Relation of diurnal blood pressure variation and triglyceride-to-high-density lipoprotein cholesterol ratio in patients without diabetes mellitus

2005 ◽  
Vol 95 (1) ◽  
pp. 123-126 ◽  
Author(s):  
Michael B. Davidson ◽  
Donald G. Vidt ◽  
Byron J. Hoogwerf ◽  
Daniel J. Brotman
Keyword(s):  
Diabetes Mellitus ◽  
Blood Pressure ◽  
High Density Lipoprotein ◽  
High Density Lipoprotein Cholesterol ◽  
Density Lipoprotein ◽  
Pressure Variation ◽  
High Density ◽  
Lipoprotein Cholesterol ◽  
Cholesterol Ratio ◽  
Blood Pressure Variation

scholarly journals The relationship between monocyte to high-density lipoprotein cholesterol ratio and diabetic nephropathy

2019 ◽  
Vol 35 (4) ◽  
Author(s):  
Erhan Onalan
Keyword(s):  
Diabetes Mellitus ◽  
Diabetic Nephropathy ◽  
High Density Lipoprotein ◽  
High Density Lipoprotein Cholesterol ◽  
Statistical Significance ◽  
Density Lipoprotein ◽  
High Density ◽  
Lipoprotein Cholesterol ◽  
Cholesterol Ratio ◽  
The Relationship

Objective: This study aims to investigate the relationship of monocyte to high-density lipoprotein cholesterol ratio (MHR) with diabetes mellitus (DM) and diabetic nephropathy. Methods: This study included 262 Type-2 diabetes mellitus patients, of which 60 had diabetic nephropathy and 202 did not have diabetic nephropathy who presented to the internal diseases polyclinic at Firat University Medical Faculty Hospital between May 2018 and October 2018 and 50 healthy control subjects. A retrospective scan of patient files was conducted and information relevant to nephropathy such as hemoglobin, glycated hemoglobin levels (HbA1c), hematocrit count (HCT), monocyte count, LDL, HDL, triglyceride levels, and microvascular complications were acquired. Results: We determined MHR values as 11.9±5.5 and 8.4±2.9 respectively for the diabetic and healthy groups. There was a statistically significant difference between the two groups in terms of MHR, with a positive correlation between diabetes and MHR (< 0.001; r: 0.241). Moreover, glucose, HDL, and triglyceride levels were different between the two groups with statistical significance (respectively, p< 0.001; p< 0.001; p< 0.001). Our study found higher MHR levels for patients with diabetic nephropathy compared to those without diabetic nephropathy (respectively, 17.1±7.9 and 10.3±3.3) and determined statistical significance and a negative correlation (p< 0.001; r: -0.512). Conclusion: Our results suggest that an elevated MHR can be a biomarker for diabetic nephropathy, allowing the detection of diabetic nephropathy with simple and inexpensive laboratory tests. doi: https://doi.org/10.12669/pjms.35.4.534 How to cite this:Onalan E. The relationship between monocyte to high-density lipoprotein cholesterol ratio and diabetic nephropathy. Pak J Med Sci. 2019;35(4):---------. doi: https://doi.org/10.12669/pjms.35.4.534 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

COMPARITIVE STUDY OF HDL-C LEVEL IN DIABETIC AND NONDIABETIC STROKE SUBJECTS

1969 ◽  
Vol 6 (2) ◽  
pp. 816-820
Author(s):  
SAHIBZADA SAEED JAN ◽  
AMIN JAN ◽  
JAN.I.ALAM ◽  
TAJ MUHAMMAD KHAN
Keyword(s):  
Diabetes Mellitus ◽  
Blood Pressure ◽  
High Density Lipoprotein ◽  
High Density Lipoprotein Cholesterol ◽  
Density Lipoprotein ◽  
High Density ◽  
Lipoprotein Cholesterol ◽  
Diabetic Patients ◽  
Stroke Patients ◽  
History Of

BACKGROUND: Diabetes mellitus is a well recognized risk factor for acute stroke, resulting in agreater ischemic to hemorrhagic stroke ratio in the people with diabetes compared with the generalpopulation. Diabetes also doubles the risk of stroke recurrence and has a poor outcome (or having poorprognosis for survival) as compared to non-diabetic patients, warranting strong and comprehensivepreventive efforts, The aim of this study was to evaluate the High Density Lipoprotein-Cholesterol(HDL-C) level in the adult diabetic and non-diabetic stroke patients coming to Medical Unit of SaiduTeaching Hospital, Swat.MATERIAL AND METHODOLOGY: This was a cross-sectional study, comprised of 100 subjects,50 were diabetic and 50 were non -diabetic stroke patients of ages between 40 to 90 years. The studysubjects underwent a detailed history and examination. Individuals with a history of medications knownto affects body composition, patients on anti-coagulants and having a history of blood dyscrasias likeleukemia’s, thalasemia, polycythemia, endocrinopathies and patients having clotting disorders, extraduraland intradural hemorrhage as a cause of stroke were excluded from the study. Fasting as well as randomblood sample were drawn from the participants for biochemical assays. The serum HDL-C level, bloodsugar (random and fasting), blood pressure (systolic and diastolic) of Diabetic stroke subjects werecompared with Non-diabetic stroke subjects.RESULTS: The HDL-C level was significantly low in our study in diabetic as compared to nondiabetic stroke subjects.CONCLUSION: The low HDL-C level along with poor metabolic control is an important risk factorfor chronic complications of diabetes mellitus like microvascular and macrovascular disease likeunstable angina, myocardial infarction and stroke. Therefore there is intense need of early screening andinterventions, to prevent macrovascular complications especially stroke in high risk diabetic patients.KEY WORDS: Diabetes mellitus, High-density Lipoprotein-Cholesterol (HDL-C), Blood pressure,Stroke.

scholarly journals Evaluation of non-HDL-c and total cholesterol: HDL-c Ratio as Cumulative Marker of Cardiovascular Risk in Diabetes Mellitus

2012 ◽  
Vol 8 (4) ◽  
pp. 398-404
Author(s):  
M Aryal ◽  
A Poudel ◽  
B Satyal ◽  
P Gyawali ◽  
B R Pokheral ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Blood Pressure ◽  
Cardiovascular Risk ◽  
High Density Lipoprotein ◽  
Total Cholesterol ◽  
High Density Lipoprotein Cholesterol ◽  
Density Lipoprotein ◽  
High Density ◽  
Lipoprotein Cholesterol ◽  
Cvd Risk

Background Cardiovascular disease (CVD), is the primary cause of morbidity and mortality in patients with diabetes and have approximately - two to four times higher CVD rate than adult without diabetes. Low density lipoprotein cholesterol (LDL-C) is primarily used as the marker of cardiovascular risk in diabetes despite its several limitations. Although several newer markers of CVD are emerging, no marker has been established in Nepal. Objectives The study was designed to evaluate the non-high-density-lipoprotein- cholesterol(Non-HDL-C) and Total Cholesterol to High density lipoprotein cholesterol (TC:HDL-C ratio) as CVD risk marker in diabetes mellitus. Methods The study was conducted in the Department of Bbiochemistry, Kathmandu University School of Medical Sciences. The study comprised of 76 diabetic subjects and 60 non-diabetic subjects. The anthropometric and biochemical parameters were measured. The Non-HDL-C and TC:HDL-C ratio were also calculated employing their respective formula. Results Body mass index (BMI), waist circumference (WC), blood pressure and lipid parameters were significantly different between diabetic subjects and non-diabetic subjects. There was increased non-HDL-C and TC:HDL-C ratio in subjects with diabetes mellitus. Furthermore, statistically significant correlations of non-HDL-C and TC:HDL-C ratio were obtained with BMI, WC, total cholesterol, HDL-C and LDL-C in diabetic subjects. Conclusions The present study observation revealed that the Non-HDL-C and TC: HDL-C strongly correlate with established independent risk factors such as obesity(WC), elevated blood pressure, HDL-C and LDL-C in diabetes. Thus, the evaluation of Non-HDL-C and TC: HDL-C ratio can be used as the simple, cost-effective and cumulative marker of cardiovascular risk in diabetes mellitus.http://dx.doi.org/10.3126/kumj.v8i4.6239 Kathmandu Univ Med J 2010;8(4):398-404 

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