ARE SPONTANEOUS AND ANTIBODY-DEPENDENT LYSIS TWO DIFFERENT MECHANISMS OF CYTOTOXICITY MEDIATED BY THE SAME CELL?**The experimental work described in this paper was supported by NIH grants CA-20833, CA-10815, CA-43882 and NS-11036 and by the National Multiple Sclerosis Society.

1980 ◽  
pp. 365-378 ◽  
Author(s):  
Bice Perussia ◽  
Daniela Santoli ◽  
Giorgio Trinchieri
Keyword(s):  
Multiple Sclerosis ◽  
Experimental Work ◽  
National Multiple Sclerosis Society

Revisiting The Multiple Sclerosis Functional Composite: proceedings from the National Multiple Sclerosis Society (NMSS) Task Force on Clinical Disability Measures

2012 ◽  
Vol 18 (8) ◽  
pp. 1074-1080 ◽  
Author(s):  
D Ontaneda ◽  
N LaRocca ◽  
T Coetzee ◽  
RA Rudick
Keyword(s):  
Multiple Sclerosis ◽  
Outcome Measure ◽  
Task Force ◽  
Critical Path ◽  
Washington Dc ◽  
Functional Composite ◽  
Multiple Sclerosis Functional Composite ◽  
Score Method ◽  
National Multiple Sclerosis Society ◽  
Disability Outcome

This article describes proceedings from a meeting of the National Multiple Sclerosis Society (NMSS) Task Force on Clinical Disability Measures (the TF). The TF was appointed by the NMSS Research Programs Advisory Committee with the goal of pooling and analyzing existing datasets to explore the utility of novel disability outcome measures based on the Multiple Sclerosis Functional Composite (MSFC) approach. The TF seeks to determine the suitability of the MSFC approach as a primary clinical outcome measure for registration trials in MS. The TF met in Washington, DC, Dec. 14 and 15, 2011, and provided unanimous support for a collaborative approach involving representatives from academic medicine, the pharmaceutical industry, regulatory agencies, the NMSS and the Critical Path Institute. There was also unanimous agreement that analysis of existing datasets would be useful in making progress toward the objective. The TF placed high value on determining the clinical meaning of individual component measures for the MSFC, and in establishing optimal analysis methods for MSFC so that scores would be more interpretable than the originally recommended z-score method. The background for a collaborative project aimed at developing an improved disability outcome measure is described in this paper.

Personal, health and function, and career maintenance factors as determinants of quality of life among employed people with multiple sclerosis

Work ◽  
2020 ◽  
Vol 67 (1) ◽  
pp. 81-94 ◽  
Author(s):  
Phillip Rumrill ◽  
Jian Li ◽  
David Strauser ◽  
Richard T. Roessler ◽  
Malachy Bishop ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Multiple Sclerosis ◽  
Multiple Regression Model ◽  
Future Research ◽  
Personal Health ◽  
Washington Dc ◽  
Perceived Quality Of Life ◽  
National Multiple Sclerosis Society ◽  
And Function

BACKGROUND: Multiple sclerosis (MS) is an intrusive disease that significantly affects labor force participation. OBJECTIVE: This study examined the extent to which factors at the personal, health and function, and environmental/career maintenance levels contribute to the predictability power for quality of life among employed people with MS. METHOD: Participants consisted of 523 members of nine National Multiple Sclerosis Society chapters representing 21 states and Washington, DC. These individuals were employed at the time of the survey, and they were primarily middle age (average age of 48 years) and Caucasian (74%). RESULTS: The final hierarchical multiple regression model explained 54 percent of the variability in participants’ quality of life scores, although none of the hypothesized personal/demographic predictors were significant. Participants who perceived better overall health and lower levels of stress, who experienced less severe cognitive and mobility-related MS symptoms, and who expressed stronger job-person matches and higher levels of job satisfaction reported higher quality of life scores than did other participants. CONCLUSIONS: The findings underscore the complexity involved in predicting perceived quality of life among employed people with MS. Implications of these findings for future research and clinical practice are discussed.

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