Atomically precise fluorescent metal nanoclusters

2022 ◽  
pp. 207-242
Author(s):  
Shilpa Bothra ◽  
Suban K. Sahoo
Keyword(s):  
Metal Nanoclusters

Simulation of Spherical Metal Nanoclusters Containing Monovacancy

2019 ◽  
Vol 11 (5) ◽  
pp. 05018-1-05018-8
Author(s):  
V. I. Reva ◽  
◽  
O. V. Vasylenko ◽  
V. V. Pogosov ◽  
◽  
...  
Keyword(s):  
Metal Nanoclusters

Detection of Glucose in Human Serum Based on Silicon Dot Probe

2020 ◽  
Vol 16 (6) ◽  
pp. 744-752
Author(s):  
Kuan Luo ◽  
Xinyu Jiang
Keyword(s):  
Quantum Dots ◽  
Blood Glucose ◽  
Human Serum ◽  
Organic Dyes ◽  
Limit Of Detection ◽  
Fasting Blood Glucose ◽  
Glucose Biosensor ◽  
Metal Nanoclusters ◽  
Glucose Levels ◽  
Highly Sensitive

Background: Diabetes Mellitus (DM) is a major public metabolic disease that influences 366 million people in the world in 2011, and this number is predicted to rise to 552 million in 2030. DM is clinically diagnosed by a fasting blood glucose that is equal or greater than 7 mM. Therefore, the development of effective glucose biosensor has attracted extensive attention worldwide. Fluorescence- based strategies have sparked tremendous interest due to their rapid response, facile operation, and excellent sensitivity. Many fluorescent compounds have been employed for precise analysis of glucose, including quantum dots, noble metal nanoclusters, up-converting nanoparticles, organic dyes, and composite fluorescent microspheres. Silicon dot as promising quantum dots materials have received extensive attention, owing to their distinct advantages such as biocompatibility, low toxicity and high photostability. Methods: MnO2 nanosheets on the Si nanoparticles (NPs) surface serve as a quencher. Si NPs fluorescence can make a recovery by the addition of H2O2, which can reduce MnO2 to Mn2+, and the glucose can thus be monitored based on the enzymatic conversion of glucose by glucose oxidase to generate H2O2. Therefore, the glucose concentration can be derived by recording the fluorescence recovery spectra of the Si NPs. Results: This probe enabled selective detection of glucose with a linear range of 1-100 μg/mL and a limit of detection of 0.98 μg/mL. Compared with the commercial glucometer, this method showed favorable results and convincing reliability. Conclusion: We have developed a novel method based on MnO2 -nanosheet-modified Si NPs for rapid monitoring of blood glucose levels. By combining the highly sensitive H2O2/MnO2 reaction with the excellent photostability of Si NPs, a highly sensitive, selective, and cost-efficient sensing approach for glucose detection has been designed and applied to monitor glucose levels in human serum with satisfactory results.

Molecular dynamics investigation of the size dependence of the heat of melting of metal nanoclusters

2014 ◽  
Vol 56 (12) ◽  
pp. 2369-2373 ◽  
Author(s):  
V. M. Samsonov ◽  
S. A. Vasilyev ◽  
A. G. Bembel ◽  
T. E. Samsonov ◽  
V. L. Skopich
Keyword(s):  
Molecular Dynamics ◽  
Size Dependence ◽  
Metal Nanoclusters

Thiolate‐Protected Metal Nanoclusters: Recent Development in Synthesis, Understanding of Reaction, and Application in Energy and Environmental Field

Small ◽  
2021 ◽  
pp. 2005328
Author(s):  
Tokuhisa Kawawaki ◽  
Ayano Ebina ◽  
Yasunaga Hosokawa ◽  
Shuhei Ozaki ◽  
Daiki Suzuki ◽  
...  
Keyword(s):  
Metal Nanoclusters

Protein-protected metal nanoclusters as diagnostic and therapeutic platforms for biomedical applications

2021 ◽  
Author(s):  
Iman Zare ◽  
Daniel M. Chevrier ◽  
Anna Cifuentes-Rius ◽  
Nasrin Moradi ◽  
Yunlei Xianyu ◽  
...  
Keyword(s):  
Biomedical Applications ◽  
Metal Nanoclusters

A New Strategy to Construct Gold Nanoclusters-Based Optical Probe Using Luminescence Resonance Energy Transfer

2021 ◽  
Author(s):  
Shuyang Zhai ◽  
Wei Hu ◽  
Chen Fan ◽  
Wenqi Feng ◽  
Zhi-hong Liu
Keyword(s):  
Energy Transfer ◽  
Gold Nanoclusters ◽  
Resonance Energy Transfer ◽  
Resonance Energy ◽  
Optical Probe ◽  
Luminescent Materials ◽  
Metal Nanoclusters ◽  
New Strategy ◽  
Photoluminescence Efficiency

Monolayer-protected metal nanoclusters (MPCs) are emerging as intriguing luminescent materials, but the construction of MPCs-based optical probe is still scarce because of both the limited photoluminescence efficiency of MPCs and...

scholarly journals Synthesis of Exosome-Based Fluorescent Gold Nanoclusters for Cellular Imaging Applications

2021 ◽  
Vol 22 (9) ◽  
pp. 4433
Author(s):  
Eun Sung Lee ◽  
Byung Seok Cha ◽  
Seokjoon Kim ◽  
Ki Soo Park
Keyword(s):  
Photoelectron Spectroscopy ◽  
Low Cost ◽  
Stokes Shift ◽  
Gold Nanoclusters ◽  
Human Colon ◽  
Cellular Imaging ◽  
Metal Nanoclusters ◽  
Human Colon Cancer ◽  
X Ray ◽  
High Concentrations

In recent years, fluorescent metal nanoclusters have been used to develop bioimaging and sensing technology. Notably, protein-templated fluorescent gold nanoclusters (AuNCs) are attracting interest due to their excellent fluorescence properties and biocompatibility. Herein, we used an exosome template to synthesize AuNCs in an eco-friendly manner that required neither harsh conditions nor toxic chemicals. Specifically, we used a neutral (pH 7) and alkaline (pH 11.5) pH to synthesize two different exosome-based AuNCs (exo-AuNCs) with independent blue and red emission. Using field-emission scanning electron microscopy, energy dispersive X-ray microanalysis, nanoparticle tracking analysis, and X-ray photoelectron spectroscopy, we demonstrated that AuNCs were successfully formed in the exosomes. Red-emitting exo-AuNCs were found to have a larger Stokes shift and a stronger fluorescence intensity than the blue-emitting exo-AuNCs. Both exo-AuNCs were compatible with MCF-7 (human breast cancer), HeLa (human cervical cancer), and HT29 (human colon cancer) cells, although blue-emitting exo-AuNCs were cytotoxic at high concentrations (≥5 mg/mL). Red-emitting exo-AuNCs successfully stained the nucleus and were compatible with membrane-staining dyes. This is the first study to use exosomes to synthesize fluorescent nanomaterials for cellular imaging applications. As exosomes are naturally produced via secretion from almost all types of cell, the proposed method could serve as a strategy for low-cost production of versatile nanomaterials.

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