Incidence of thermal injury and radiation induced early and late normal tissue reactions in a phase III trial comparing radiotherapy alone (XRT) and heat combined with radiation (Δ + XRT)

1984 ◽  
Vol 10 ◽  
pp. 110 ◽  
Author(s):  
Mark W. Dewhirst ◽  
Dalice A. Sim ◽  
Kathryn Grochowski
Keyword(s):  
Normal Tissue ◽  
Thermal Injury ◽  
Phase Iii ◽  
Phase Iii Trial ◽  
Radiation Induced ◽  
Radiotherapy Alone ◽  
Tissue Reactions ◽  
Normal Tissue Reactions

Radiation-Induced Comet-Formation in Human Skin Fibroblasts from Radiotherapy Patients with Different Normal Tissue Reactions

1999 ◽  
Vol 175 (7) ◽  
pp. 341-346 ◽  
Author(s):  
Ulrich Oppitz ◽  
Stefan Denzinger ◽  
Uschi Nachtrab ◽  
Michael Flentje ◽  
Helga Stopper
Keyword(s):  
Human Skin ◽  
Normal Tissue ◽  
Skin Fibroblasts ◽  
Human Skin Fibroblasts ◽  
Radiation Induced ◽  
Tissue Reactions ◽  
Normal Tissue Reactions

scholarly journals SUPR-3D: A randomized phase iii trial comparing simple unplanned palliative radiotherapy versus 3d conformal radiotherapy for patients with bone metastases: study protocol

BMC Cancer ◽  
2019 ◽  
Vol 19 (1) ◽  
Author(s):  
Robert Olson ◽  
Roel Schlijper ◽  
Nick Chng ◽  
Quinn Matthews ◽  
Marco Arimare ◽  
...  
Keyword(s):  
Bone Metastases ◽  
Volumetric Modulated Arc Therapy ◽  
Palliative Radiotherapy ◽  
Conformal Radiotherapy ◽  
Phase Iii ◽  
Phase Iii Trial ◽  
Patient Reported ◽  
Radiation Induced ◽  
The Difference

Abstract Background Bone metastases in the lower spine and pelvis are effectively palliated with radiotherapy (RT), though this can come with side effects such as radiation induced nausea and vomiting (RINV). We hypothesize that high rates of RINV occur in part because of the widespread use of inexpensive simple unplanned palliative radiotherapy (SUPR), over more complex and resource intensive 3D conformal RT, such as volumetric modulated arc therapy (VMAT). Methods This is a randomized, multi-centre phase III trial of SUPR versus VMAT. We will accrue 250 patients to assess the difference in patient-reported RINV. This study is powered to detect a difference in quality of life between patients treated with VMAT vs. SUPR. Discussion This trial will determine if VMAT reduces early toxicity compared to SUPR and may provide justification for this more resource-intensive and costly form of RT. Trial registration Clinicaltrials.gov identifier: NCT03694015. Date of registration: October 3, 2018.

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