Age-related variations in plasma and liver lipids of Yoshida rats: a comparison with Wistar rats

1995 ◽  
Vol 111 (2) ◽  
pp. 319-327 ◽  
Author(s):  
R. Masella ◽  
E. Pignatelli ◽  
T. Marinelli ◽  
D. Modesti ◽  
R. Verna ◽  
...  
Keyword(s):  
Wistar Rats ◽  
Liver Lipids ◽  
Age Related ◽  
Plasma And Liver Lipids

Age-related changes in blood and liver lipids of male wistar rats

1993 ◽  
Vol 16 (3) ◽  
pp. 249-262 ◽  
Author(s):  
Alfredo Cantafora ◽  
Roberta Masella ◽  
Elena Pignatelli ◽  
Roberto Verna
Keyword(s):  
Wistar Rats ◽  
Liver Lipids ◽  
Age Related ◽  
Male Wistar Rats ◽  
Age Related Changes

Renal Cortical Slices: An In Vitro Model for Kidney Metabolism and Toxicity

1992 ◽  
Vol 20 (1) ◽  
pp. 71-76
Author(s):  
Andrea Trevisan ◽  
Stefano Maso ◽  
Paola Meneghetti
Keyword(s):  
Wistar Rats ◽  
Reduced Glutathione ◽  
Organic Anion ◽  
Cortical Slice ◽  
Lactate Dehydrogenase Release ◽  
Age Related ◽  
Renal Cortical Slice ◽  
Male Wistar Rats ◽  
Vitro Model

The in vitro renal cortical slice model was used to study: 1) the effects on the kidney of some haloalkanes and haloalkenes using 3-month-old male Wistar rats; 2) influence of age and sex on renal cortical slice indices in non-treated rats; and 3) effects of 1,2-dichloropropane on the slices after pretreatment of 3-month-old male Wistar rats with DL-butathionine-[S,R]-sulphoximine. The most nephrotoxic chemical used was 1,3-dichloropropene, which caused a total depletion in the levels of reduced glutathione, a high peroxidation of lipid (about three thousand-fold with respect to control), a significant release of tubular enzymes into the medium, and loss of organic anion ( p-aminohippurate) accumulation. All the chemicals affected the cytosol more than the brush border. The most remarkable age-related differences in the untreated slices were the progressive decrease of reduced glutathione (p<0.05 from three months of age), and an increase in lactate dehydrogenase release into the medium (p<0.05 from six months of age). By contrast, sex differences were slight. The ‘treatment with 1,2-dichloropropane of slices prepared from rats pretreated with DL-butathionine-[S,R]-sulphoximine significantly increased the depletion of glutathione content (p<0.05) and malondialdehyde release in the medium (p<0.001) caused by the solvent alone.

scholarly journals Effects of soya milk and Bifidobacterium-fermented soya milk on plasma and liver lipids, and faecal steroids in hamsters fed on a cholesterol-free or cholesterol-enriched diet

1998 ◽  
Vol 79 (1) ◽  
pp. 97-105 ◽  
Author(s):  
H. Kikuchi-Hayakawa ◽  
N. Onodera ◽  
S. Matsubara ◽  
E. Yasuda ◽  
Y. Shimakawa ◽  
...  
Keyword(s):  
Bile Acid ◽  
Total Cholesterol ◽  
Ldl Cholesterol ◽  
Diet Group ◽  
Acid Excretion ◽  
Liver Lipids ◽  
Soya Milk ◽  
Bile Acid Excretion ◽  
Steroid Excretion ◽  
Plasma And Liver Lipids

The effects of freeze-dried soya milk (SM) and Bifidobacterium-fermented soya milk (FSM) on plasma and liver lipids, and faecal steroid excretion were estimated in hamsters fed on a cholesterol-free or cholesterol-enriched diet. Hamsters fed on the cholesterol-free diet containing 300 g FSM/kg had lower levels of plasma VLDL + LDL cholesterol than the animals fed on the control diet. SM in the diet produced a similar pattern without significant differences. In the cholesterol-enriched diet group, SM and FSM decreased the levels of plasma total cholesterol and VLDL + LDL-cholesterol. SM and FSM decreased the plasma triacylglycerol level in both the cholesterol-free and -enriched diet groups. The liver total cholesterol contents in the SM and FSM groups were lower than that in the control group, for hamsters fed on the cholesterol-free diet. The liver triacylglycerol content was not modified by SM or FSM in hamsters fed on either the cholesterol-free or -enriched diet. SM and FSM increased the total bile acid excretion and the proportion of cholesterol entering the cholic acid biosynthesis pathway in both the cholesterol-free and -enriched diet groups. SM and FSM did not affect neutral steroid excretion in the cholesterol-free or -enriched diet group. There was an inverse relationship between VLDL + LDL-cholesterol and faecal bile acid excretion in hamsters fed on the cholesterol-free (r −0.670, P < 0.01) and cholesterol-enriched (r −0.761, P < 0.001) diets respectively. These results indicated that SM had an anti-atherogenic effect, and that this effect was not diminished by prior fermentation.

Effect of proteins from beef, pork, and turkey meat on plasma and liver lipids of rats compared with casein and soy protein

Nutrition ◽  
2006 ◽  
Vol 22 (11-12) ◽  
pp. 1162-1170 ◽  
Author(s):  
Corinna Brandsch ◽  
Anjali Shukla ◽  
Frank Hirche ◽  
Gabriele I. Stangl ◽  
Klaus Eder
Keyword(s):  
Soy Protein ◽  
Liver Lipids ◽  
Turkey Meat ◽  
Plasma And Liver Lipids

scholarly journals Comparative studies on the hypercholesterolaemia induced by excess dietary tyrosine or polychlorinated biphenyls in rats

1986 ◽  
Vol 56 (2) ◽  
pp. 509-517 ◽  
Author(s):  
Sahoshi Nagaoka ◽  
Mitsuhiro Kato ◽  
Yoritaka Aoyama ◽  
Akira Yoshida†
Keyword(s):  
Ascorbic Acid ◽  
Polychlorinated Biphenyls ◽  
Comparative Studies ◽  
Wistar Rats ◽  
Serum Levels ◽  
Liver Lipids ◽  
Male Wistar Rats

1. The effects of dietary polychlorinated biphenyls (PCB) and excess tyrosine on serum and liver lipids, urinary ascorbic acid and catecholamines were compared in male Wistar rats.2. Serum levels of cholesterol, urinary ascorbic acid, norepinephrine, epinephrine, dopamine and histamine were significantly increased in rats given either PCB or excess tyrosine.3. The hypercholesterolaemia induced by PCB or excess tyrosine was blocked by the adrenergic α-blocker, phenoxybenzamine.4. The present results suggest causal interrelations between the hypercholesterolaemia induced by dietary PCB or excess tyrosine and the secretion of catecholamines.

scholarly journals Age-Induced Loss of Mossy Fibre Synapses on CA3 Thorns in the CA3 Stratum Lucidum

2013 ◽  
Vol 2013 ◽  
pp. 1-8 ◽  
Author(s):  
Bunmi Ojo ◽  
Heather Davies ◽  
Payam Rezaie ◽  
Paul Gabbott ◽  
Francis Colyer ◽  
...  
Keyword(s):  
Wistar Rats ◽  
Synaptic Connection ◽  
Mossy Fibre ◽  
Synaptic Density ◽  
Cellular Processes ◽  
Unbiased Stereology ◽  
Microvascular Changes ◽  
Age Related ◽  
Stratum Lucidum ◽  
Serial Electron Microscopy

Advanced ageing is associated with hippocampal deterioration and mild cognitive decline. The hippocampal subregion CA3 stratum lucidum (CA3-SL) receives neuronal inputs from the giant mossy fibre boutons of the dentate gyrus, but relatively little is known about the integrity of this synaptic connection with ageing. Using serial electron microscopy and unbiased stereology, we examined age-related changes in mossy fibre synapses on CA3 thorny excrescences within the CA3-SL of young adults (4-month-old), middle-aged (12-month-old), and old-aged (28-month-old) Wistar rats. Our data show that while there is an increase in CA3 volume with ageing, there is a significant (40–45%) reduction in synaptic density within the CA3-SL of 12- and 28-month-old animals compared with 4-month-old animals. We also present preliminary data showing that the CA3 neuropil in advanced ageing was conspicuously full of lipofuscin and phagolysosome positive, activated microglial cellular processes, and altered perivascular pathology. These data suggest that synaptic density in the CA3-SL is significantly impaired in ageing, accompanied by underlying prominent ultrastructural glial and microvascular changes.

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