Gold nanoparticles for cancer diagnostics, spectroscopic imaging, drug delivery, and plasmonic photothermal therapy

The diverse behavior of nanogold in the therapeutic field is related to its unique size and shape. Nanogold offers improvements in modern diagnostic and therapeutic implications, increases disease specificity and targeted drug delivery, and is relatively economical compared with other chemotherapeutic protocols. The diagnosis of cancer and photothermal therapy improve drastically with the implementation of nanotechnology. Different types of nanoparticles, that is, gold silica nanoshells, nanorods and nanospheres of diverse shapes and geometries, are used widely in the photothermal therapy of cancerous cells and nodules. Numerous reviews have been published on the therapeutic applications of gold nanoparticles, but studies on combinatorial applications of nanogold in cancer therapy are limited. This review focuses on the combinatorial cancer therapy using optical properties of nanogold with different shapes and geometries, and their therapeutic applications in cancer diagnosis, photothermal therapy, cancer imaging and targeted drug delivery.

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Plasmonic photothermal therapy (PPTT) using gold nanoparticles

Lasers in Medical Science ◽

10.1007/s10103-007-0470-x ◽

2007 ◽

Vol 23 (3) ◽

pp. 217-228 ◽

Cited By ~ 1361

Author(s):

Xiaohua Huang ◽

Prashant K. Jain ◽

Ivan H. El-Sayed ◽

Mostafa A. El-Sayed

Keyword(s):

Gold Nanoparticles ◽

Photothermal Therapy ◽

Plasmonic Photothermal Therapy

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Effects of macrophage polarization on gold nanoparticle-assisted plasmonic photothermal therapy

RSC Advances ◽

10.1039/d1ra03671h ◽

2021 ◽

Vol 11 (40) ◽

pp. 25047-25056

Author(s):

Hala R. Ali ◽

Salah A. Selim ◽

Daniel Aili

Keyword(s):

Gold Nanoparticles ◽

Laser Irradiation ◽

Gold Nanoparticle ◽

Photothermal Therapy ◽

Macrophage Polarization ◽

Preferential Uptake ◽

M2 Phenotype ◽

Plasmonic Photothermal Therapy

A preferential uptake of gold nanoparticles by macrophages with a protumoral M2 phenotype result in efficient killing upon laser irradiation while keeping M1 phenotypes relatively undamaged.

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Conjugated anisotropic gold nanoparticles through pterin derivatives for a selective plasmonic photothermal therapy: in vitro studies in HeLa and normal human endocervical cells

Gold Bulletin ◽

10.1007/s13404-020-00288-9 ◽

2021 ◽

Author(s):

Diana Blach ◽

Carlos E. Alves De Souza ◽

Stelia C. Méndez ◽

Fernando O. Martínez

Keyword(s):

Gold Nanoparticles ◽

Photothermal Therapy ◽

In Vitro Studies ◽

Normal Human ◽

Anisotropic Gold Nanoparticles ◽

Plasmonic Photothermal Therapy

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Assessment and Modeling of Plasmonic Photothermal Therapy Delivered via a Fiberoptic Microneedle Device Ex Vivo

Pharmaceutics ◽

10.3390/pharmaceutics13122133 ◽

2021 ◽

Vol 13 (12) ◽

pp. 2133

Author(s):

Forhad Akhter ◽

Santiago Manrique-Bedoya ◽

Chris Moreau ◽

Andrea Lynn Smith ◽

Yusheng Feng ◽

...

Keyword(s):

Pancreatic Cancer ◽

Gold Nanoparticles ◽

Photothermal Therapy ◽

Ex Vivo ◽

Temperature Shift ◽

Photon Absorption ◽

Tissue Temperature ◽

Selective Treatment ◽

Porcine Pancreas ◽

Plasmonic Photothermal Therapy

Plasmonic photothermal therapy (PPTT) has potential as a superior treatment method for pancreatic cancer, a disease with high mortality partially attributable to the currently non-selective treatment options. PPTT utilizes gold nanoparticles infused into a targeted tissue volume and exposed to a specific light wavelength to induce selective hyperthermia. The current study focuses on developing this approach within an ex vivo porcine pancreas model via an innovative fiberoptic microneedle device (FMD) for co-delivering light and gold nanoparticles. The effects of laser wavelengths (808 vs. 1064 nm), irradiances (20–50 mW·mm−2), and gold nanorod (GNR) concentrations (0.1–3 nM) on tissue temperature profiles were evaluated to assess and control hyperthermic generation. The GNRs had a peak absorbance at ~800 nm. Results showed that, at 808 nm, photon absorption and subsequent heat generation within tissue without GNRs was 65% less than 1064 nm. The combination of GNRs and 808 nm resulted in a 200% higher temperature rise than the 1064 nm under similar conditions. A computational model was developed to predict the temperature shift and was validated against experimental results with a deviation of <5%. These results show promise for both a predictive model and spatially selective, tunable treatment modality for pancreatic cancer.

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