The Effects of Microelectrophoretically Applied Melatonin, Putative Transmitters, Thyroxine and Sex Hormones on the Electrical Activity of Pineal Cells in the Guinea-pig

Author(s):  
P. Semm ◽  
C. Demaine ◽  
L. Vollrath
1974 ◽  
Vol 61 (2) ◽  
pp. 255-263 ◽  
Author(s):  
D. G. PORTER ◽  
K. YOSHINAGA ◽  
J. FORD

SUMMARY The electrical activity of the myometrium and the intra-uterine pressure were recorded by means of suction electrodes and intraluminal balloons respectively from anaesthetized, oestrogen-primed, ovariectomized guinea-pigs treated with progesterone (25 mg, s.c. twice, 16 h apart). No loss of intra-uterine pressure occurred after progesterone treatment and electrical activities in the balloon-containing and intact horns were indistinguishable. Furthermore, the concentration of progesterone in the uteri of these animals was 0·32 ± 0·05 (S.E.M.) μg (balloon-containing horn) and 0·43 ± 0·06 μ/g wet tissue (intact horn). These values greatly exceed the levels found in uteri of pregnant animals (0·07 ± 0·03 μ/g wet tissue). Thus the failure of progesterone to reduce myometrial activity in the guinea-pig is real and is not due to interference from the balloon, or to failure of the steroid to reach the uterine muscle or to lack of oestrogen priming.


2007 ◽  
Vol 56 (2) ◽  
pp. e13
Author(s):  
Robert L. Hamlin ◽  
Anusak Kijtawornrat ◽  
Brian Roche ◽  
Jennifer Lolly ◽  
Jay Schmidt
Keyword(s):  

Pharmacology ◽  
1964 ◽  
Vol 11 (2) ◽  
pp. 119-127 ◽  
Author(s):  
R.M. Bergström ◽  
Lea Bergström ◽  
P. Putkonen ◽  
K. Sainio

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