Production of poly-β-hydroxybutyric acid from carbon dioxide by Alcaligenes eutrophus ATCC 17697T

1991 ◽  
Vol 71 (4) ◽  
pp. 254-257 ◽  
Author(s):  
Ayaaki Ishizaki ◽  
Kenji Tanaka
Keyword(s):  
Carbon Dioxide ◽  
Alcaligenes Eutrophus ◽  
Hydroxybutyric Acid

scholarly journals Insilico Analysis of PHB from Halophiles for potential Bio-medical applications

2019 ◽  
pp. 211-218
Author(s):  
Vinod. P S ◽  
Neha Guttikonda ◽  
Snehal. M. Mathe ◽  
M B Sulochana
Keyword(s):  
Carbon Dioxide ◽  
Nuclear Magnetic Resonance ◽  
Drug Carrier ◽  
Halophilic Bacteria ◽  
Docking Studies ◽  
Medical Applications ◽  
Hydroxybutyric Acid ◽  
Lipinski’S Rule ◽  
Toxicity Analysis

Polyhydroxybutyrate (PHB) is an important biopolymer accumulated by halophilic organisms. PHA is a family of polyesters is accumulated as granules in the cell of bacteria. Polyhydroxybutyrate (PHB) can be used as an alternative polymer to polylactide-glycolides for drug carrier production. It is a linear homopolymer biosynthesized by various strains of bacteria by condensation of D (-)-B-hydroxybutyric acid and used as an energy and carbon source. PHB can be obtained by extraction from bacteria or by chemical synthesis. To be suitable as drug carrier the PHB (polymer) has to be biocompatible, biodegradable in certain applications, and nontoxic. PHB seems to be biocompatible and biodegrades readily to carbon dioxide in bacteria; however, in humans, the reports are few and contradictory. The PHB was extracted from halophilic bacteria. The structural characterization of PHB was done by using NMR (nuclear magnetic resonance). To genenerate SMILES the structure were drawn in MarvinSketch. The PHB were screened based on the Lipinski’s rule of 5. The PHB molecule was subjected to the toxicity analysis and those that passed the toxicity test analyzed for docking studies.

High frequency transformation of Alcaligenes eutrophus producing poly-?-hydroxybutyric acid by electroporation

1995 ◽  
Vol 9 (1) ◽  
pp. 31-34 ◽  
Author(s):  
Hae-Chul Park ◽  
Kyung-Jun Lim ◽  
Jin-Seo Park ◽  
Yong-Hyun Lee ◽  
Tae-Lin Huh
Keyword(s):  
High Frequency ◽  
Alcaligenes Eutrophus ◽  
Hydroxybutyric Acid ◽  
Frequency Transformation ◽  
High Frequency Transformation
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