Characterisation of the dihydrofolate reductase-thymidylate synthetase gene from human malaria parasites highly resistant to pyrimethamine

Gene ◽  
1989 ◽  
Vol 76 (1) ◽  
pp. 41-52 ◽  
Author(s):  
Valerie A. Snewin ◽  
Susan M. England ◽  
Paul F.G. Sims ◽  
John E. Hyde
Keyword(s):  
Dihydrofolate Reductase ◽  
Thymidylate Synthetase ◽  
Malaria Parasites ◽  
Human Malaria

Pyrimethamine analogs as strong inhibitors of double and quadruple mutants of dihydrofolate reductase in human malaria parasites

2003 ◽  
Vol 1 (6) ◽  
pp. 960-964 ◽  
Author(s):  
Alireza Sardarian ◽  
Kenneth T. Douglas ◽  
Martin Read ◽  
Paul F. G. Sims ◽  
John E. Hyde ◽  
...  
Keyword(s):  
Dihydrofolate Reductase ◽  
Malaria Parasites ◽  
Human Malaria

scholarly journals Non-human primate and human malaria: past, present and future

2021 ◽  
Author(s):  
Spinello Antinori ◽  
Cecilia Bonazzetti ◽  
Andrea Giacomelli ◽  
Mario Corbellino ◽  
Massimo Galli ◽  
...  
Keyword(s):  
Plasmodium Knowlesi ◽  
Plasmodium Species ◽  
Molecular Techniques ◽  
Malaria Parasites ◽  
Human Malaria ◽  
Complex Interactions ◽  
Zoonotic Malaria ◽  
The Impact ◽  
Human Plasmodium ◽  
Human Primate

Abstract Background Studies of the malaria parasites infecting various non-human primates (NHPs) have increased our understanding of the origin, biology and pathogenesis of human Plasmodium parasites. This review considers the major discoveries concerning NHP malaria parasites, highlights their relationships with human malaria and considers the impact that this may have on attempts to eradicate the disease. Results The first description of NHP malaria parasites dates back to the early 20th century. Subsequently, experimental and fortuitous findings indicating that some NHP malaria parasites can be transmitted to humans have raised concerns about the possible impact of a zoonotic malaria reservoir on efforts to control human malaria. Advances in molecular techniques over the last 15 years have contributed greatly to our knowledge of the existence and geographical distribution of numerous Plasmodium species infecting NHPs, and extended our understanding of their close phylogenetic relationships with human malaria parasites. The clinical application of such techniques has also made it possible to document ongoing spillovers of NHP malaria parasites (Plasmodium knowlesi, P. cynomolgi, P. simium, P. brasilianum) in humans living in or near the forests of Asia and South America, thus confirming that zoonotic malaria can undermine efforts to eradicate human malaria. Conclusions Increasing molecular research supports the prophetic intuition of the pioneers of modern malariology who saw zoonotic malaria as a potential obstacle to the full success of malaria eradication programmes. It is, therefore, important to continue surveillance and research based on one-health approaches in order to improve our understanding of the complex interactions between NHPs, mosquito vectors and humans during a period of ongoing changes in the climate and the use of land, monitor the evolution of zoonotic malaria, identify the populations most at risk and implement appropriate preventive strategies.

scholarly journals A cornucopia of research resources for the fourth rodent malaria parasite species

BMC Biology ◽  
2021 ◽  
Vol 19 (1) ◽  
Author(s):  
Jane M. Carlton
Keyword(s):  
Malaria Parasite ◽  
Parasite Species ◽  
First Century ◽  
Model Systems ◽  
Rodent Malaria Parasite ◽  
Malaria Parasites ◽  
Rodent Malaria ◽  
Human Malaria ◽  
Plasmodium Vinckei ◽  
Research Resources

AbstractThe study of human malaria caused by species of Plasmodium has undoubtedly been enriched by the use of model systems, such as the rodent malaria parasites originally isolated from African thicket rats. A significant gap in the arsenal of resources of the species that make up the rodent malaria parasites has been the lack of any such tools for the fourth of the species, Plasmodium vinckei. This has recently been rectified by Abhinay Ramaprasad and colleagues, whose pivotal paper published in BMC Biology describes a cornucopia of new P. vinckei ‘omics datasets, mosquito transmission experiments, transfection protocols, and virulence phenotypes, to propel this species firmly into the twenty-first century.

scholarly journals Killing of human malaria parasites by macrophage secretory products.

1984 ◽  
Vol 43 (2) ◽  
pp. 664-669 ◽  
Author(s):  
A O Wozencraft ◽  
H M Dockrell ◽  
J Taverne ◽  
G A Targett ◽  
J H Playfair
Keyword(s):  
Malaria Parasites ◽  
Human Malaria ◽  
Secretory Products

Evolutionary Origins of Human Malaria Parasites

2006 ◽  
pp. 125-146 ◽  
Author(s):  
Stephen M. Rich ◽  
Francisco J. Ayala
Keyword(s):  
Malaria Parasites ◽  
Human Malaria ◽  
Evolutionary Origins

scholarly journals Structure, Function and Inhibition of the Phosphoethanolamine Methyltransferases of the Human Malaria Parasites Plasmodium vivax and Plasmodium knowlesi

2015 ◽  
Vol 5 (1) ◽  
Author(s):  
Aprajita Garg ◽  
Tiit Lukk ◽  
Vidya Kumar ◽  
Jae-Yeon Choi ◽  
Yoann Augagneur ◽  
...  
Keyword(s):  
Structure Function ◽  
Plasmodium Vivax ◽  
Plasmodium Knowlesi ◽  
Malaria Parasites ◽  
Human Malaria
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