In situ gelling systems of chitosan for potential drug delivery applications

2022 ◽  
pp. 195-224
Author(s):  
Sabya Sachi Das ◽  
Priyanshu Bharadwaj ◽  
Sandeep Kumar Singh ◽  
P.R.P. Verma ◽  
Sarwar Beg
Keyword(s):  
Drug Delivery ◽  
Potential Drug ◽  
Drug Delivery Applications ◽  
In Situ Gelling

scholarly journals Poloxamer-based in situ gelling thermoresponsive systems for ocular drug delivery applications

2019 ◽  
Vol 24 (8) ◽  
pp. 1575-1586 ◽  
Author(s):  
Karim A. Soliman ◽  
K Ullah ◽  
A. Shah ◽  
David S. Jones ◽  
Thakur R.R. Singh
Keyword(s):  
Drug Delivery ◽  
Ocular Drug Delivery ◽  
Drug Delivery Applications ◽  
In Situ Gelling

Synthesis and self-assembly behaviour of poly(Nα-Boc-l-tryptophan)-block-poly(ethylene glycol)-block-poly(Nα-Boc-l-tryptophan)

RSC Advances ◽  
2016 ◽  
Vol 6 (29) ◽  
pp. 24142-24153
Author(s):  
Andreea S. Voda ◽  
Kevin Magniez ◽  
Nisa V. Salim ◽  
Cynthia Wong ◽  
Qipeng Guo
Keyword(s):  
Drug Delivery ◽  
Ethylene Glycol ◽  
Self Assembly ◽  
Triblock Copolymers ◽  
Potential Drug ◽  
Poly Ethylene Glycol ◽  
Drug Delivery Applications ◽  
Poly Ethylene ◽  
First Time

We report for the first time the use of Nα-Boc-l-tryptophan for the synthesis of amphiphilic BAB triblock copolymers for potential drug delivery applications.

Synthesis and Characterization of pH-Sensitive Biodegradable Polyurethane for Potential Drug Delivery Applications

2011 ◽  
Vol 44 (4) ◽  
pp. 857-864 ◽  
Author(s):  
Lijuan Zhou ◽  
Lunquan Yu ◽  
Mingming Ding ◽  
Jiehua Li ◽  
Hong Tan ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Ph Sensitive ◽  
Synthesis And Characterization ◽  
Potential Drug ◽  
Biodegradable Polyurethane ◽  
Drug Delivery Applications

scholarly journals In-vivo Evaluation and Characterization of Novel In-Situ Gelling System as Controlled Delivery System Containing Ciprofloxacin for Ocular Drug Delivery

2020 ◽  
Vol 10 (5-s) ◽  
pp. 32-39
Author(s):  
Fatima Eram ◽  
, Vivek
Keyword(s):  
Drug Delivery ◽  
Delivery System ◽  
Average Concentration ◽  
Posterior Segment ◽  
Ocular Infection ◽  
In Vivo Evaluation ◽  
Micro Emulsion ◽  
In Situ Gelling

Objectives: The purpose of this research was to develop the micro emulsion-based in situ gelling systems containing Ciprofloxacin for prophylaxis and treatment of the posterior segment diseases like endophthalmitis. Methods: Ciprofloxacin was encapsulated in small droplets owing to form microemulsion, and then the formed droplets were dispersed in a polymer solution that converted into a gel upon triggered by the electrolyte present in the tear fluid. Results: The formulation approach provides better absorption, penetration, retention, and improves the bioavailability of the drug. The average concentration reached into vitreous humor from topical microemulsion in situ gelling formulation was ~0.4 µg/ml, which is far more than the concentration required for therapeutic effect (i.e.  >0.047 µg/ml or >MIC90 for S. Epidermidis, a pathogen commonly responsible to cause endophthalmitis). Conclusion: Thus, novel micro emulsion-based in situ gelling formulation could be a potential drug delivery system for the treatment of posterior segment diseases like endophthalmitis. Keywords: Microemulsion, ciprofloxacin, endophthalmitis, ocular, infection, in situ

Design of interpenetrating chitosan and poly(ethylene glycol) sponges for potential drug delivery applications

2017 ◽  
Vol 170 ◽  
pp. 166-175 ◽  
Author(s):  
Lisa Racine ◽  
Guillaume Costa ◽  
Eric Bayma-Pecit ◽  
Isabelle Texier ◽  
Rachel Auzély-Velty
Keyword(s):  
Drug Delivery ◽  
Ethylene Glycol ◽  
Potential Drug ◽  
Poly Ethylene Glycol ◽  
Drug Delivery Applications ◽  
Poly Ethylene

scholarly journals Thermosensitive PEG–PCL–PEG (PECE) hydrogel as an in situ gelling system for ocular drug delivery of diclofenac sodium

Drug Delivery ◽  
2014 ◽  
Vol 23 (1) ◽  
pp. 63-68 ◽  
Author(s):  
Zichao Luo ◽  
Ling Jin ◽  
Lu Xu ◽  
Zhao Liang Zhang ◽  
Jing Yu ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Diclofenac Sodium ◽  
Ocular Drug Delivery ◽  
In Situ Gelling

Carrageenan: A Wonder Polymer from Marine Algae for Potential Drug Delivery Applications

2019 ◽  
Vol 25 (11) ◽  
pp. 1172-1186 ◽  
Author(s):  
Dilshad Qureshi ◽  
Suraj Kumar Nayak ◽  
Samarendra Maji ◽  
Doman Kim ◽  
Indranil Banerjee ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Biological Activities ◽  
Medical Science ◽  
Drug Carriers ◽  
Sulfated Polysaccharides ◽  
Potential Drug ◽  
Natural Polymers ◽  
Structural Variations ◽  
Varied Range ◽  
Drug Delivery Applications

Background: With the advancement in the field of medical science, the idea of sustained release of the therapeutic agents in the patient’s body has remained a major thrust for developing advanced drug delivery systems (DDSs). The critical requirement for fabricating these DDSs is to facilitate the delivery of their cargos in a spatio-temporal and pharmacokinetically-controlled manner. Albeit the synthetic polymer-based DDSs normally address the above-mentioned conditions, their potential cytotoxicity and high cost have ultimately constrained their success. Consequently, the utilization of natural polymers for the fabrication of tunable DDSs owing to their biocompatible, biodegradable, and non-toxic nature can be regarded as a significant stride in the field of drug delivery. Marine environment serves as an untapped resource of varied range of materials such as polysaccharides, which can easily be utilized for developing various DDSs. Methods: Carrageenans are the sulfated polysaccharides that are extracted from the cell wall of red seaweeds. They exhibit an assimilation of various biological activities such as anti-thrombotic, anti-viral, anticancer, and immunomodulatory properties. The main aim of the presented review is threefold. The first one is to describe the unique physicochemical properties and structural composition of different types of carrageenans. The second is to illustrate the preparation methods of the different carrageenan-based macro- and micro-dimensional DDSs like hydrogels, microparticles, and microspheres respectively. Fabrication techniques of some advanced DDSs such as floating hydrogels, aerogels, and 3-D printed hydrogels have also been discussed in this review. Next, considerable attention has been paid to list down the recent applications of carrageenan-based polymeric architectures in the field of drug delivery. Results: Presence of structural variations among the different carrageenan types helps in regulating their temperature and ion-dependent sol-to-gel transition behavior. The constraint of low mechanical strength of reversible gels can be easily eradicated using chemical crosslinking techniques. Carrageenan based-microdimesional DDSs (e.g. microspheres, microparticles) can be utilized for easy and controlled drug administration. Moreover, carrageenans can be fabricated as 3-D printed hydrogels, floating hydrogels, and aerogels for controlled drug delivery applications. Conclusion: In order to address the problems associated with many of the available DDSs, carrageenans are establishing their worth recently as potential drug carriers owing to their varied range of properties. Different architectures of carrageenans are currently being explored as advanced DDSs. In the near future, translation of carrageenan-based advanced DDSs in the clinical applications seems inevitable.

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