scholarly journals Worsening severity of vitamin D deficiency is associated with increased length of stay, surgical intensive care unit cost, and mortality rate in surgical intensive care unit patients

2012 ◽  
Vol 204 (1) ◽  
pp. 37-43 ◽  
Author(s):  
L. Ray Matthews ◽  
Yusuf Ahmed ◽  
Kenneth L. Wilson ◽  
Diane D. Griggs ◽  
Omar K. Danner
2012 ◽  
Vol 40 (4) ◽  
pp. 1122-1128 ◽  
Author(s):  
George Kasotakis ◽  
Ulrich Schmidt ◽  
Dana Perry ◽  
Martina Grosse-Sundrup ◽  
John Benjamin ◽  
...  

2022 ◽  
Vol 22 (1) ◽  
Author(s):  
Keke Song ◽  
Tingting Yang ◽  
Wei Gao

Abstract Background Serum chloride (Cl−) is one of the most essential extracellular anions. Based on emerging evidence obtained from patients with kidney or heart disease, hypochloremia has been recognized as an independent predictor of mortality. Nevertheless, excessive Cl− can also cause death in severely ill patients. This study aimed to investigate the relationship between hyperchloremia and high mortality rate in patients admitted to the surgical intensive care unit (SICU). Methods We enrolled 2131 patients from the Multiparameter Intelligent Monitoring in Intensive Care III database version 1.4 (MIMIC-III v1.4) from 2001 to 2012. Selected SICU patients were more than 18 years old and survived more than 72 h. A serum Cl− level ≥ 108 mEq/L was defined as hyperchloremia. Clinical and laboratory variables were compared between hyperchloremia (n = 664) at 72 h post-ICU admission and no hyperchloremia (n = 1467). The Locally Weighted Scatterplot Smoothing (Lowess) approach was utilized to investigate the correlation between serum Cl- and the thirty-day mortality rate. The Cox proportional-hazards model was employed to investigate whether serum chlorine at 72 h post-ICU admission was independently related to in-hospital, thirty-day and ninety-day mortality from all causes. Kaplan-Meier curve of thirty-day and ninety-day mortality and serum Cl− at 72 h post-ICU admission was further constructed. Furthermore, we performed subgroup analyses to investigate the relationship between serum Cl− at 72 h post-ICU admission and the thirty-day mortality from all causes. Results A J-shaped correlation was observed, indicating that hyperchloremia was linked to an elevated risk of thirty-day mortality from all causes. In the multivariate analyses, it was established that hyperchloremia remained a valuable predictor of in-hospital, thirty-day and ninety-day mortality from all causes; with adjusted hazard ratios (95% CIs) for hyperchloremia of 1.35 (1.02 ~ 1.77), 1.67 (1.28 ~ 2.19), and 1.39 (1.12 ~ 1.73), respectively. In subgroup analysis, we observed hyperchloremia had a significant interaction with AKI (P for interaction: 0.017), but there were no interactions with coronary heart disease, hypertension, and diabetes mellitus (P for interaction: 0.418, 0.157, 0.103, respectively). Conclusion Hyperchloremia at 72 h post-ICU admission and increasing serum Cl− were associated with elevated mortality risk from all causes in severely ill SICU patients.


2011 ◽  
Vol 17 (8) ◽  
pp. S72 ◽  
Author(s):  
Alpesh Amin ◽  
Steven Deitelzweig ◽  
Jay Lin ◽  
Kathy Belk ◽  
Dorothy Baumer ◽  
...  

Sign in / Sign up

Export Citation Format

Share Document