Null Cell Adenoma

2018 ◽  
pp. 578-579
Author(s):  
Vania Nosé
Keyword(s):  
Null Cell ◽  
Cell Adenoma ◽  
Null Cell Adenoma

Ultrastructural Classification of Pituary Adenomas

1990 ◽  
Vol 48 (3) ◽  
pp. 258-258
Author(s):  
S. Arumugam ◽  
Sarasa Bharati Arumugam
Keyword(s):  
Cytoplasmic Organelle ◽  
Null Cell ◽  
Cell Adenoma ◽  
Mixed Cell ◽  
Light Microscope Level ◽  
Null Cell Adenoma ◽  
Growth Hormone Cell ◽  
Ultrastructural Characteristics ◽  
Organelle Morphology

Adenoaas of the pituitary are no longer classified based on their tinctorial affinity to dyes. With the advent of the newer methods of sophisticated technology, it is now possible to classify. These depending upon the type of hormone secreted based either on histochemical techniques or on ultrastructural characteristics. The latter provides an insight into the cytoplasmic organelle morphology which offers a delightful feast to the eye as well.This paper presents the ultrastructural characters of the pituitary adenoma as seen in Madras. 171 adenomas (124 males and 47 females) were seen during 1972-1989, classified at the light microscope level as 159 chromophobe, 2 basophilic, 4 eosinophilic and 6 mixed adenomas.Ultrastructural examination showed that the sparsely granular prolactin cell adenoma is the commonest adenoma to be encountered closely followed by the growth hormone cell adenoma, null cell adenoma, the mixed cell adenoma and others.

Le macroadénome hypophysaire non fonctionnel immunonégatif « null cell adenoma » : à propos d’un cas

2017 ◽  
Vol 78 (4) ◽  
pp. 314
Author(s):  
I. Bayar ◽  
Y. Hasni ◽  
A. Ben Abdelkrim ◽  
M. Kacem ◽  
M. Chaieb ◽  
...  
Keyword(s):  
Null Cell ◽  
Cell Adenoma ◽  
Null Cell Adenoma

Atypical pituitary adenomas: incidence, clinical characteristics, and implications

2011 ◽  
Vol 114 (2) ◽  
pp. 336-344 ◽  
Author(s):  
Gabriel Zada ◽  
Whitney W. Woodmansee ◽  
Shakti Ramkissoon ◽  
Jordan Amadio ◽  
Vania Nose ◽  
...  
Keyword(s):  
Pituitary Adenomas ◽  
Immunohistochemical Analysis ◽  
Null Cell ◽  
Cell Adenoma ◽  
Null Cell Adenoma ◽  
Tumor Subtypes ◽  
P53 Immunoreactivity ◽  
Mib 1

Object The 2004 WHO classification of pituitary adenomas now includes an “atypical” variant, defined as follows: MIB-1 proliferative index greater than 3%, excessive p53 immunoreactivity, and increased mitotic activity. The authors review the incidence of this atypical histopathological subtype and its correlation with tumor subtype, invasion, and surgical features. Methods The records of 121 consecutive patients who underwent transsphenoidal surgery for pituitary adenomas during an 18-month period were retrospectively reviewed for evidence of atypical adenomas. Results Eighteen adenomas (15%) met the criteria for atypical lesions; 17 (94%) of the 18 were macroadenomas. On imaging, 15 (83%) demonstrated imaging evidence of surrounding invasion, compared with 45% of typical adenomas (p = 0.004). Atypical tumors occurred in 12 female (67%) and 6 male (33%) patients. Patient age ranged from 16 to 70 years (mean 48 years). Nine patients (50%) had hormonally active tumors, and 9 had nonfunctional lesions. Four (22%) of the 18 patients presented to us with recurrent tumors. Immunohistochemical analysis demonstrated the following tumor subtypes: GH-secreting adenoma with plurihormonal staining (5 patients [28%]); null-cell adenoma (5 patients [28%]); silent ACTH tumor (3 patients [17%]), ACTH-staining tumor with Cushing's disease (2 patients [11%]), prolactinoma (2 patients [11%]), and silent FSH-staining tumor (1 patient [6%]). The MIB-1 labeling index ranged from 3% to 20% (mean 7%). Conclusions Atypical tumors were identified in 15% of resected pituitary adenomas, and they tended to be aggressive, invasive macroadenomas. More longitudinal follow-up is required to determine whether surgical outcomes, potential for recurrence, or metastasis of atypical adenomas vary significantly from their typical counterparts.

Null Cell Adenoma of the Pituitary Gland

1991 ◽  
Vol 84 (10) ◽  
pp. 1239-1242 ◽  
Author(s):  
JOSEPH C. CHAO ◽  
CESAR V. REYES ◽  
MUMTAZ CHINOY
Keyword(s):  
Pituitary Gland ◽  
Null Cell ◽  
Cell Adenoma ◽  
Null Cell Adenoma

Pituitary Null Cell Adenoma in a Domestic Llama (Lama glama)

2014 ◽  
Vol 151 (1) ◽  
pp. 51-56 ◽  
Author(s):  
M.D. Chalkley ◽  
M. Kiupel ◽  
A.C.E. Draper
Keyword(s):  
Null Cell ◽  
Cell Adenoma ◽  
Null Cell Adenoma ◽  
Lama Glama

scholarly journals Identification of a subtype-specific ENC1 gene related to invasiveness in human pituitary null cell adenoma and oncocytomas

2014 ◽  
Vol 119 (2) ◽  
pp. 307-315 ◽  
Author(s):  
Jie Feng ◽  
Lichuan Hong ◽  
Yonggang Wu ◽  
Chuzhong Li ◽  
Hong Wan ◽  
...  
Keyword(s):  
Null Cell ◽  
Human Pituitary ◽  
Cell Adenoma ◽  
Null Cell Adenoma

scholarly journals Null Cell Adenoma of the Pituitary: Pseudo-rosettes Say It Best When Immunohistochemistry Says Nothing At All!

2018 ◽  
Vol 13 (4) ◽  
pp. 677-680
Author(s):  
Vikram Singh ◽  
Kirti Gupta ◽  
Pravin Salunke ◽  
Sivashanmugam S. Dhandapani
Keyword(s):  
Null Cell ◽  
Cell Adenoma ◽  
Null Cell Adenoma
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