Capsaicin-induced substance P release and sensory control of vascular permeability in the guinea-pig ureter

1983 ◽  
Vol 41 (1-2) ◽  
pp. 167-172 ◽  
Author(s):  
A. Saria ◽  
J.M. Lundberg ◽  
X. Hua ◽  
F. Lembeck
Keyword(s):  
Substance P ◽  
Guinea Pig ◽  
Vascular Permeability ◽  
Sensory Control ◽  
P Release ◽  
Substance P Release

scholarly journals Neurogenic Inflammation of Guinea-Pig Bladder

1994 ◽  
Vol 3 (3) ◽  
pp. 189-197 ◽  
Author(s):  
D. E. Bjorling ◽  
M. R. Saban ◽  
R. Saban
Keyword(s):  
Substance P ◽  
Guinea Pig ◽  
Neurogenic Inflammation ◽  
Calcium Ionophore ◽  
Cyclic Pattern ◽  
Bladder Tissue ◽  
Histological Changes ◽  
P Release ◽  
Substance P Release

Capsaicin, substance P, and ovalbumin, instilled into the bladders of naive and ovalbumin (OVA) sensitized guineapigs caused inflammation, as indicated by increased vascular permeability. Histological changes after exposure to these compounds progressed with time from intense vasodilatation to marginalization of granulocytes followed by interstitial migration of leukocytes.In vitroincubation of guinea-pig bladder tissue with substance P and ovalbumin stimulated release of prostaglandin D2and leukotrienes.In vitroincubation of bladder tissue with capsaicin, OVA, prostaglandin D2, leukotriene C4, histamine, or calcium ionophore A-23587 all stimulated substance P release. These data suggest that bladder inflammation initiated by a variety of stimuli could lead to a cyclic pattern of release of inflammatory mediators and neuropeptides, which could result in amplification and persistence of cystitis after the inciting cause has subsided.

Calcium and capsaicin- induced substance P release from peripheral terminals of primary sensory neurons

1988 ◽  
Vol 22 (1-2) ◽  
pp. 117 ◽  
Author(s):  
C.A. Maggi ◽  
P. Santicioli ◽  
P. Geppetti ◽  
R. Patacchini ◽  
E. Del Bianco ◽  
...  
Keyword(s):  
Substance P ◽  
Sensory Neurons ◽  
Primary Sensory Neurons ◽  
P Release ◽  
Substance P Release

scholarly journals Sufentanil, Morphine, Met-enkephalin, and k-Agonist (U-50,488H) Inhibit Substance P Release from Primary Sensory Neurons

1989 ◽  
Vol 70 (4) ◽  
pp. 672-677 ◽  
Author(s):  
H. Ming Chang ◽  
Charles B. Berde ◽  
George G. Holz ◽  
Grieg F. Steward ◽  
Richard M. Kream
Keyword(s):  
Substance P ◽  
Sensory Neurons ◽  
Primary Sensory Neurons ◽  
P Release ◽  
Inhibit Substance ◽  
Substance P Release

scholarly journals Hypertonicity, but not hypothermia, elicits substance P release from rat C-fiber neurons in primary culture.

1995 ◽  
Vol 95 (5) ◽  
pp. 2359-2366 ◽  
Author(s):  
A Garland ◽  
J E Jordan ◽  
J Necheles ◽  
L E Alger ◽  
M M Scully ◽  
...  
Keyword(s):  
Substance P ◽  
Primary Culture ◽  
P Release ◽  
C Fiber ◽  
Substance P Release

scholarly journals Effects of General Anesthetics on Substance P Release and c-Fos Expression in the Spinal Dorsal Horn

2013 ◽  
Vol 119 (2) ◽  
pp. 433-442 ◽  
Author(s):  
Toshifumi Takasusuki ◽  
Shigeki Yamaguchi ◽  
Shinsuke Hamaguchi ◽  
Tony L. Yaksh
Keyword(s):  
Nitrous Oxide ◽  
Substance P ◽  
Dorsal Horn ◽  
Receptor Internalization ◽  
General Anesthetics ◽  
Neurokinin 1 Receptor ◽  
P Release ◽  
Fos Expression ◽  
Neurokinin 1 ◽  
Substance P Release

Abstract Background: The authors examined in vivo the effects of general anesthetics on evoked substance P release (primary afferent excitability) and c-Fos expression (neuronal activation) in superficial dorsal horn. Methods: Rats received saline, propofol (100 mg/kg), pentobarbital (50 mg/kg), isoflurane (2 minimum alveolar concentration), nitrous oxide (66%), or fentanyl (30 μg/kg). During anesthesia, rats received intraplantar 5% formalin (50 μl) to left hind paw. Ten minutes later, rats underwent transcardial perfusion with 4% paraformaldehyde. Substance P release from small primary afferents was assessed by incidence of neurokinin 1 receptor internalization in the superficial dorsal horn. In separate studies, rats were sacrificed after 2 h and c-Fos expression measured. Results: Intraplantar formalin-induced robust neurokinin 1 receptor internalization in ipsilateral dorsal horn (ipsilateral: 54 ± 6% [mean ± SEM], contralateral: 12 ± 2%; P < 0.05; n = 4). Fentanyl, but not propofol, pentobarbital, isoflurane, nor nitrous oxide alone inhibited neurokinin 1 receptor internalization. However, 2 minimum alveolar concentration isoflurane + nitrous oxide reduced neurokinin 1 receptor internalization (27 ± 3%; P < 0.05; n = 5). All agents reduced c-Fos expression (control: 34 ± 4, fentanyl: 8 ± 2, isoflurane: 12 ± 3, nitrous oxide: 11 ± 2, isoflurane + nitrous oxide: 12 ± 1, pentobarbital: 11 ± 2, propofol: 13 ± 3; P < 0.05; n = 3). Conclusion: General anesthetics at anesthetic concentrations block spinal neuron activation through a mechanism that is independent of an effect on small primary afferent peptide release. The effect of fentanyl alone and the synergistic effect of isoflurane and nitrous oxide on substance P release suggest a correlative rationale for the therapeutic use of these anesthetic protocols by blocking nociceptive afferent transmitter release and preventing the initiation of cascade, which is immediately postsynaptic to the primary afferent.

scholarly journals Sensory neurons accelerate reepithelialization through Substance P release in an innervated tissue‐engineered model of skin wound healing.

2013 ◽  
Vol 27 (S1) ◽  
Author(s):  
Mathieu Blais ◽  
Lorène Mottier ◽  
Sébastien Cadau ◽  
Rémi Parenteau‐ Bareil ◽  
François Berthod
Keyword(s):  
Wound Healing ◽  
Substance P ◽  
Sensory Neurons ◽  
Skin Wound ◽  
Skin Wound Healing ◽  
P Release ◽  
Substance P Release

Spinal substance P release in vivo during the induction of long-term potentiation in dorsal horn neurons

Pain ◽  
2002 ◽  
Vol 96 (1) ◽  
pp. 49-55 ◽  
Author(s):  
Abdullahi Warsame Afrah ◽  
Atle Fiskå ◽  
Johannes Gjerstad ◽  
Henrik Gustafsson ◽  
Arne Tjølsen ◽  
...  
Keyword(s):  
Substance P ◽  
Dorsal Horn ◽  
Long Term Potentiation ◽  
Dorsal Horn Neurons ◽  
P Release ◽  
Term Potentiation ◽  
Substance P Release
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