CHEMICALLY INDUCED GENE EXPRESSION: THE ROLE OF HISTONE HYPER-ACETYLATION IN TRANSFORMATION BY SV40 MINICHROMATIN  Supported by American Cancer Society Grant No. NP 123.

1979 ◽  
pp. 582
Author(s):  
Bennett N. Cohen ◽  
Thomas E. Wagner
Keyword(s):  
Gene Expression ◽  
American Cancer Society ◽  
Cancer Society ◽  
Chemically Induced

scholarly journals Inflammasome-derived cytokine IL18 suppresses amyloid-induced seizures in Alzheimer-prone mice

2018 ◽  
Vol 115 (36) ◽  
pp. 9002-9007 ◽  
Author(s):  
Te-Chen Tzeng ◽  
Yuto Hasegawa ◽  
Risa Iguchi ◽  
Amy Cheung ◽  
Daniel R. Caffrey ◽  
...  
Keyword(s):  
Gene Expression ◽  
Seizure Activity ◽  
Synaptic Proteins ◽  
Amyloid Peptide ◽  
Spine Density ◽  
Central Neurons ◽  
Chemically Induced ◽  
Neuronal Transmission ◽  
Selective Increase

Alzheimer’s disease (AD) is characterized by the progressive destruction and dysfunction of central neurons. AD patients commonly have unprovoked seizures compared with age-matched controls. Amyloid peptide-related inflammation is thought to be an important aspect of AD pathogenesis. We previously reported that NLRP3 inflammasome KO mice, when bred into APPswe/PS1ΔE9 (APP/PS1) mice, are completely protected from amyloid-induced AD-like disease, presumably because they cannot produce mature IL1β or IL18. To test the role of IL18, we bred IL18KO mice with APP/PS1 mice. Surprisingly, IL18KO/APP/PS1 mice developed a lethal seizure disorder that was completely reversed by the anticonvulsant levetiracetam. IL18-deficient AD mice showed a lower threshold in chemically induced seizures and a selective increase in gene expression related to increased neuronal activity. IL18-deficient AD mice exhibited increased excitatory synaptic proteins, spine density, and basal excitatory synaptic transmission that contributed to seizure activity. This study identifies a role for IL18 in suppressing aberrant neuronal transmission in AD.

Inside Magoo (1960): Comedic Commentary on 1950s America and Cancer

2020 ◽  
Author(s):  
David Cantor
Keyword(s):  
Middle Class ◽  
White Male ◽  
American Cancer Society ◽  
Educational Film ◽  
Cancer Society ◽  
The 1950S ◽  
Post War ◽  
United Productions Of America

This chapter traces the role of humour in Inside Magoo (1960), an educational film released by United Productions of America (UPA) for the American Cancer Society (ACS). Humour, I suggest, provided 1) a response to ACS’s concerns that public fears of cancer led people to avoid appropriate medical help, and 2) a commentary on 1950s America from the perspective of someone – Mr. Magoo – who rejected the post-war world of white, male, middle-class, consumerist suburbia. This film was thus not only about cancer. It wrapped the ACS message within humorous observations on life in the 1950s to charm audiences into adopting ACS approaches to the disease; a technique, I suggest, that was common to other UPA cancer educationals of the 1950s.

The shifting tobacco paradigm and the role of the American Cancer Society

2000 ◽  
pp. 796-797
Author(s):  
D. G. Bal ◽  
J. Cook ◽  
R. Todd ◽  
M. Morra ◽  
N. Lins ◽  
...  
Keyword(s):  
American Cancer Society ◽  
Cancer Society
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