Ethylidene glucose-substituted new analogue of streptozotocin cannot induce diabetes: Study on the basis of structure and activity relationship

1989 ◽  
Vol 62 (2) ◽  
pp. 153-159 ◽  
Author(s):  
Kawada Jun ◽  
Okita Miho ◽  
Nukatsuka Mamoru ◽  
Toyooka Kouhei ◽  
Naito Shinsaku ◽  
...  
Keyword(s):  
Activity Relationship ◽  
Structure And Activity

Cobalt oxide decorated porous silica particles: structure and activity relationship in the catalytic oxidation of carbon monoxide

2021 ◽  
pp. 152121
Author(s):  
Daniil A. Eurov ◽  
Tatiana N. Rostovshchikova ◽  
Marina I. Shilina ◽  
Demid A. Kirilenko ◽  
Maria V. Tomkovich ◽  
...  
Keyword(s):  
Carbon Monoxide ◽  
Catalytic Oxidation ◽  
Cobalt Oxide ◽  
Porous Silica ◽  
Silica Particles ◽  
Activity Relationship ◽  
Structure And Activity ◽  
Oxidation Of Carbon Monoxide

scholarly journals FLAVONES AND FLAVANONES AS ACHETYLCHOLINESTERASE INHIBITORS: THE STRUCTURE-ACTIVITY RELATIONSHIP AND MOLECULAR DOCKING STUDIES

2021 ◽  
Vol 59 (4) ◽  
pp. 441
Author(s):  
Hoàng Thị Kim Dung ◽  
Hoang-Phuc Nguyen ◽  
Thi-Kim-Chi Huynh
Keyword(s):  
Molecular Docking ◽  
Docking Study ◽  
Docking Studies ◽  
Activity Relationship ◽  
Binding Modes ◽  
Flower Buds ◽  
Molecular Docking Study ◽  
Structure Activity ◽  
Relationship Of ◽  
Structure And Activity

Discovering and developing drugs to treat Alzheimer's disease (AD) have been a crucial target for many decades. According to a large number of later studies, acetylcholinesterase (AChE) plays an important role in AD treatment. On the other hand, flavonoids are natural compounds that possessed a wide variety of bioactivities, including the inhibitory activity on AChE. In this study, we reported the structure and activity relationship of flavone and flavanone derivatives that semi-synthesized and synthesized from flower buds of Styphnolobium japonicum (Leguminosae) and citrus peels against AChE. The results showed that the introducing of the new functional groups that leads to increasing 3-folds better AChE inhibition of compound Q2 and Q4 than that of the original. The molecular docking study was investigated in order to illuminate the experimental results and find their binding modes.

Some New Derivatives of Harmaline Series of Bases

1986 ◽  
Vol 41 (12) ◽  
pp. 1583-1586 ◽  
Author(s):  
Salimuzzaman Siddiqui ◽  
Bina S. Siddiqui ◽  
Sabira Begum
Keyword(s):  
Physiological Activity ◽  
Activity Relationship ◽  
Spectral Studies ◽  
Chemical Studies ◽  
Pharmacological Screening ◽  
Derivatives Of ◽  
Structure And Activity

AbstractIn the course of pharmaco-chemical studies in the structure and activity relationship in harmaline series of β-carboline bases, a number of new derivatives of harmaline have been obtained and characterized through chemical and spectral studies. Pharmacological screening carried out on one of these (9) shows that it has mild physiological activity without any toxicity.

Oxidative Conversion Mediates Antiproliferative Effects of tert-Butylhydroquinone: Structure and Activity Relationship Study

2016 ◽  
Vol 64 (19) ◽  
pp. 3743-3748 ◽  
Author(s):  
Katherine Z. Sanidad ◽  
Elvira Sukamtoh ◽  
Weicang Wang ◽  
Zheyuan Du ◽  
Ellie Florio ◽  
...  
Keyword(s):  
Activity Relationship ◽  
Oxidative Conversion ◽  
Antiproliferative Effects ◽  
Relationship Study ◽  
Structure And Activity
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