Asymmetric reduction of 2-oxo-4-phenylbutanoic acid ethyl ester by Daucus carota cell cultures

1996 ◽  
Vol 7 (6) ◽  
pp. 1571-1572 ◽  
Author(s):  
A. Chadha ◽  
M. Manohar ◽  
T. Soundararajan ◽  
T.S. Lokeswari
Keyword(s):  
Ethyl Ester ◽  
Cell Cultures ◽  
Daucus Carota ◽  
Asymmetric Reduction ◽  
Acid Ethyl Ester

ChemInform Abstract: Asymmetric Reduction of 2-Oxo-4-phenylbutanoic Acid Ethyl Ester by Daucus carota Cell Cultures.

ChemInform ◽  
2010 ◽  
Vol 27 (41) ◽  
pp. no-no
Author(s):  
A. CHADHA ◽  
M. MANOHAR ◽  
T. SOUNDARARAJAN ◽  
T. S. LOKESWARI
Keyword(s):  
Ethyl Ester ◽  
Cell Cultures ◽  
Daucus Carota ◽  
Asymmetric Reduction ◽  
Acid Ethyl Ester

Synthesis of (R)-(-)-Mandelic Acid Ethyl Ester by Asymmetric Reduction of Ethyl Benzoylformate with Yeast Cells

2012 ◽  
Vol 560-561 ◽  
pp. 273-278
Author(s):  
Zhi Min Ou ◽  
Ying Kang Nan
Keyword(s):  
Saccharomyces Cerevisiae ◽  
Ethyl Ester ◽  
Mandelic Acid ◽  
Cell Concentration ◽  
Asymmetric Reduction ◽  
Acid Ethyl Ester ◽  
Yeast Cells ◽  
Biotransformation Process ◽  
Set Up ◽  
Ethyl Benzoylformate

An efficient yeast cell biotransformation process was set up for asymmetric synthesis of (R)-(-)-mandelic acid ethyl ester, a key drug intermediate. Saccharomyces cerevisiae 21 was selected as optimum strain for biotransformation. The optimum reduction conditions are as follows: substrate concentration 20 g/L, cell concentration 140 g/L, reaction time 36 h, temperature 30 0C. Conversion and enantiometric excess of (R)-(-)-mandelic acid ethyl ester reached 99.8 % and 100%.

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