scholarly journals Creation of a blood-compatible surface: A novel strategy for suppressing blood activation and coagulation using a nitroxide radical-containing polymer with reactive oxygen species scavenging activity

2012 ◽  
Vol 8 (3) ◽  
pp. 1323-1329 ◽  
Author(s):  
Toru Yoshitomi ◽  
Yu Yamaguchi ◽  
Akihiko Kikuchi ◽  
Yukio Nagasaki
Keyword(s):  
Reactive Oxygen Species ◽  
Reactive Oxygen ◽  
Nitroxide Radical ◽  
Scavenging Activity ◽  
Oxygen Species ◽  
Novel Strategy

Scavenging activity of indole compounds against cisplatin-induced reactive oxygen species

Life Sciences ◽  
2006 ◽  
Vol 80 (3) ◽  
pp. 254-257 ◽  
Author(s):  
Junya Fukutomi ◽  
Atsushi Fukuda ◽  
Satoshi Fukuda ◽  
Masayuki Hara ◽  
Atsushi Terada ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Reactive Oxygen ◽  
Scavenging Activity ◽  
Oxygen Species ◽  
Indole Compounds

scholarly journals Increased levels of thiols protect antimony unresponsive Leishmania donovani field isolates against reactive oxygen species generated by trivalent antimony

Parasitology ◽  
2007 ◽  
Vol 134 (12) ◽  
pp. 1679-1687 ◽  
Author(s):  
G. MANDAL ◽  
S. WYLLIE ◽  
N. SINGH ◽  
S. SUNDAR ◽  
A. H. FAIRLAMB ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Leishmania Donovani ◽  
Indian Subcontinent ◽  
Current Trend ◽  
Reactive Oxygen ◽  
Clinical Isolates ◽  
Ros Generation ◽  
Scavenging Activity ◽  
Oxygen Species ◽  
Field Isolates

SUMMARYThe current trend of antimony (Sb) unresponsiveness in the Indian subcontinent is a major impediment to effective chemotherapy of visceral leishmaniasis (VL). Although contributory mechanisms studied in laboratory-raised Sb-R parasites include an up-regulation of drug efflux pumps and increased thiols, their role in clinical isolates is not yet substantiated. Accordingly, our objectives were to study the contributory role of thiols in the generation of Sb unresponsiveness in clinical isolates. Promastigotes were isolated from VL patients who were either Sb responsive (n=2) or unresponsive (n=3). Levels of thiols as measured by HPLC and flow cytometry showed higher basal levels of thiols and a faster rate of thiol regeneration in Sb unresponsive strains as compared with sensitive strains. The effects of antimony on generation of reactive oxygen species (ROS) in normal and thiol-depleted conditions as also their H2O2 scavenging activity indicated that in unresponsive parasites, Sb-mediated ROS generation was curtailed, which could be reversed by depletion of thiols and was accompanied by a higher H2O2 scavenging activity. Higher levels of thiols in Sb-unresponsive field isolates from patients with VL protect parasites from Sb-mediated oxidative stress, thereby contributing to the antimony resistance phenotype.

Uniform zinc thioporphyrazine nanosphere by self-assembly and the photocatalytic performance

2018 ◽  
Vol 22 (09n10) ◽  
pp. 868-876 ◽  
Author(s):  
Changjun Yang ◽  
Lanchang Gao ◽  
Bingguang Zhang ◽  
Zehui Zhang ◽  
Kejian Deng
Keyword(s):  
Reactive Oxygen Species ◽  
Self Assembly ◽  
Photocatalytic Performance ◽  
Aqueous Media ◽  
Reactive Oxygen ◽  
Polymerization Reaction ◽  
Oxygen Species ◽  
Paramagnetic Resonance ◽  
Novel Strategy ◽  
Means Of Transmission

A novel strategy for the synthesis of zinc thioporphyrazine nanospheres is presented. The uniform spheres were fabricated through a polymerization reaction without using any template or emulsifier, which result from the covalent links between zinc tetra(2,3-bis(pentenylthio)porphyrazine (ZnPz) possessing eight long flexible chains in periphery and each with one terminal olefin group. A possible mechanism to explain the self-assembly of ZnPz nanospheres was also illuminated through monitoring nanosphere formation by means of transmission electron microscopy (TEM). More importantly, ZnPz nanospheres can effectively activate dioxygen in aqueous media under simulated sunlight irradiation, and showed significantly improved photocatalytic activity for the degradation of Rhodamine B (RhB) as compared to monomeric ZnPz. Furthermore, the reactive oxygen species derived from ZnPz nanospheres under light irradiation were determined by electron paramagnetic resonance (EPR) technology, indicating that singlet oxygen ([Formula: see text]O[Formula: see text] and hydroxyl radical (•OH) are the major reactive oxygen species. The facile synthetic methodology and the enhanced photocatalytic performance of the ZnPz nanospheres endow this novel material with the potential of being an efficient biomimetic photocatalyst for wastewater treatment.

scholarly journals Reactive Oxygen Species Scavenging Activity of Flavone Glycosides from Melilotus neapolitana

Molecules ◽  
2007 ◽  
Vol 12 (2) ◽  
pp. 263-270 ◽  
Author(s):  
Antonio Fiorentino ◽  
Brigida D'Abrosca ◽  
Severina Pacifico ◽  
Annunziata Golino ◽  
Claudio Mastellone ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Reactive Oxygen ◽  
Scavenging Activity ◽  
Oxygen Species ◽  
Flavone Glycosides

REACTIVE OXYGEN SPECIES SCAVENGING ACTIVITY AND DNA PROTECTING EFFECT OF FRESH AND NATURALLY FERMENTED COCONUT SAP

2011 ◽  
Vol 35 (5) ◽  
pp. 1381-1388 ◽  
Author(s):  
WEIJUN CHEN ◽  
QING ZHU ◽  
QIUYU XIA ◽  
WEI CAO ◽  
SONGLIN ZHAO ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Reactive Oxygen ◽  
Scavenging Activity ◽  
Oxygen Species

scholarly journals Reactive Oxygen Species Scavenging Activity of Jixueteng Evaluated by Electron Spin Resonance (ESR) and Photon Emission

2014 ◽  
Vol 9 (12) ◽  
pp. 1934578X1400901 ◽  
Author(s):  
Toshizo Toyama ◽  
Satoko Wada-Takahashi ◽  
Maomi Takamichi ◽  
Kiyoko Watanabe ◽  
Ayaka Yoshida ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Electron Spin Resonance ◽  
Photon Emission ◽  
Herbal Medicines ◽  
Reactive Oxygen ◽  
Scavenging Activity ◽  
Oxygen Species ◽  
Ros Scavenging ◽  
Spin Resonance ◽  
Luminescence Measurement

Jixueteng, the dried stem of Spatholobus suberectus Dunn (Leguminosae), is a traditional Chinese herbal medicine that is commonly classified as a herb that promotes blood circulation and can be used to treat blood stasis. The aim of this study was to examine the reactive oxygen species (ROS) scavenging activity of Jixueteng and other herbal medicines. The ROS scavenging activities of the water extracts of Jixueteng, Cnidium officinale and Salvia miltiorrhiza were examined using an electron spin resonance (ESR) technique and faint luminescence measurement. The ESR signal intensities of the superoxide anion (O2•-) and hydroxyl radical (HO•) were reduced more by Jixueteng than the other herbal medicines we tested. High photon emission intensity to hydrogen peroxide (H2O2) and HO• was observed in Jixueteng using the XYZ chemiluminescence system that was used as faint luminescence measurement and analysis. The results of the present study revealed that the ROS scavenging activity of 8% Jixueteng was the strongest among the herbal medicines we tested. It has been reported that Jixueteng includes various polyphenols. In the ROS scavenging activity by Jixueteng, it is supposed that the antioxidant activity caused by these polyphenols would contribute greatly. In conclusion, a water extract component of Jixueteng had potent free radical scavenging activity and an antioxidative effect that inhibited the oxidative actions of O2•-, H2O2 and HO•. Therefore, Jixueteng represents a promising therapeutic drug for reactive oxygen-associated pathologies.

In vitro scavenging activity for reactive oxygen species by N-substituted indole-2-carboxylic acid esters

Luminescence ◽  
2007 ◽  
Vol 22 (4) ◽  
pp. 379-386 ◽  
Author(s):  
Irena Kruk ◽  
Hassan Y. Aboul-Enein ◽  
Teresa Michalska ◽  
Krzysztof Lichszteld ◽  
Katarzyna Kubasik-Kladna ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Carboxylic Acid ◽  
Reactive Oxygen ◽  
Scavenging Activity ◽  
Oxygen Species ◽  
Acid Esters

Radical-scavenging activity of glutathione, chitin derivatives and their combination‡

2016 ◽  
Vol 70 (6) ◽  
Author(s):  
Katarína Valachová ◽  
Tamer Mahmoud Tamer ◽  
Mohamed Mohy Eldin ◽  
Ladislav Šoltés
Keyword(s):  
Reactive Oxygen Species ◽  
Acetic Acid ◽  
Radical Scavenging Activity ◽  
Radical Scavenging ◽  
Reactive Oxygen ◽  
Scavenging Activity ◽  
Oxygen Species ◽  
Amino Derivatives ◽  
Chitin Derivatives

AbstractSince chitosan and its amino-, cinnamo- or cinnamo-amino- derivatives are acid-soluble, the effect of acetic acid on hyaluronan (HA) macromolecules degraded by Cu(II) ions and ascorbate was examined to produce reactive oxygen species (ROS). Further, the effects of glutathione (GSH), chitosan and its derivatives, added individually or in combination, on the quenching of ROS and ABTS

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