Long-term follow-up of antibody titers after hepatitis A vaccination

1993 ◽  
Vol 1 (4) ◽  
pp. 194-199 ◽  
Author(s):  
I KURAMOTO ◽  
S FUJIYAMA ◽  
K ODOH ◽  
K MIZUNO ◽  
T SATO
1987 ◽  
Vol 22 (9) ◽  
pp. 1115-1122 ◽  
Author(s):  
R. Wejstål ◽  
J. Lindberg ◽  
P. Lundin ◽  
G. Norkrans

2009 ◽  
Vol 50 (2) ◽  
pp. 388-393 ◽  
Author(s):  
Mårten Werner ◽  
Sven Almer ◽  
Hanne Prytz ◽  
Stefan Lindgren ◽  
Sven Wallerstedt ◽  
...  

2014 ◽  
Vol 50 (2) ◽  
pp. 217-223 ◽  
Author(s):  
Åsa Danielsson Borssén ◽  
Sven Almer ◽  
Hanne Prytz ◽  
Sven Wallerstedt ◽  
Inga-Lill Friis-Liby ◽  
...  

2006 ◽  
Vol 24 (18_suppl) ◽  
pp. 1008-1008 ◽  
Author(s):  
T. F. Schwarz

1008 Background: Genital HPV infections can be acquired shortly after sexual debut, and the risk remains throughout a sexually active woman’s lifetime. In women 15–25 years of age, the AS04-containing HPV vaccine was highly immunogenic and conferred 100% protection against HPV-16/18 persistent infection and associated cervical lesions up to 27 months. In the long-term follow-up of this study, sustained vaccine efficacy has been observed up to 48 months. The present phase III study (580299/014) assessed immune responses to the AS04-containing HPV-16/18 vaccine in women 26–55 years old compared with women 15–25 years old. Methods: Healthy women in Germany and Poland between 15 and 55 years of age received 3 doses of HPV-16/18 AS04-containing vaccine at months 0, 1, and 6. The groups were age stratified: 15–25 (n=229), 26–45 (n=226), and 46–55 (n=211). Anti-HPV-16/18 antibody titers were assessed at months 0, 2, 7, and 12 by ELISA (EU/mL). Seropositivity rates and geometric mean antibody titers (GMTs) were calculated for all groups. Safety was assessed after each dose in all participants. Results: All initially seronegative women became seropositive for both HPV 16 and 18 at Month 2. At Month 7, HPV-16 GMTs (95% CI) were 7908.4 (6874.0–9098.5) in 15–25 year olds, 4029.2 (3402.7–4771.0) in 26–45 year olds, and 2566.8 (2181.2–3020.6) in 46–55 year olds. For HPV-18, GMTs were 3499.3 (3098.7–3951.6) in 15–25 year olds, 1837.3 (1602.1–2107.0) in 26–45 year olds, and 1313.0 (1145.6–1504.9) in 46–55 year olds. Overall the vaccine was well-tolerated, and the incidence of local symptoms (within 30 days) tended to be lower in the 46–55 year-old group (69.2% versus 81.6% [26–45] and 85.7% [15–25]). Conclusions: An AS04-containing HPV-16/18 vaccine was immunogenic and generally safe in 15–55 year-old females. As observed with other vaccines, GMTs decreased with age, however, the Month 7 postvaccination antibody levels in the oldest age group (46–55) were still 3–4 times higher than those observed during a separate long-term follow-up study where sustained efficacy has been observed up to 48 months. [Table: see text]


Vaccine ◽  
1999 ◽  
Vol 17 (4) ◽  
pp. 369-372 ◽  
Author(s):  
Cho-Yu Chan ◽  
Shou-Dong Lee ◽  
May-Ing Yu ◽  
Yuan-Jen Wang ◽  
Full-Young Chang ◽  
...  

2008 ◽  
Vol 7 (2) ◽  
pp. 96-105 ◽  
Author(s):  
Kirsten D. Bentsen ◽  
KIM Hørslev-Petersen ◽  
Peter Junker ◽  
Erik Juhl ◽  
Ib Lorenzen ◽  
...  

2021 ◽  
Author(s):  
Bjørn Blomberg ◽  
Kristin Greve-Isdahl Mohn ◽  
Karl Albert Brokstad ◽  
Fan Zhou ◽  
Dagrun Waag Linchausen ◽  
...  

AbstractLong-term complications after coronavirus disease 2019 (COVID-19) are common in hospitalized patients, but the spectrum of symptoms in milder cases needs further investigation. We conducted a long-term follow-up in a prospective cohort study of 312 patients—247 home-isolated and 65 hospitalized—comprising 82% of total cases in Bergen during the first pandemic wave in Norway. At 6 months, 61% (189/312) of all patients had persistent symptoms, which were independently associated with severity of initial illness, increased convalescent antibody titers and pre-existing chronic lung disease. We found that 52% (32/61) of home-isolated young adults, aged 16–30 years, had symptoms at 6 months, including loss of taste and/or smell (28%, 17/61), fatigue (21%, 13/61), dyspnea (13%, 8/61), impaired concentration (13%, 8/61) and memory problems (11%, 7/61). Our findings that young, home-isolated adults with mild COVID-19 are at risk of long-lasting dyspnea and cognitive symptoms highlight the importance of infection control measures, such as vaccination.


2000 ◽  
Vol 118 (4) ◽  
pp. A1462
Author(s):  
Shou-Dong Lee ◽  
May-Ing Yu ◽  
Cho-Yu Chan ◽  
Yuan-Jen Wang ◽  
Full-Young Chang ◽  
...  

2019 ◽  
Vol 10 (3) ◽  
pp. e0020
Author(s):  
Halim Awadie ◽  
Johad Khoury ◽  
Yaniv Zohar ◽  
Afif Yaccob ◽  
Ella Veitsman ◽  
...  

2021 ◽  
Author(s):  
Chanukya GV ◽  
Aparna Srikantam

In COVID 19 pandemic, first line of defense is effective vaccination program. Because of multiple platforms available for vaccine production we tested relative immunogenicity of two vaccines available in India, Covaxin and Covishield We performed quantitative analysis of neutralizing antibodies to SARS Cov2 spike (receptor binding domain ) protein, from sera of 53 subjects who completed vaccines schedules. There was significantly higher immunogenic response with Covishield as compared to Covaxin and are independent of age. Studies on a large scale with long term follow up are needed to further advance the knowledge in this domain.


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