Fluorescent non-porous silica nanoparticles for long-term cell monitoring: Cytotoxicity and particle functionality

2013 ◽  
Vol 9 (11) ◽  
pp. 9183-9193 ◽  
Author(s):  
Stefaan J. Soenen ◽  
Bella Manshian ◽  
Shareen H. Doak ◽  
Stefaan C. De Smedt ◽  
Kevin Braeckmans
Keyword(s):  
Silica Nanoparticles ◽  
Porous Silica ◽  
Cell Monitoring

Polymer-Grafted Porous Silica Nanoparticles with Enhanced CO2 Permeability and Mechanical Performance

2021 ◽  
Author(s):  
Zongyu Wang ◽  
Hao Chen ◽  
Yangyang Wang ◽  
Jihua Chen ◽  
Mark A. Arnould ◽  
...  
Keyword(s):  
Silica Nanoparticles ◽  
Mechanical Performance ◽  
Porous Silica

Preparation and tableting of long-term stable amorphous rutin using porous silica

2017 ◽  
Vol 113 ◽  
pp. 97-107 ◽  
Author(s):  
Qionghua Wei ◽  
Cornelia M. Keck ◽  
Rainer H. Müller
Keyword(s):  
Porous Silica

Emerging investigator series: Long-term exposure of amorphous silica nanoparticles disrupts the lysosomal and cholesterol homeostasis in macrophages

2021 ◽  
Author(s):  
Ronglin Ma ◽  
Xiaoming Cai ◽  
Ye Zhou ◽  
Xi Liu ◽  
Di Wu ◽  
...  
Keyword(s):  
Acute Toxicity ◽  
Silica Nanoparticles ◽  
Amorphous Silica ◽  
Cholesterol Homeostasis

Amorphous silica nanoparticles (ASiNPs) are generally considered to be biocompatible with limited acute toxicity. These nanoparticles were therefore exploited in diverse nanoproducts (e.g. foods and cosmetics) and may be released...

Bone formation promoted by bone morphogenetic protein-2 plasmid-loaded porous silica nanoparticles with the involvement of autophagy

Nanoscale ◽  
2019 ◽  
Vol 11 (45) ◽  
pp. 21953-21963 ◽  
Author(s):  
Xiaowei Xu ◽  
Maolei Sun ◽  
Dandan Wang ◽  
Wenhuan Bu ◽  
Zilin Wang ◽  
...  
Keyword(s):  
Bone Formation ◽  
Osteogenic Differentiation ◽  
Silica Nanoparticles ◽  
Bone Morphogenetic Protein ◽  
Porous Silica ◽  
Bone Morphogenetic Protein 2 ◽  
Calcium Deposition ◽  
Morphogenetic Protein

Bone morphogenetic protein-2 plasmid was encapsulated by polyethylenimine-modified porous silica nanoparticles, which promoted osteogenic differentiation and increased calcium deposition with the involvement of autophagy.

Facile One-Step Dialysis Strategy for Preparation of Porous Silica Nanoparticles with Rough Surface

NANO ◽  
2020 ◽  
Vol 15 (03) ◽  
pp. 2050038
Author(s):  
Zhe Chen ◽  
Jiaqiong Xu ◽  
Xuechen Xiang ◽  
Dongfang Ren ◽  
Ning Chen ◽  
...  
Keyword(s):  
Silica Nanoparticles ◽  
Rough Surface ◽  
Mesoporous Silica Nanoparticles ◽  
Porous Silica ◽  
Catalytic Performance ◽  
Ammonia Solution ◽  
Type Iv ◽  
Organic Surfactant ◽  
One Step ◽  
Adsorption Desorption

In this study, porous silica nanoparticles were fabricated in the absence of organic surfactant template at room temperature by a facile one-step dialysis method. By using a dialysis system comprising an ammonia solution as the dialysate, a series of porous silica nanoparticles with a rough surface (e.g., raspberry-like) were obtained by the initiation of a homogeneous ternary tetraethylsilicate-water-ethanol system with different ammonia solution concentrations. The specific surface area and pore volume of porous nanoparticles were regulated by changing the dialysate concentrations. N2 adsorption–desorption measurements revealed that the porous silica nanoparticles owned both mesopores and micropores and exhibited a type IV isotherm, hence, these nanoparticles can be used as mesoporous silica nanoparticles (MSNs). The Au@MSN nanocomposite can be used as a catalyst for the typical reduction of 4-nitrophenol to 4-aminophenol by NaBH4 and exhibited excellent catalytic performance.

scholarly journals Silica nanoparticles induce unfolded protein reaction mediated apoptosis in spermatocyte cells

2020 ◽  
Vol 9 (4) ◽  
pp. 454-460
Author(s):  
Lihua Ren ◽  
Jianhui Liu ◽  
Jialiu Wei ◽  
Yefan Du ◽  
Kaiyue Zou ◽  
...  
Keyword(s):  
Silica Nanoparticles ◽  
Low Dose ◽  
Caspase 3 ◽  
Reproductive Toxicity ◽  
Chronic Effect ◽  
Unfolded Protein ◽  
Induced Apoptosis ◽  
Protein Response ◽  
Protein Reaction

Abstract With increasing air pollution, silica nanoparticles (SiNPs), as a main inorganic member of PM2.5, have gained increasing attention to its reproductive toxicity. Most existing studies focused on the acute exposure, while data regarding the chronic effect of SiNPs on reproduction is limited. Therefore, this study was designed to evaluate the chronic toxicity of SiNPs on spermatocyte cells. The cells were continuously exposed to SiNPs for 1, 10, 20 and 30 generations at dose of 5 μg/ml SiNPs for 24 h per generation after attachment. The results showed that with the increasing generations of the exposure, SiNPs decreased the viability of spermatocyte cells, induced apoptosis and increased the level of reactive oxygen species in spermatocyte cells. Moreover, SiNPs increased the protein expression of GRP-78, p-PERK, IRE1α, ATF6 and Cleaved caspase-3 in spermatocyte cells, suggesting that SiNPs improved unfolded protein response (UPR) and apoptosis. The present results indicated that the long-term and low-dose exposure to SiNPs could induce apoptosis by triggering ROS-mediated UPR in spermatocyte cells.

Long-term fate of silica nanoparticles interacting with human dermal fibroblasts

Biomaterials ◽  
2012 ◽  
Vol 33 (17) ◽  
pp. 4431-4442 ◽  
Author(s):  
Sandrine Quignard ◽  
Gervaise Mosser ◽  
Michel Boissière ◽  
Thibaud Coradin
Keyword(s):  
Silica Nanoparticles ◽  
Dermal Fibroblasts ◽  
Human Dermal Fibroblasts

Facile One-Pot Fabrication of Hollow Porous Silica Nanoparticles

2013 ◽  
Vol 20 (3) ◽  
pp. 673-677 ◽  
Author(s):  
Haitham Mohammad Abdelaal ◽  
Mahmoud Farag Zawrah ◽  
Bernd Harbrecht
Keyword(s):  
Silica Nanoparticles ◽  
Porous Silica ◽  
One Pot
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