THE TRANSDUCTION OF ENVIRONMENTAL LIGHTING CUES INTO BIOCHEMICAL RHYTHMS VIA MAMMALIAN PINEAL GLAND

Author(s):  
J.A. SMITH
1978 ◽  
Vol 76 (3) ◽  
pp. 547-548 ◽  
Author(s):  
M. D. ROLLAG ◽  
P. L. O'CALLAGHAN ◽  
G. D. NISWENDER

Department of Physiology and Biophysics, Colorado State University, Fort Collins, Colorado 80523, U.S.A. (Received 13 September 1977) Mammalian pineal gland activity is controlled by environmental lighting schedules. Light exerts its influence via a neuronal pathway originating in the retina (Moore & Klein, 1974) and as a consequence of this photoperiodic control, the concentration of melatonin in the plasma is raised during periods of darkness and depressed during periods of light (Rollag & Niswender, 1976). The response of the pineal gland to photostimulation is surprisingly rapid. Within 5 min of a darkness to light transition, there is a precipitous decline in pineal N-acetyltransferase activity in the rat (Deguchi & Axelrod, 1972; Klein & Weller, 1972). In sheep, peripheral concentrations of melatonin decline within 5–10 min of a darkness to light transition (Rollag, O'Callaghan & Niswender, 1978). A circadian rhythm of blood flow to the pineal gland analogous to the rhythm of melatonin


PLoS ONE ◽  
2018 ◽  
Vol 13 (10) ◽  
pp. e0205883 ◽  
Author(s):  
Joseph C. Mays ◽  
Michael C. Kelly ◽  
Steven L. Coon ◽  
Lynne Holtzclaw ◽  
Martin F. Rath ◽  
...  

1992 ◽  
Vol 21 (2) ◽  
pp. 136-157 ◽  
Author(s):  
Michal Karasek ◽  
Russel J. Reiter

Physiology ◽  
1991 ◽  
Vol 6 (5) ◽  
pp. 223-227 ◽  
Author(s):  
RJ Reiter

Circadian production and secretion of melatonin from mammalian pineal gland provides animals with information concerning the light/dark environment. Melatonin passes easily through cell membranes;thus each organ, provided it can interpret the melatonin message, can adjust its physiological activity accordingly.


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