451: Perinatal risk factors for long-term respiratory morbidity among neonates with preterm birth and/or growth retardation

2011 ◽  
Vol 204 (1) ◽  
pp. S181-S182
Author(s):  
Margreet Teune ◽  
Aleid van Wassenaer ◽  
Ben Willem Mol ◽  
Brent Opmeer
Keyword(s):  
Risk Factors ◽  
Preterm Birth ◽  
Growth Retardation ◽  
Respiratory Morbidity ◽  
Perinatal Risk Factors ◽  
Perinatal Risk

Preterm Birth and Disruptive Cerebellar Development: Assessment of Perinatal Risk Factors

2006 ◽  
Vol 210 (S 5) ◽  
Author(s):  
A Messerschmidt ◽  
D Prayer ◽  
PC Brugger ◽  
G Zoder ◽  
W Sterniste ◽  
...  
Keyword(s):  
Risk Factors ◽  
Preterm Birth ◽  
Cerebellar Development ◽  
Perinatal Risk Factors ◽  
Perinatal Risk ◽  
Development Assessment

1-09-08 The results of long term follow up of children with perinatal risk factors

1997 ◽  
Vol 150 ◽  
pp. S16-S17
Author(s):  
S. Pitlović ◽  
R. Coha ◽  
D. Fajdetić ◽  
T. Prvulović
Keyword(s):  
Risk Factors ◽  
Perinatal Risk Factors ◽  
Perinatal Risk ◽  
Long Term Follow Up

Moderate Neonatal Encephalopathy: Prenatal and Perinatal Risk Factors and Long-Term Outcome

2008 ◽  
Vol 28 (4) ◽  
pp. 215-216
Author(s):  
K. Lindström ◽  
B. Hallberg ◽  
M. Blennow ◽  
K. Wolff ◽  
E. Fernell ◽  
...  
Keyword(s):  
Risk Factors ◽  
Neonatal Encephalopathy ◽  
Term Outcome ◽  
Long Term Outcome ◽  
Perinatal Risk Factors ◽  
Perinatal Risk

Preterm Birth and Disruptive Cerebellar Development: Assessment of Perinatal Risk Factors

2006 ◽  
Vol 210 (S 5) ◽  
Author(s):  
A Messerschmidt ◽  
D Prayer ◽  
PC Brugger ◽  
G Zoder ◽  
W Sterniste ◽  
...  
Keyword(s):  
Risk Factors ◽  
Preterm Birth ◽  
Cerebellar Development ◽  
Perinatal Risk Factors ◽  
Perinatal Risk ◽  
Development Assessment

scholarly journals Long-term development of white matter fibre density and morphology up to 13 years after preterm birth

2020 ◽  
Author(s):  
Claire E Kelly ◽  
Deanne K Thompson ◽  
Sila Genc ◽  
Jian Chen ◽  
Joseph YM Yang ◽  
...  
Keyword(s):  
Risk Factors ◽  
White Matter ◽  
Corpus Callosum ◽  
Childhood And Adolescence ◽  
Fibre Tract ◽  
Perinatal Risk Factors ◽  
Perinatal Risk ◽  
Fibre Density ◽  
Individual Fibre

AbstractBackgroundIt is well documented that infants born very preterm (VP) are at risk of brain injury and altered brain development in the neonatal period, however there is a lack of long-term, longitudinal studies on the effects of VP birth on white matter development over childhood. Most previous studies were based on voxel-averaged, non-fibre-specific diffusion magnetic resonance imaging (MRI) measures, such as fractional anisotropy. In contrast, the novel diffusion MRI analysis framework, fixel-based analysis (FBA), enables whole-brain analysis of microstructural and macrostructural properties of individual fibre populations at a sub-voxel level. We applied FBA to investigate the long-term implications of VP birth and associated perinatal risk factors on fibre development in childhood and adolescence.MethodsDiffusion images were acquired for a cohort of VP (born <30 weeks’ gestation) and full-term (FT, ≥37 weeks’ gestation) children at two ages: mean (SD) 7.6 (0.2) years (n=138 VP and 32 FT children) and 13.3 (0.4) years (n=130 VP and 45 FT children). 103 VP and 21 FT children had images at both ages for longitudinal analysis. At every fixel (individual fibre population within an image voxel) across the white matter, we compared FBA metrics (fibre density (FD), cross-section (FC) and a combination of these properties (FDC)) between VP and FT groups cross-sectionally at each age, and longitudinally between ages. We also examined associations between perinatal risk factors and FBA metrics in the VP group.ResultsCompared with FT children, VP children had lower FD, FC and FDC throughout the white matter, particularly in the corpus callosum, tapetum, inferior fronto-occipital fasciculus, fornix and cingulum at ages 7 and 13 years, as well as the motor pathways at age 13 years. VP children also had slower FDC development in the corpus callosum and corticospinal tract between ages 7 and 13 years compared with FT children. Within VP children, earlier gestational age at birth, lower birth weight z-score, and neonatal brain abnormalities were associated with lower FD, FC and FDC throughout the white matter at both ages.ConclusionsVP birth and concomitant perinatal risk factors are associated with fibre tract-specific alterations to axonal development in childhood and adolescence.

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