A possible interaction of single-strand binding protein and RecA protein during post-ultraviolet DNA synthesis

Biochimie ◽  
1991 ◽  
Vol 73 (4) ◽  
pp. 515-517 ◽  
Author(s):  
Zˇ. Trovcˇević ◽  
M. Petranović ◽  
K. Brcˇić-Kostić ◽  
D. Petranović ◽  
N. Lersˇ ◽  
...  
Keyword(s):  
Dna Synthesis ◽  
Binding Protein ◽  
Reca Protein ◽  
Single Strand

Post-ultraviolet DNA Synthesis in the Absence of Repair: Role of the Single-strand DNA-binding Protein

1989 ◽  
Vol 55 (5) ◽  
pp. 739-745 ◽  
Author(s):  
Ž. Trgovčević ◽  
N. Lerš ◽  
K. Brčić-Kostić ◽  
E. Salaj-Šmic
Keyword(s):  
Dna Binding ◽  
Dna Synthesis ◽  
Binding Protein ◽  
Dna Binding Protein ◽  
Single Strand

scholarly journals Single-strand binding protein enhances fidelity of DNA synthesis in vitro.

1979 ◽  
Vol 76 (12) ◽  
pp. 6331-6335 ◽  
Author(s):  
T. A. Kunkel ◽  
R. R. Meyer ◽  
L. A. Loeb
Keyword(s):  
Dna Synthesis ◽  
Binding Protein ◽  
Single Strand

Genotoxicity and Cell Proliferative Activity of 3-Chloro-4-(Dichloromethyl)-5-Hydroxy-2(5H)-Furanone [MX] in Rat Glandular Stomach

1992 ◽  
Vol 25 (11) ◽  
pp. 341-345 ◽  
Author(s):  
C. Furihata ◽  
M. Yamashita ◽  
N. Kinae ◽  
T. Matsushima
Keyword(s):  
Cell Proliferation ◽  
Body Weight ◽  
Dna Synthesis ◽  
Ornithine Decarboxylase ◽  
Tap Water ◽  
Fold Increase ◽  
Single Strand ◽  
Glandular Stomach ◽  
Decarboxylase Activity ◽  
Pyloric Mucosa

MX is a strong direct acting mutagen on Salmonella typhimurium TA100 and is present in chlorinated tap water which contains organic compounds. MX was administered orally to 7-week-old male F344 rats, and its geno-toxicity in the pyloric mucosa of stomach was examined by analysis of DNA single strand scissions by the alkaline elution method. The effect of MX on cell proliferation was examined by assays of the inductions of replicative DNA synthesis and ornithine decarboxylase. MX at closes of 20-48 mg/kg body weight induced DNA single strand scissions dose-dependently (p<0.02) in the pyloric mucosa of the stomach 2 h after its administration. Moreover at doses of 10-60 mg/kg body weight, it induced up to 21-fold increase in replicative DNA synthesis (p<0.01) 16 h after its administration. At doses of 10-60 mg/kg body weight, it induced up to 100-fold increase in ornithine decarboxylase activity with a maximum 16 h after its administration. These results suggest that MX is genotoxic and induces cell proliferation in the glandular stomach of rats.

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