New Insights into Epithelial Cell Function in Mucosal Immunity

1996 ◽  
pp. 141-149 ◽  
Author(s):  
Michael E. Lamm ◽  
John G. Nedrud ◽  
Charlotte S. Kaetzel ◽  
Mary B. Mazanec
Keyword(s):  
Epithelial Cell ◽  
Mucosal Immunity ◽  
Cell Function

II. One size fits all: nonclassical MHC molecules fulfill multiple roles in epithelial cell function

1998 ◽  
Vol 274 (2) ◽  
pp. G227-G231 ◽  
Author(s):  
Richard S. Blumberg
Keyword(s):  
Epithelial Cell ◽  
Mhc Class I ◽  
Cell Biology ◽  
Cell Function ◽  
Surface Glycoprotein ◽  
Class I ◽  
Human Major Histocompatibility Complex ◽  
Cell Surface Glycoprotein ◽  
Mhc Molecules ◽  
Nonclassical Mhc

The human major histocompatibility complex (MHC) on chromosome 6 encodes three classical class I genes: human leukocyte antigen-A (HLA-A), HLA-B, and HLA-C. These polymorphic genes encode a 43- to 45-kDa cell surface glycoprotein that, in association with the 12-kDa β2-microglobulin molecule, functions in the presentation of nine amino acid peptides to the T cell receptor of CD8-bearing T lymphocytes and killer inhibitory receptors on natural killer cells. In addition to these ubiquitously expressed polymorphic proteins, the human genome also encodes a number of nonclassical MHC class I-like, or class Ib, genes that in general encode nonpolymorphic molecules involved in a variety of specific immunologic functions. Many of these genes, including CD1, the neonatal Fc receptor for immunoglobulin G, HLA-G, the MHC class I chain-related gene A, and Hfe, are prominently displayed on epithelial cells, suggesting an important role in epithelial cell biology.

scholarly journals Pulmonary Epithelial Cell-Derived Cytokine TGF-β1 Is a Critical Cofactor for Enhanced Innate Lymphoid Cell Function

Immunity ◽  
2015 ◽  
Vol 43 (5) ◽  
pp. 945-958 ◽  
Author(s):  
Laura Denney ◽  
Adam J. Byrne ◽  
Thomas J. Shea ◽  
James S. Buckley ◽  
James E. Pease ◽  
...  
Keyword(s):  
Epithelial Cell ◽  
Lymphoid Cell ◽  
Cell Function ◽  
Innate Lymphoid Cell ◽  
Pulmonary Epithelial Cell ◽  
Tgf Β1

Modulation of Epithelial Cell Function by Glucocorticoids: Anti-Inflammatory and Other Effects

2008 ◽  
pp. 367-390
Author(s):  
Robert Newton ◽  
Manminder Kaur ◽  
Elizabeth M. King ◽  
Wei Gong ◽  
Donna M. Slater ◽  
...  
Keyword(s):  
Epithelial Cell ◽  
Cell Function ◽  
Anti Inflammatory

Carbon Monoxide Reversibly Alters Iron Homeostasis and Respiratory Epithelial Cell Function

2008 ◽  
Vol 38 (6) ◽  
pp. 715-723 ◽  
Author(s):  
Andrew J. Ghio ◽  
Jacqueline G. Stonehuerner ◽  
Lisa A. Dailey ◽  
Judy H. Richards ◽  
Michael D. Madden ◽  
...  
Keyword(s):  
Carbon Monoxide ◽  
Epithelial Cell ◽  
Iron Homeostasis ◽  
Cell Function ◽  
Respiratory Epithelial Cell ◽  
Respiratory Epithelial

scholarly journals Translocation of verotoxin-1 across T84 monolayers: mechanism of bacterial toxin penetration of epithelium

1997 ◽  
Vol 273 (6) ◽  
pp. G1349-G1358 ◽  
Author(s):  
Dana J. Philpott ◽  
Cameron A. Ackerley ◽  
Amanda J. Kiliaan ◽  
Mohamed A. Karmali ◽  
Mary H. Perdue ◽  
...  
Keyword(s):  
Epithelial Cell ◽  
Barrier Function ◽  
Pathogenic Bacteria ◽  
Intestinal Epithelial Cell ◽  
Cell Function ◽  
Bacterial Toxin ◽  
General Mechanism ◽  
Epithelial Cell Line ◽  
Intestinal Epithelial ◽  
T84 Cells

Verotoxin-producing Escherichia coli (VTEC) are pathogenic bacteria associated with diarrhea, hemorrhagic colitis, and hemolytic uremic syndrome. Verotoxins (VTs) elaborated by these organisms produce cytopathic effects on a restricted number of cell types, including endothelial cells lining the microvasculature of the bowel and the kidney. Because human intestinal epithelial cells lack the globotriaosylceramide receptor for VT binding, it is unclear how the toxin moves across the intestinal mucosa to the systemic circulation. The aims of this study were to determine the effects of VT-1 on intestinal epithelial cell function and to characterize VT-1 translocation across monolayers of T84 cells, an intestinal epithelial cell line. VT-1 at concentrations up to 1 μg/ml had no effect on the barrier function of T84 monolayers as assessed by measuring transmonolayer electrical resistance (102 ± 8% of control monolayers). In contrast, both VT-positive and VT-negative VTEC bacterial strains lowered T84 transmonolayer resistance (45 ± 7 and 38 ± 6% of controls, respectively). Comparable amounts of toxin moved across monolayers of T84 cells, exhibiting high-resistance values, as monolayers with VTEC-induced decreases in barrier function, suggesting a transcellular mode of transport. Translocation of VT-1 across T84 monolayers paralleled the movement of a comparably sized protein, horseradish peroxidase. Immunoelectron microscopy confirmed transcellular transport of VT-1, since the toxin was observed within endosomes and associated with specific intracellular targets, including the Golgi network and endoplasmic reticulum. These data present a mode of VT-1 uptake by toxin-insensitive cells and suggest a general mechanism by which bacterial toxins lacking specific intestinal receptors can penetrate the intestinal epithelial barrier.

scholarly journals CRAC channels in secretory epithelial cell function and disease

Cell Calcium ◽  
2019 ◽  
Vol 78 ◽  
pp. 48-55 ◽  
Author(s):  
Haiping Liu ◽  
Ahmed Kabrah ◽  
Malini Ahuja ◽  
Shmuel Muallem
Keyword(s):  
Epithelial Cell ◽  
Cell Function ◽  
Crac Channels ◽  
Secretory Epithelial Cell
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