Drug-loaded bubbles with matched focused ultrasound excitation for concurrent blood–brain barrier opening and brain-tumor drug delivery

2015 ◽  
Vol 15 ◽  
pp. 89-101 ◽  
Author(s):  
Ching-Hsiang Fan ◽  
Chien-Yu Ting ◽  
Yuan-Chih Chang ◽  
Kuo-Chen Wei ◽  
Hao-Li Liu ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Brain Tumor ◽  
Blood Brain Barrier ◽  
Focused Ultrasound ◽  
Brain Barrier ◽  
Blood Brain ◽  
Tumor Drug Delivery ◽  
Barrier Opening ◽  
Blood Brain Barrier Opening

scholarly journals Focused ultrasound blood brain barrier opening mediated delivery of MRI-visible albumin nanoclusters to the rat brain for localized drug delivery with temporal control

2019 ◽  
Author(s):  
Megan C. Rich ◽  
Jennifer Sherwood ◽  
Aundrea F. Bartley ◽  
Quentin A. Whitsitt ◽  
W.R. Willoughby ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Rat Brain ◽  
Blood Brain Barrier ◽  
Focused Ultrasound ◽  
Brain Barrier ◽  
Temporal Specificity ◽  
Blood Brain ◽  
Barrier Opening ◽  
Blood Brain Barrier Opening

AbstractThere is an ongoing need for noninvasive tools to manipulate brain activity with molecular, spatial and temporal specificity. Here we have investigated the use of MRI-visible, albumin-based nanoclusters for noninvasive, localized and temporally specific drug delivery to the rat brain. We demonstrated that IV injected nanoclusters could be deposited into target brain regions via focused ultrasound facilitated blood brain barrier opening. We showed that nanocluster location could be confirmed in vivo with MRI. Additionally, following confirmation of nanocluster delivery, release of the nanocluster payload into brain tissue can be triggered by a second focused ultrasound treatment performed without circulating microbubbles. Release of glutamate from nanoclusters in vivo caused enhanced c-Fos expression, indicating that the loading capacity of the nanoclusters is sufficient to induce neuronal activation. This novel technique for noninvasive stereotactic drug delivery to the brain with temporal specificity could provide a new way to study brain circuits in vivo preclinically with high relevance for clinical translation.Graphical Abstract

scholarly journals Pharmacokinetic analysis and drug delivery efficiency of the focused ultrasound-induced blood-brain barrier opening in non-human primates

2017 ◽  
Vol 37 ◽  
pp. 273-281 ◽  
Author(s):  
Gesthimani Samiotaki ◽  
Maria Eleni Karakatsani ◽  
Amanda Buch ◽  
Stephanos Papadopoulos ◽  
Shih Ying Wu ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Blood Brain Barrier ◽  
Focused Ultrasound ◽  
Brain Barrier ◽  
Pharmacokinetic Analysis ◽  
Blood Brain ◽  
Barrier Opening ◽  
Delivery Efficiency ◽  
Blood Brain Barrier Opening

scholarly journals Targeted drug delivery with focused ultrasound-induced blood-brain barrier opening using acoustically-activated nanodroplets

2013 ◽  
Vol 172 (3) ◽  
pp. 795-804 ◽  
Author(s):  
Cherry C. Chen ◽  
Paul S. Sheeran ◽  
Shih-Ying Wu ◽  
Oluyemi O. Olumolade ◽  
Paul A. Dayton ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Blood Brain Barrier ◽  
Targeted Drug Delivery ◽  
Focused Ultrasound ◽  
Brain Barrier ◽  
Blood Brain ◽  
Targeted Drug ◽  
Barrier Opening ◽  
Blood Brain Barrier Opening

scholarly journals Glutamate-Mediated Blood-Brain Barrier Opening: Implications for Neuroprotection and Drug Delivery

2016 ◽  
Vol 36 (29) ◽  
pp. 7727-7739 ◽  
Author(s):  
U. Vazana ◽  
R. Veksler ◽  
G. S. Pell ◽  
O. Prager ◽  
M. Fassler ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Blood Brain Barrier ◽  
Brain Barrier ◽  
Blood Brain ◽  
Barrier Opening ◽  
Blood Brain Barrier Opening
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