chromosomal aberration frequencies in relation to untreated controls, and to DMSO- and BHT-treated cells. Post-treatment with BHT decreased the yield of chromosomal damage in relation to treatments performed with CC and PD. However, chromosomal aberration frequencies were significantly higher than those of the controls. In the anaphase-telophase test, CC significantly increased the yield of lagging chromosomes with the four doses employed and the frequency of lagging fragments with the highest dose. In combined treatments of CC and BHT, frequencies of the two types of alterations decreased significantly in relation to the cells treated with CC alone. No significant variation was found in the frequencies of chromatin bridges. Significant increases of numbers of chromatin bridges, lagging chromosomes and lagging fragments were found in cells treated with PD. The protective effect of BHT in combined treatments was evidenced by the significant decrease of chromatid bridges and lagging chromosomes in relation to PD-treated cells. Whereas BHT is able to induce chromosomal damage, it can also protect against oxidative damage induced by other genotoxicants.

Protective Effect of Grape and Apple Juices against Cadmium Intoxication in the Kidney of Rats

Drug Research ◽  
2020 ◽  
Vol 70 (11) ◽  
pp. 503-511
Author(s):  
Bianca Andrade Handan ◽  
Carolina Foot Gomes De Moura ◽  
Caroline Margonato Cardoso ◽  
Aline Boveto Santamarina ◽  
Luciana Pellegrini Pisani ◽  
...  
Keyword(s):  
Protective Effect ◽  
Cadmium Chloride ◽  
Apple Juice ◽  
Tissue Injury ◽  
Grape Juice ◽  
Control Group ◽  
Histopathological Analysis ◽  
Gene Expressions ◽  
Cadmium Intoxication ◽  
Male Wistar Rats

Abstract Background The objective of this study was to evaluate protective effect of grape and apple juices against toxicity induced by cadmium in the kidney of rats. Methods A total of 20 male-Wistar rats were distributed into four groups (n=5): Control group: animals received an intraperitoneal (i.p.) injection of 0.9% saline solution and after 15 days, 1 mL of water was administered for 15 days, via gavage; Cadmium group: animals received an intraperitoneal injection of cadmium chloride (1.2 mg/kg) and after 15 days, 1 mL of water was administered for 15 days via gavage; Cadmium+Grape Juice: animals received an i.p. injection of cadmium chloride (1.2 mg/kg), and after 15 days, 0.8 mL of grape juice was administered for 15 days, via gavage; Cadmium+Apple Juice: animals received i.p. injection of cadmium chloride (1.2 mg/kg) and after 15 days, 1.0 mL of apple juice was administered for 15 days, via gavage. Results Histopathological analysis revealed severe tubular lesion and necrosis in the group exposed to cadmium, while animals exposed to grape or apple juices showed a significant reduction of tissue injury. 8-OHdG immunoexpression, DNA damage, cytochrome C and catalase gene expressions and Toll like signaling pathway (TLR2, and pIKKα/β) decreased in animals treated with grape juice when compared to cadmium group. Conclusion Taken together, we conclude that grape and apple juices had a protective effect by means of antioxidant, antigenotoxic actions and for promoting tissue regeneration in the kidney of rats following cadmium intoxication.

Protective effect of sulfhydryl compounds on acute toxicity of morphinone

Life Sciences ◽  
1982 ◽  
Vol 30 (13) ◽  
pp. 1121-1127 ◽  
Author(s):  
Kunisuke Nagamatsu ◽  
Yasumasa Kido ◽  
Tadao Terao ◽  
Takashi Ishida ◽  
Satoshi Toki
Keyword(s):  
Acute Toxicity ◽  
Protective Effect ◽  
Sulfhydryl Compounds

Oral cadmium chloride intoxication in mice: Diethyldithiocarbamate enhances rather than alleviates acute toxicity

Toxicology ◽  
1988 ◽  
Vol 52 (3) ◽  
pp. 331-342 ◽  
Author(s):  
Ole Andersen ◽  
Jesper Bo Nielsen ◽  
Per Svendsen
Keyword(s):  
Acute Toxicity ◽  
Cadmium Chloride

scholarly journals Evaluation of Safety and Protective Effect of Combined Extract ofCissampelos pareiraandAnethum graveolens(PM52) against Age-Related Cognitive Impairment

2012 ◽  
Vol 2012 ◽  
pp. 1-10 ◽  
Author(s):  
Wipawee Thukham-mee ◽  
Jintanaporn Wattanathorn
Keyword(s):  
Cognitive Impairment ◽  
Acute Toxicity ◽  
Protective Effect ◽  
Underlying Mechanism ◽  
Food Supplement ◽  
Anethum Graveolens ◽  
Neuron Density ◽  
Age Related ◽  
Male Wistar Rats ◽  
Oecd Guideline

The present study aimed to determine acute toxicity, the protective effect, and underlying mechanism of PM52, a combined extract ofCissampelos pareiraandAnethum graveolens,against age-related cognitive impairment in animal model of age-related cognitive impairment. PM52 was determined as acute toxicity according to OECD guideline. Male Wistar rats, weighing 180–220 g, were orally given PM52 at doses of 2, 10, and 50 mg/kg at a period of 14 days before and 7 days after the bilateral administration of AF64A via intracerebroventricular route. All animals were assessed according to spatial memory, neuron density, MDA level, the activities of SOD, CAT, GSH-Px, and AChEI effect in hippocampus. It was found that all doses of PM52 could attenuate memory impairment and neurodegeneration in hippocampus. The possible mechanisms might occur via the suppression of AChE and the decreased oxidative stress in hippocampus. Therefore, our data suggest that PM52 may serve as food supplement to protect against age-related cognitive impairment such as mild cognitive impairment (MCI) and early phase of Alzheimer’s disease. However, further researches are still essential.

Sign in / Sign up

Export Citation Format

Share Document