The action of hydrogen peroxide on paired pulse and long-term potentiation in the hippocampus

1989 ◽  
Vol 7 (1) ◽  
pp. 3-8 ◽  
Author(s):  
Carol A. Colton ◽  
Laurent Fagni ◽  
Daniel Gilberts
Keyword(s):  
Hydrogen Peroxide ◽  
Long Term Potentiation ◽  
Paired Pulse ◽  
Term Potentiation

scholarly journals Pre- and Postnatal Propylthiouracil-Induced Hypothyroidism Impairs Synaptic Transmission and Plasticity in Area CA1 of the Neonatal Rat Hippocampus

Endocrinology ◽  
2003 ◽  
Vol 144 (9) ◽  
pp. 4195-4203 ◽  
Author(s):  
Li Sui ◽  
M. E. Gilbert
Keyword(s):  
Thyroid Hormone ◽  
Synaptic Transmission ◽  
Long Term Potentiation ◽  
Synaptic Function ◽  
Learning Deficits ◽  
Paired Pulse ◽  
Area Ca1 ◽  
Term Potentiation ◽  
Paired Pulse Depression

Abstract Thyroid hormones are essential for neonatal brain development. It is well established that insufficiency of thyroid hormone during critical periods of development can impair cognitive functions. The mechanisms that underlie learning deficits in hypothyroid animals, however, are not well understood. As impairments in synaptic function are likely to contribute to cognitive deficits, the current study tested whether thyroid hormone insufficiency during development would alter quantitative characteristics of synaptic function in the hippocampus. Developing rats were exposed in utero and postnatally to 0, 3, or 10 ppm propylthiouracil (PTU), a thyroid hormone synthesis inhibitor, administered in the drinking water of dams from gestation d 6 until postnatal day (PN) 30. Excitatory postsynaptic potentials and population spikes were recorded from the stratum radiatum and the pyramidal cell layer, respectively, in area CA1 of hippocampal slices from offspring between PN21 and PN30. Baseline synaptic transmission was evaluated by comparing input-output relationships between groups. Paired-pulse facilitation, paired-pulse depression, long-term potentiation, and long-term depression were recorded to examine short- and long-term synaptic plasticity. PTU reduced thyroid hormones, reduced body weight gain, and delayed eye-opening in a dose-dependent manner. Excitatory synaptic transmission was increased by developmental exposure to PTU. Thyroid hormone insufficiency was also dose-dependently associated with a reduction paired-pulse facilitation and long-term potentiation of the excitatory postsynaptic potential and elimination of paired-pulse depression of the population spike. The results indicate that thyroid hormone insufficiency compromises the functional integrity of synaptic communication in area CA1 of developing rat hippocampus and suggest that these changes may contribute to learning deficits associated with developmental hypothyroidism.

Interaction between paired-pulse facilitation and long-term potentiation during the stimulation of the cannabinoid and vanilloid systems in the dentate gyrus

2016 ◽  
Vol 1643 ◽  
pp. 27-34 ◽  
Author(s):  
Lida Tahmasebi ◽  
Alireza Komaki ◽  
Ruhollah Karamian ◽  
Siamak Shahidi ◽  
Abdolrahman Sarihi ◽  
...  
Keyword(s):  
Dentate Gyrus ◽  
Long Term Potentiation ◽  
Paired Pulse ◽  
Paired Pulse Facilitation ◽  
Term Potentiation ◽  
Stimulation Of

Mouse hippocampo-prefrontal paired-pulse facilitation and long-term potentiation in vivo

Neuroreport ◽  
2001 ◽  
Vol 12 (6) ◽  
pp. 1191-1193 ◽  
Author(s):  
Yoshinori Izaki ◽  
Masatoshi Takita ◽  
Masahiko Nomura
Keyword(s):  
Long Term Potentiation ◽  
Paired Pulse ◽  
Paired Pulse Facilitation ◽  
Term Potentiation
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